A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

Ambrosio, 1989, I(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo, Development, 106, 145, 10.1242/dev.106.1.145 Ambrosio, 1989, Requirement of the Drosophila raf homologue for torso function, Nature, 342, 288, 10.1038/342288a0 Anderson, 1991, Raf-1 is a potential substrate for mitogenactivated protein kinase in vivo, Biochem. J., 277, 573, 10.1042/bj2770573 Baccarini, 1991, Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization, J. Biol. Chem., 266, 10941, 10.1016/S0021-9258(18)99110-6 Basler, 1988, Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain, Cell, 54, 299, 10.1016/0092-8674(88)90193-6 Biggs, 1992, Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase, 89, 6295 Boguslawski, 1987, Complete nucleotide sequence of a gene conferring polymyoxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases, 84, 5848 Brown, 1988, Functional cDNA libraries from Drosophila embryos, J. Mol. Biol., 203, 425, 10.1016/0022-2836(88)90010-1 Cairns, 1992, Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of STE11 kinase and the multiple phosphorylation of the STE7 kinase, Genes Dev., 6, 1305, 10.1101/gad.6.7.1305 Crews, 1992, The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product, Science, 258, 478, 10.1126/science.1411546 Degelman, 1986, Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus, Dev. Biol., 115, 479, 10.1016/0012-1606(86)90268-X Gartner, 1992, Signal transduction in Saccharomyces cerevisiae required tyrosine and threonine phosphorylation of FUS3 and KSS1, Genes Dev., 6, 1280, 10.1101/gad.6.7.1280 Howe, 1992, Activation of the MAP kinase pathway by the protein kinase raf, Cell, 71, 335, 10.1016/0092-8674(92)90361-F Klingler, 1988, Function of torso in determining the terminal analgen of the Drosophila embryo, Nature, 335, 275, 10.1038/335275a0 Kosako, 1992, Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation, EMBO J., 11, 2903, 10.1002/j.1460-2075.1992.tb05359.x Kyriakis, 1992, Raf-1 activates MAP kinase-kinase, Nature, 358, 417, 10.1038/358417a0 Lawrence, 1986, Methods of marking cells, 229 Lee, 1992, Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases, J. Biol. Chem., 267, 1088, 10.1016/S0021-9258(18)48399-8 Li, 1991, Raf-1: a kinase currently without a cause but not lacking in effects, Cell, 64, 479, 10.1016/0092-8674(91)90228-Q Lindsley, 1992 Marsh, 1991, Signal transduction during pheromone response in yeast, Annu. Rev. Cell Biol., 7, 699, 10.1146/annurev.cb.07.110191.003411 Nadin-Davis, 1988, A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast, EMBO J., 7, 985, 10.1002/j.1460-2075.1988.tb02905.x Nishida, 1988, Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene, EMBO J., 7, 775, 10.1002/j.1460-2075.1988.tb02875.x Nüsslein-Volhard, 1987, Determination of anteroposterior polarity in Drosophila, Science, 238, 1675, 10.1126/science.3686007 Pelech, 1992, Mitogen-activated protein kinases: versatile transducers for cell signalling, Trends Biochem. Sci., 17, 233, 10.1016/S0968-0004(00)80005-5 Perkins, 1992, corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso, Cell, 70, 225, 10.1016/0092-8674(92)90098-W Perrimon, 1985, A pupal lethal mutation with paternally influenced maternal effect on embryonic development in Drosophila melanogaster, Dev. Biol., 110, 480, 10.1016/0012-1606(85)90105-8 Perrimon, 1986, X-linked female-sterile loci in Drosophila melanogaster, Genetics, 113, 695, 10.1093/genetics/113.3.695 Pignoni, 1990, The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily, Cell, 62, 151, 10.1016/0092-8674(90)90249-E Pignoni, 1992, bicoid and the terminal system activate tailless expression in the early Drosophila embryo, Development, 115, 239, 10.1242/dev.115.1.239 Poole, 1985, The engrailed locus of Drosophila: structural analysis of an embryonic transcript, Cell, 40, 37, 10.1016/0092-8674(85)90306-X Postlethwait, 1978, Clonal analysis of Drosophila cuticular patterns, Volume 2, 359 Price, 1989, The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog, Cell, 56, 1085, 10.1016/0092-8674(89)90641-7 Rapp, 1991, Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction, Oncogene, 6, 495 Robertson, 1988, A stable genomic source of P element transposase in Drosophila melanogaster, Genetics, 118, 461, 10.1093/genetics/118.3.461 Sambrook, 1989 Schejter, 1989, The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, locus essential for embryonic development, Cell, 56, 1093, 10.1016/0092-8674(89)90642-9 Schüpbach, 1986, Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo, Roux's Arch. Dev. Biol., 195, 302, 10.1007/BF00376063 Simon, 1991, Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signalling by the sevenless protein tyrosine kinase, Cell, 67, 701, 10.1016/0092-8674(91)90065-7 Sprenger, 1989, The Drosophila gene torso encodes a putative receptor tyrosine kinase, Nature, 338, 478, 10.1038/338478a0 Stevens, 1990, Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo, Nature, 346, 660, 10.1038/346660a0 Stevenson, 1992, Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein, Genes Dev., 6, 1293, 10.1101/gad.6.7.1293 Strecker, 1986, The zygotic mutant tailless affects the anterior and posterior ectodermal regions of the Drosophila embryo, Dev. Biol., 113, 64, 10.1016/0012-1606(86)90108-9 Strecker, 1989, Reciprocal effects of hyper-and hypoactivity mutations in the Drosophila pattern gene torso, Science, 243, 1062, 10.1126/science.2922596 Tautz, 1989, A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of segmentation gene hunchback, Chromosoma, 98, 81, 10.1007/BF00291041 Teague, 1986, Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases, 83, 7371 Wang, 1991, byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype, Mol. Cell. Biol., 11, 3554 Weigel, 1990, Two gap genes mediate maternal terminal pattern information in Drosophila, Science, 248, 495, 10.1126/science.2158673 Wieschaus, 1986, Looking at embryos, 199