Attenuation of bleomycin-induced lung fibrosis by oral sulfhydryl containing antioxidants in rats: erdosteine and N-acetylcysteine

Gross, 2001, Idiopathic pulmonary fibrosis, N Engl J Med, 345, 517, 10.1056/NEJMra003200 Weissler, 1989, Idiopathic pulmonary fibrosis: cellular and molecular pathogenesis, Am J Med Sci, 297, 92, 10.1097/00000441-198902000-00005 Serrano-Mollar, 2002, P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-l-cysteine, Thorax, 57, 629, 10.1136/thorax.57.7.629 Serrano-Mollar, 2003, In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats, Br J Pharmacol, 138, 1037, 10.1038/sj.bjp.0705138 Cortijo, 2001, Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats, Eur Respir J, 17, 1228, 10.1183/09031936.01.00049701 Sogut, 2004, Protection of erdosteine on bleomycine-induced lung fibrosis in rats, Eur J Pharmacol, 494, 213, 10.1016/j.ejphar.2004.04.045 Berend, 1985, Inhibition of bleomycin lung toxicity by N-acetyl cysteine in the rat, Pathology, 17, 108, 10.3109/00313028509063736 Behr, 1997, Antioxidant and clinical effect of high dose N-acetylcysteine in fibrosan alveolitis. Adjunctive therapy to maintenance immunosupression, Am J Respir Crit Care Med, 156, 1897, 10.1164/ajrccm.156.6.9706065 Dechant, 1996, Erdosteine, Drugs, 52, 875, 10.2165/00003495-199652060-00009 Kaise, 1993, Effects of KW-9144 on paraquat toxicity in mice and bleomycin-induced lung injury in rats (abstract), Jpn J Pharmacol, 61, 81, 10.1016/S0021-5198(19)51234-3 Yildirim, 2004, Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats, Nitric Oxide, 11, 156, 10.1016/j.niox.2004.07.011 Yildirim, 2003, Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats, Pharmacol Res, 47, 149, 10.1016/S1043-6618(02)00282-7 Fadillioglu, 2003, Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats, J Appl Toxicol, 23, 71, 10.1002/jat.889 Oury, 2001, Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin, Am J Respir Cell Mol Biol, 25, 164, 10.1165/ajrcmb.25.2.4235 Tamagawa, 2000, Inhibitory effects of a lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis in mice, Am J Respir Crit Care Med, 161, 1279, 10.1164/ajrccm.161.4.9906099 Dohi, 2000, Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis, Am J Respir Crit Care Med, 162, 2302, 10.1164/ajrccm.162.6.9908097 Hagiwara, 2000, Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice, Am J Respir Crit Care Med, 162, 225, 10.1164/ajrccm.162.1.9903129 Ashcroft, 1988, Simple method of estimating severity of pulmonary fibrosis on a numerical scale, J Clin Pathol, 41, 467, 10.1136/jcp.41.4.467 Pagia, 1967, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, J Lab Clin Med, 70, 158 Cortas, 1990, Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method, Clin Chem, 36, 1440, 10.1093/clinchem/36.8.1440 Wasowicz, 1993, Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage, Clin Chem, 39, 2522, 10.1093/clinchem/39.12.2522 Wei, 1993, Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters, Carcinogenesis, 14, 1195, 10.1093/carcin/14.6.1195 Woessner, 1961, The determination of hidroxyproline in tissue and protein samples containing small proportions of this amino acid, Arch Biochem Biophysics, 93, 440, 10.1016/0003-9861(61)90291-0 Hay, 1991, Mechanisms of bleomycin-induced lung damage, Arch Toxicol, 65, 81, 10.1007/BF02034932 Holdiness, 1991, Clinical pharmacokinetics of N-acetylcysteine, Clin Pharmacokinet, 20, 123, 10.2165/00003088-199120020-00004 Sagrista, 2002, Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-l-cysteine and glutathione against free radical-induced lipid peroxidation, Free Radic Res, 36, 329, 10.1080/10715760290019354 Bridgeman, 1991, Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine, Thorax, 46, 39, 10.1136/thx.46.1.39 Mata, 2003, Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats, Eur Respir J, 22, 900, 10.1183/09031936.03.00018003 Giri, 2002, Abrogation of bleomycin-induced lung fibrosis by nitric oxide synthase inhibitor, aminoguanidine in mice, Nitric Oxide, 7, 109, 10.1016/S1089-8603(02)00102-7 Saleh, 1997, Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis, Am J Respir Crit Care Med, 155, 1763, 10.1164/ajrccm.155.5.9154889 Gow, 1996, Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation, FEBS Lett, 385, 63, 10.1016/0014-5793(96)00347-X