Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Brewer, 1993, Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination, J. Neurosci. Res., 35, 567, 10.1002/jnr.490350513 Casanova, 2001, A CamKIIalpha iCre BAC allows brain-specific gene inactivation, Genesis, 31, 37, 10.1002/gene.1078 Chen, 2003, Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells, FASEB J., 17, 1694, 10.1096/fj.02-0847fje Conrad, 2003, Optimized vector for conditional gene targeting in mouse embryonic stem cells, Biotechniques, 34, 1136, 10.2144/03346bm03 Conrad, 2004, Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function, Mol. Cell. Biol., 24, 9414, 10.1128/MCB.24.21.9414-9423.2004 Conrad, 2005, The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability, Mol. Cell. Biol., 25, 7637, 10.1128/MCB.25.17.7637-7644.2005 Culmsee, 2005, Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia, J. Neurosci., 25, 10262, 10.1523/JNEUROSCI.2818-05.2005 Dymecki, 1996, Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice, Proc. Natl. Acad. Sci. USA, 93, 6191, 10.1073/pnas.93.12.6191 Flohe, 1984, Assays of glutathione peroxidase, Methods Enzymol., 105, 114, 10.1016/S0076-6879(84)05015-1 Fridlyand, 2005, Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches, Ann. N Y Acad. Sci., 1066, 136, 10.1196/annals.1363.019 Funk, 2001, 12/15-lipoxygenase, oxidative modification of LDL and atherogenesis, Trends Cardiovasc. Med., 11, 116, 10.1016/S1050-1738(01)00096-2 Harms, 2000, Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures, FASEB J., 14, 1814, 10.1096/fj.99-0899com Hockenbery, 1993, Bcl-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75, 241, 10.1016/0092-8674(93)80066-N Imai, 1998, Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase, J. Biol. Chem., 273, 1990, 10.1074/jbc.273.4.1990 Li, 1997, A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion, Neuron, 19, 453, 10.1016/S0896-6273(00)80953-8 Lin, 2006, Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases, Nature, 443, 787, 10.1038/nature05292 Madamanchi, 2007, Mitochondrial dysfunction in atherosclerosis, Circ. Res., 100, 460, 10.1161/01.RES.0000258450.44413.96 Mauri, 2003, Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MS, Biol. Chem., 384, 575, 10.1515/BC.2003.065 Modjtahedi, 2006, Apoptosis-inducing factor: vital and lethal, Trends Cell Biol., 16, 264, 10.1016/j.tcb.2006.03.008 Moreno, 2003, Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx), Biol. Chem., 384, 635, 10.1515/BC.2003.070 Roveri, 1994, Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes, Biochim. Biophys. Acta, 1208, 211, 10.1016/0167-4838(94)90106-6 Schnurr, 1996, The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products, J. Biol. Chem., 271, 4653, 10.1074/jbc.271.9.4653 Schwenk, 1995, A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells, Nucleic Acids Res., 23, 5080, 10.1093/nar/23.24.5080 Sendobry, 1997, Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties, Br. J. Pharmacol., 120, 1199, 10.1038/sj.bjp.0701007 Shi, 2000, Glutathione synthesis is essential for mouse development but not for cell growth in culture, Proc. Natl. Acad. Sci. USA, 97, 5101, 10.1073/pnas.97.10.5101 Sun, 1996, Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein, J. Biol. Chem., 271, 24055, 10.1074/jbc.271.39.24055 Susin, 1999, Molecular characterization of mitochondrial apoptosis-inducing factor, Nature, 397, 441, 10.1038/17135 Sutherland, 2001, Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism, Biochem. J., 353, 91, 10.1042/bj3530091 Thomas, 1990, Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins, Biochim. Biophys. Acta, 1045, 252, 10.1016/0005-2760(90)90128-K Ursini, 1982, Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides, Biochim. Biophys. Acta, 710, 197, 10.1016/0005-2760(82)90150-3 van Leyen, 2006, Baicalein and 12/15-lipoxygenase in the ischemic brain, Stroke, 37, 3014, 10.1161/01.STR.0000249004.25444.a5 Verrou, 1999, Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer, Biol. Chem., 380, 1435, 10.1515/BC.1999.184 Yant, 2003, The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults, Free Radic. Biol. Med., 34, 496, 10.1016/S0891-5849(02)01360-6