GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant

Molecular and Cellular Endocrinology - Tập 173 - Trang 193-202 - 2001
Timothy J. Cole1, Kathy Myles1, Jared F. Purton1,2, Phillip S. Brereton1, Nicola M. Solomon1, Dale I. Godfrey2, John W. Funder1
1Baker Medical Research Institute, Commercial Road, Prahran, Victoria, 3181, Australia
2Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria 3181, Australia

Tài liệu tham khảo

Ausebel, 1993, 1 Ballard, 1979 Beato, 1995, Steroid hormone receptors: many actors in search of a plot, Cell, 83, 851, 10.1016/0092-8674(95)90201-5 Berger, 1998, Mineralocorticoid receptor knockout mice: Pathophysiology of Na+ metabolism, Proc. Natl Acad. Sci. USA, 95, 9424, 10.1073/pnas.95.16.9424 Blendy, 1996, Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform, EMBO J., 15, 1098, 10.1002/j.1460-2075.1996.tb00447.x Christoffels, 1998, The glucocorticoid receptor, C/EBP, HNF3 and protein kinase A, coordinately activate the glucocorticoid-response unit of the carbamoylphosphate synthetase-I gene, Molec. Cell Biol., 18, 6305, 10.1128/MCB.18.11.6305 Cole, 1996, Steroid receptor knockouts, Curr. Opin. Endocr. Diabetes, 3, 363, 10.1097/00060793-199610000-00002 Cole, 1995, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation, Genes Development, 9, 1608, 10.1101/gad.9.13.1608 Cole, 1999, The glucocorticoid receptor is essential for maintaining both basal expression and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene, Molec. Cell Endocr., 154, 29, 10.1016/S0303-7207(99)00105-7 Couse, 1995, Analysis of transcription and estrogen insensitivity in the female mouse and targeted disruption of the estrogen receptor gene, Molec. Endocr., 9, 1441, 10.1210/me.9.11.1441 Edwards, 1988, Localization of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor, Lancet, 2, 986, 10.1016/S0140-6736(88)90742-8 Finotto, 1999, Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells, Development, 126, 2935, 10.1242/dev.126.13.2935 Funder, 1997, Glucocorticoid and mineralocorticoid receptors:biology and clinical relevance, Annu. Rev. Med., 48, 231, 10.1146/annurev.med.48.1.231 Funder, 1988, Mineralocorticoid action: target–tissue specificity is enzyme, not receptor mediated, Science, 242, 583, 10.1126/science.2845584 Gaspar, 1991, A single base deletion in the Tfm androgen receptor gene creates a shot-lived messenger RNA that directs internal translation initiation, Proc. Natl Acad. Sci. USA, 88, 8606, 10.1073/pnas.88.19.8606 Hammond, 1993, Extracellular steroid-binding proteins, 1 Hesen, 1996, Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption, J. Neuroscience, 16, 6766, 10.1523/JNEUROSCI.16-21-06766.1996 Karl, 1993, Familial glucocorticoid resistance: an overview, Exp. Clin. Endocr., 101, 30, 10.1055/s-0029-1211204 Kozak, 1986, Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes, Cell, 44, 283, 10.1016/0092-8674(86)90762-2 Kretz, 1999, Corticotropin-releasing hormone expression is the major target for glucocorticoid feedback-control at the hypothalamic level, Brain Res., 818, 488, 10.1016/S0006-8993(98)01277-3 Lathe, 1996, Mice, gene targeting and behavior, more than just genetic background, Trends Neurosci., 19, 183, 10.1016/S0166-2236(96)20022-0 Lubahn, 1993, Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene, Proc. Natl Acad. Sci. USA, 90, 11162, 10.1073/pnas.90.23.11162 Mangelsdorf, 1995, The nuclear receptor superfamily: a second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X Oitzl, 1997, Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption, Eur. J. Neurosci., 9, 2284, 10.1111/j.1460-9568.1997.tb01646.x Olsen, 1996, Know thy neighbors: Three phenotypes in null mutants of the myogenic bHLH gne MRF4, Cell, 85, 1, 10.1016/S0092-8674(00)81073-9 Orth, 1992, The Adrenal Cortex, 489 Parker, 1993, Steroid and related receptors, Current Opinion in Cell Biology, 5, 499, 10.1016/0955-0674(93)90016-J Pech, 1997, 5′ sequences direct developmental expression and hormone responsiveness of tyrosine aminotransferase in primary cultures of fetal rat hepatocytes, Eur. J. Biochem., 249, 675, 10.1111/j.1432-1033.1997.t01-1-00675.x Reichhardt, 1996, Feedback control of glucocorticoid production is established during fetal development, Molec. Med., 2, 735, 10.1007/BF03401657 Reichhardt, 1998, DNA binding of the glucocorticoid receptor is not essential for survival, Cell, 93, 531, 10.1016/S0092-8674(00)81183-6 Rozmahel, 1996, Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor, Nature Genetics, 12, 280, 10.1038/ng0396-280 Strahle, 1992, At least three promoters direct expression of the mouse glucocorticoid receptor gene, Proc. Natl Acad. Sci. USA, 89, 6731, 10.1073/pnas.89.15.6731 Thompson, 1994, Apoptosis and steroid hormones, Molec. Endocr., 8, 665, 10.1210/me.8.6.665 Threadgill, 1995, Targeted disruption of the mouse EGF receptor: effect of genetic background on mutant phenotype, Science, 269, 230, 10.1126/science.7618084 Tronche, 1999, Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety, Nature Genetics, 23, 99, 10.1038/12703