Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes
Tài liệu tham khảo
Abbott, 1999, The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses, Journal of Neuroscience, 19, 7300, 10.1523/JNEUROSCI.19-17-07300.1999
Aberg, 2000, Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus, Journal of Neuroscience, 20, 2896, 10.1523/JNEUROSCI.20-08-02896.2000
Aberg, 2003, IGF-I has a direct proliferative effect in adult hippocampal progenitor cells, Molecular and Cellular Neurosciences, 24, 23, 10.1016/S1044-7431(03)00082-4
Aberg, 2007, Peripheral infusion of insulin-like growth factor-I increases the number of newborn oligodendrocytes in the cerebral cortex of adult hypophysectomized rats, Endocrinology, 148, 3765, 10.1210/en.2006-1556
Ahmadian, 2004, Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD, EMBO Journal, 23, 1040, 10.1038/sj.emboj.7600126
Aimone, 2006, Potential role for adult neurogenesis in the encoding of time in new memories, Nature Neuroscience, 9, 723, 10.1038/nn1707
Akanmu, 2009, Analgesic, learning and memory and anxiolytic effects of insulin in mice, Behavioural Brain Research, 196, 237, 10.1016/j.bbr.2008.09.008
Akisaki, 2006, Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT), Diabetes–Metabolism Research and Reviews, 22, 376, 10.1002/dmrr.632
Anderson, 2002, Insulin-like growth factor-I and neurogenesis in the adult mammalian brain, Brain Research. Developmental Brain Research, 134, 115, 10.1016/S0165-3806(02)00277-8
Annenkov, 2009, The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis, Molecular Neurobiology, 40, 195, 10.1007/s12035-009-8081-0
Arsenault, 2011, DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice, PLoS ONE, 6, e17397, 10.1371/journal.pone.0017397
Arvanitakis, 2004, Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function, Archives of Neurology, 61, 661, 10.1001/archneur.61.5.661
Auestad, 2003, Visual, cognitive, and language assessments at 39 months, a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age, Pediatrics, 112, e177, 10.1542/peds.112.3.e177
Awad, 2004, The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function, Journal of Clinical and Experimental Neuropsychology, 26, 1044, 10.1080/13803390490514875
Babri, 2007, Intrahippocampal insulin improves memory in a passive-avoidance task in male Wistar rats, Brain and Cognition, 64, 86, 10.1016/j.bandc.2007.01.002
Banas, 2009, A dietary fat excess alters metabolic and neuroendocrine responses before the onset of metabolic diseases, Cellular and Molecular Neurobiology, 29, 157, 10.1007/s10571-008-9307-9
Banks, 2004, The source of cerebral insulin, European Journal of Pharmacology, 490, 5, 10.1016/j.ejphar.2004.02.040
Banks, 2006, Denial versus dualism, the blood–brain barrier as an interface of the gut–brain axis, Endocrinology, 147, 2609, 10.1210/en.2006-0335
Banks, 1997, Transport of insulin across the blood–brain barrier: Saturability at euglycemic doses of insulin, Peptides, 18, 1423, 10.1016/S0196-9781(97)00231-3
Banks, 1997, Effect of diabetes mellitus on the permeability of the blood–brain barrier to insulin, Peptides, 18, 1577, 10.1016/S0196-9781(97)00238-6
Banks, 1997, Selective, physiological transport of insulin across the blood–brain barrier: Novel demonstration by species-specific radioimmunoassays, Peptides, 18, 1257, 10.1016/S0196-9781(97)00198-8
Banks, 1998, Differential permeability of the blood–brain barrier to two pancreatic peptides: Insulin and amylin, Peptides, 19, 883, 10.1016/S0196-9781(98)00018-7
Bateman, 2006, Insulin/IGF signalling in neurogenesis, Cellular and Molecular Life Sciences, 63, 1701, 10.1007/s00018-006-6036-4
Baura, 1993, Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain, Journal of Clinical Investigation, 92, 1824, 10.1172/JCI116773
Becker, 2007, A model of hippocampal neurogenesis in memory and mood disorders, Trends in Cognitive Sciences, 11, 70, 10.1016/j.tics.2006.10.013
Belanger, 2004, Preserved LTP and water maze learning in hyperglycaemic-hyperinsulinemic ZDF rats, Physiology and Behavior, 83, 483, 10.1016/j.physbeh.2004.08.031
Benedict, 2004, Intranasal insulin improves memory in humans, Psychoneuroendocrinology, 29, 1326, 10.1016/j.psyneuen.2004.04.003
Benedict, 2007, Intranasal insulin improves memory in humans: Superiority of insulin aspart, Neuropsychopharmacology, 32, 239, 10.1038/sj.npp.1301193
Bernstein, 1999, Insulin-degrading enzyme in the AD brain: Prominent localisation in neurons and senile plaques, Neuroscience Letters, 263, 161, 10.1016/S0304-3940(99)00135-4
Biessels, 2008, Cognition and diabetes: A lifespan perspective, Lancet Neurology, 7, 184, 10.1016/S1474-4422(08)70021-8
Biessels, 1996, Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats, Diabetes, 45, 1259, 10.2337/diabetes.45.9.1259
Biessels, 1998, Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Effects of insulin treatment, Brain Research, 800, 125, 10.1016/S0006-8993(98)00510-1
Bingham, 2002, The role of insulin in human brain glucose metabolism: An 18fluoro-deoxyglucose positron emission tomography study, Diabetes, 51, 3384, 10.2337/diabetes.51.12.3384
Birch, 1984, Immunoreactive insulin from mouse brain cells in culture and whole rat brain, Biochemical Journal, 218, 19, 10.1042/bj2180019
Birch, 1984, Proinsulin-like material in mouse foetal brain cell cultures, FEBS Letters, 168, 299, 10.1016/0014-5793(84)80266-5
Brands, 2007, Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: A comparative study, Dementia and Geriatric Cognitive Disorders, 23, 343, 10.1159/000100980
Broadwell, 1983, Brain–blood barrier? Yes and no, Proceedings of the National Academy of Sciences of the United States of America, 80, 7352, 10.1073/pnas.80.23.7352
Bruehl, 2009, Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus, Brain Research, 1280, 186, 10.1016/j.brainres.2009.05.032
Brunetti, 1998, Decreased brain glucose utilization in patients with Cushing’s disease, Journal of Nuclear Medicine, 39, 786
Canal, 2005, Glucose injections into the dorsal hippocampus or dorsolateral striatum of rats prior to T-maze training: Modulation of learning rates and strategy selection, Learn Memory, 12, 367, 10.1101/lm.88205
Cao, 2004, VEGF links hippocampal activity with neurogenesis, learning and memory, Nature Genetics, 36, 827, 10.1038/ng1395
Carro, 2004, The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer’s disease, European Journal of Pharmacology, 490, 127, 10.1016/j.ejphar.2004.02.050
Chavez, 1997, Adrenalectomy increases sensitivity to central insulin, Physiology and Behavior, 62, 631, 10.1016/S0031-9384(97)00188-1
Chen, 2011, A critical role for IGF-II in memory consolidation and enhancement, Nature, 469, 491, 10.1038/nature09667
Chesneau, 1997, Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation, Endocrinology, 138, 3444, 10.1210/en.138.8.3444
Clarke, 1986, Insulin is released from rat brain neuronal cells in culture, Journal of Neurochemistry, 47, 831, 10.1111/j.1471-4159.1986.tb00686.x
Clegg, 2005, Reduced anorexi effects of insulin in obesity-prone rats fed a moderate fat diet, American Journal of physiology, 288, R981
Cohen, 2008, P1-231: Correlation of amyloid deposition with local and distal glucose metabolism in cognitively normal elderly, MCI and Alzheimer’s disease, Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association, 4, T279, 10.1016/j.jalz.2008.05.820
Cook, 2003, Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer’s disease is associated with the apolipoprotein E-epsilon4 allele, American Journal of Pathology, 162, 313, 10.1016/S0002-9440(10)63822-9
Cornier, 2008, The metabolic syndrome, Endocrine Reviews, 29, 777, 10.1210/er.2008-0024
Cotero, 2010
Craft, 2009, The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged, Archives of Neurology, 66, 300, 10.1001/archneurol.2009.27
Craft, 1998, Cerebrospinal fluid and plasma insulin levels in Alzheimer’s disease: Relationship to severity of dementia and ApoE genotype, Neurology, 50, 164, 10.1212/WNL.50.1.164
Craft, 2004, Insulin and neurodegenerative disease: Shared and specific mechanisms, LancetNneurology, 3, 169
De Felice, 2009, Protection of synapses against Alzheimer’s-linked toxins: Insulin signaling prevents the pathogenic binding of A_oligomers, Proceedings of the National Academy of Sciences, 106, 1971, 10.1073/pnas.0809158106
de la Monte, 2009, Insulin resistance and Alzheimer’s disease, BMB Rep, 42, 475, 10.5483/BMBRep.2009.42.8.475
de la Monte, 2010, Ceramide-mediated insulin resistance and impairment of cognitive-motor functions, Journal of Alzheimer’s Disease, 21, 967, 10.3233/JAD-2010-091726
de la Monte, 2005, Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer’s disease, Journal of Alzheimer’s Disease, 7, 45, 10.3233/JAD-2005-7106
de la Monte, 2008, Alzheimer’s disease is type 3 diabetes-evidence reviewed, Journal of Diabetes Science and Technology, 2, 1101, 10.1177/193229680800200619
de Quervain, 1998, Stress and glucocorticoids impair retrieval of long-term spatial memory, Nature, 394, 787, 10.1038/29542
Degroot, 2003, Glucose increases hippocampal extracellular acetylcholine levels upon activation of septal GABA receptors, Brain Research, 979, 71, 10.1016/S0006-8993(03)02868-3
Dempsey, 2003, Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: Effect of exogenous IGF-1 and GDNF, Journal of Neurochemistry, 87, 586, 10.1046/j.1471-4159.2003.02022.x
Deng, 2010, New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory?, Nature Reviews Neuroscience, 11, 339, 10.1038/nrn2822
Devaskar, 1994, Insulin gene expression and insulin synthesis in mammalian neuronal cells, Journal of Biological Chemistry, 269, 8445, 10.1016/S0021-9258(17)37214-9
Devaskar, 1993, Insulin II gene expression in rat central nervous system, Regulatory Peptides, 48, 55, 10.1016/0167-0115(93)90335-6
Dhikav, 2007, Glucocorticoids may initiate Alzheimer’s disease: A potential therapeutic role for mifepristone (RU-486), Medical Hypotheses, 68, 1088, 10.1016/j.mehy.2006.09.038
Ding, 2006, Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function, Neuroscience, 140, 823, 10.1016/j.neuroscience.2006.02.084
Dorn, 1982, Insulin-like immunoreactivity in the human brain – A preliminary report, Histochemistry, 74, 293, 10.1007/BF00495838
Dorn, 1982, C-peptide immunoreactive neurons in human brain, Acta Histochemica, 70, 326, 10.1016/S0065-1281(82)80080-9
Drapeau, 2003, Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis, Proceedings of the National Academy of Sciences of the United States of America, 100, 14385, 10.1073/pnas.2334169100
Duffy, 1987, Blood–brain barrier transcytosis of insulin in developing rabbits, Brain Research, 420, 32, 10.1016/0006-8993(87)90236-8
Dupret, 2008, Spatial relational memory requires hippocampal adult neurogenesis, PLoS ONE, 3, e1959, 10.1371/journal.pone.0001959
Eng, 1981, Evidence against extrapancreatic insulin synthesis, Proceedings of the National Academy of Sciences of the United States of America, 78, 4576, 10.1073/pnas.78.7.4576
Erickson, 2006, Septal co-infusions of glucose with a GABAB agonist impair memory, Neurobiology of Learning and Memory, 85, 66, 10.1016/j.nlm.2005.08.008
Ernst, 2006, Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?, Journal of Psychiatry and Neuroscience, 31, 84
Farr, 2008, Obesity and hypertriglyceridemia produce cognitive impairment, Endocrinology, 149, 2628, 10.1210/en.2007-1722
Farris, 2003, Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo, PNAS, 100, 4162, 10.1073/pnas.0230450100
Fontan-Lozano, 2008, Molecular bases of caloric restriction regulation of neuronal synaptic plasticity, Molecular Neurobiology, 38, 167, 10.1007/s12035-008-8040-1
Frank, 1985, Enhanced insulin binding to blood–brain barrier in vivo and to brain microvessels in vitro in newborn rabbits, Diabetes, 34, 728, 10.2337/diabetes.34.8.728
Frolich, 1998, Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease, Journal of Neural Transmission, 105, 423, 10.1007/s007020050068
Gasparini, 2001, Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling, Journal of Neuroscience, 21, 2561, 10.1523/JNEUROSCI.21-08-02561.2001
Gasparini, 2002, Does insulin dysfunction play a role in Alzheimer’s disease?, Trends in Pharmacological Sciences, 23, 288, 10.1016/S0165-6147(02)02037-0
Gerges, 2003, Impaired long-term potentiation in obese zucker rats: Possible involvement of presynaptic mechanism, Neuroscience, 120, 535, 10.1016/S0306-4522(03)00297-5
Gerozissis, 2003, Brain insulin: Regulation, mechanisms of action and functions, Cellular and Molecular Neurobiology, 23, 1, 10.1023/A:1022598900246
Gerozissis, 2004, Brain insulin and feeding: A bi-directional communication, European Journal of Pharmacology, 490, 59, 10.1016/j.ejphar.2004.02.044
Gerozissis, 2008, Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies, European Journal of Pharmacology, 585, 38, 10.1016/j.ejphar.2008.01.050
Gerozissis, K. (2010a). The brain–insulin connection, metabolic diseases and related pathologies. Diabetes, Insulin and Alzheimer’s Disease, Springer Berlin Heidelberg 21–42.
Gerozissis, K. (2010b). The brain–insulin connection, metabolic diseases and related pathologies. Research and Perspectives in Alzheimer’s Disease.
Gerozissis, 1993, Basal and hyperinsulinemia-induced immunoreactive hypothalamic insulin changes in lean and genetically obese Zucker rats revealed by microdialysis, Brain Research, 611, 258, 10.1016/0006-8993(93)90511-K
Gerozissis, 1997, Insulin responses to a fat meal in hypothalamic microdialysates and plasma, Physiology and Behavior, 62, 767, 10.1016/S0031-9384(97)00195-9
Gerozissis, 2001, A potential role of central insulin in learning and memory related to feeding, Cellular and Molecular Neurobiology, 21, 389, 10.1023/A:1012606206116
Gerozissis, 1998, Brain insulin response to feeding in the rat is both macronutrient and area specific, Physiology and Behavior, 65, 271, 10.1016/S0031-9384(98)00158-9
Giddings, 1985, Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues, Diabetologia, 28, 343, 10.1007/BF00283141
Gip, 2004, Glucocorticoids influence brain glycogen levels during sleep deprivation, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 286, R1057, 10.1152/ajpregu.00528.2003
Gispen, 2000, Cognition and synaptic plasticity in diabetes mellitus, Trends in Neuroscience, 542, 10.1016/S0166-2236(00)01656-8
Gispen, 2000, Cognition and synaptic plasticity in diabetes mellitus, Trends in Neurosciences, 23, 542, 10.1016/S0166-2236(00)01656-8
Giuffrida, 2009, Beta-amyloid monomers are neuroprotective, Journal of Neuroscience, 29, 10582, 10.1523/JNEUROSCI.1736-09.2009
Gold, 1995, Role of glucose in regulating the brain and cognition, American Journal of Clinical Nutrition, 61, 987S, 10.1093/ajcn/61.4.987S
Gold, 1995, Role of glucose in regulating the brain and cognition, American Journal of Clinical Nutrition, 61, 987S, 10.1093/ajcn/61.4.987S
Gold, 2005, Glucose and age-related changes in memory, Neurobiology of Aging, 26S, S60, 10.1016/j.neurobiolaging.2005.09.002
Goodner, 1977, The failure of rat hypothalamic tissues to take up labeled insulin in vivo or to respond to insulin in vitro, Endocrinology, 101, 605, 10.1210/endo-101-2-605
Gould, 1999, Learning enhances adult neurogenesis in the hippocampal formation, Nature Neuroscience, 2, 260, 10.1038/6365
Gould, 1991, The hippocampal formation: Morphological changes induced by thyroid, gonadal and adrenal hormones, Psychoneuroendocrinology, 16, 67, 10.1016/0306-4530(91)90071-Z
Greenwood, 1990, Learning and memory impairment in rats fed a high saturated fat diet, Behavioral and Neural Biology, 53, 74, 10.1016/0163-1047(90)90831-P
Greenwood, 2001, Glucose treatment reduces memory deficits in young adult rats fed high-fat diets, Neurobiology of Learning and Memory, 75, 179, 10.1006/nlme.2000.3964
Greenwood, 2005, High-fat diets, insulin resistance and declining cognitive function, Neurobiology of Aging, 26, 42, 10.1016/j.neurobiolaging.2005.08.017
Grillo, 2009, Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent, Brain Research, 1296, 35, 10.1016/j.brainres.2009.08.005
Group, 1991, UKPDS, Diabetologia, 34, 877
Group, 1993, The effect of intensive treatment of diabetes on the development and progression of long-term complications in diabetes mellitus, New England Journal of Medicine, 329, 977, 10.1056/NEJM199309303291401
Haj-ali, 2009, Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats, Behavioral Neuroscience, 123, 1309, 10.1037/a0017722
Hamilton-Wessler, 2002, Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: Evidence for passive diffusion, Diabetes, 51, 574, 10.2337/diabetes.51.3.574
Hasselbalch, 1999, No effect of insulin on glucose blood–brain barrier transport and cerebral metabolism in humans, Diabetes, 48, 1915, 10.2337/diabetes.48.10.1915
Havrankova, 1979, Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents, Journal of Clinical Investigation, 64, 636, 10.1172/JCI109504
Havrankova, 1978, Identification of insulin in rat brain, Proceedings of the National Academy of Sciences of the United States of America, 75, 5737, 10.1073/pnas.75.11.5737
Henneberg, 1994, Short-term or long-term intracerebroventricular (i.c.v.) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat, Neuroscience Letters, 175, 153, 10.1016/0304-3940(94)91102-9
Ho, 2004, Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease, FASEB Journal, 18, 902, 10.1096/fj.03-0978fje
Hoyer, 1996, Brain glucose metabolism is controlled by amplification and desensitization of the neuronal insulin receptor, Annals of the New York Academy of Sciences, 777, 374, 10.1111/j.1749-6632.1996.tb34448.x
Hoyer, 1994, Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism, Journal of Neural Transmission. Supplementum, 44, 259
Huang, 2004, An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus, Journal of Neurochemistry, 89, 217, 10.1111/j.1471-4159.2003.02307.x
Issa, 2006, The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: A systematic review, Dementia and Geriatric Cognitive Disorders, 21, 88, 10.1159/000090224
Izumi, 2003, Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats, Diabetologia, 46, 1007, 10.1007/s00125-003-1144-2
Jacobson, 2007, Long-term effect of diabetes and its treatment on cognitive function, New England Journal of Medicine, 356, 1842, 10.1056/NEJMoa066397
Janson, 2004, Increased risk of type 2 diabetes in Alzheimer disease, Diabetes, 53, 474, 10.2337/diabetes.53.2.474
Julien, 2010, High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model, Neurobiology of Aging, 31, 1516, 10.1016/j.neurobiolaging.2008.08.022
Kamal, 2000, Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Interaction of diabetes and ageing, Diabetologia, 43, 500, 10.1007/s001250051335
King, 1985, Receptor-mediated transport of insulin across endothelial cells, Science, 227, 1583, 10.1126/science.3883490
Kodl, 2008, Cognitive dysfunction and diabetes mellitus, Endocrine Reviews, 29, 494, 10.1210/er.2007-0034
Korol, 1998, Glucose, memory, and aging, American Journal of Clinical Nutrition, 67, 764S, 10.1093/ajcn/67.4.764S
Lafenêtre, P., Leske, O., Ma, Z. L., Haghikia, A., Bichler, Z., Wahle, P., et al. (2009). Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis.
Lang, 2009, Impaired neurogenesis in adult type-2 diabetic rats, Brain Research, 1258, 25, 10.1016/j.brainres.2008.12.026
Laron, 2009, Insulin and the brain, Archives of Physiology and Biochemistry, 115, 112, 10.1080/13813450902949012
Lee, 2009, Insulin rescues amyloid Œ⩽-induced impairment of hippocampal long-term potentiation, Neurobiology of Aging, 30, 377, 10.1016/j.neurobiolaging.2007.06.014
Leibson, 1997, Risk of dementia among persons with diabetes mellitus: A population-based cohort study, American Journal of Epidemiology, 145, 301, 10.1093/oxfordjournals.aje.a009106
Levin, 1980, Abnormal sympatho-adrenal function and plasma catecholamines in obese Zucker rats, Pharmacology, Biochemistry and Behavior, 13, 107, 10.1016/0091-3057(80)90128-8
Liao, 2009, Insulin signaling in sporadic Alzheimer’s disease, Science Signaling, 2, pe36, 10.1126/scisignal.274pe36
Lin, 2000, Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization, Nature Neuroscience, 3, 1282, 10.1038/81814
Lindqvist, 2006, High-fat diet impairs hippocampal neurogenesis in male rats, European Journal of Neurology, 13, 1385, 10.1111/j.1468-1331.2006.01500.x
Luchsinger, 2001, Diabetes mellitus and risk of Alzheimer’s disease and dementia with stroke in a multiethnic cohort, American Journal of Epidemiology, 154, 635, 10.1093/aje/154.7.635
Lupien, 2009, Effects of stress throughout the lifespan on the brain, behaviour and cognition, Nature Reviews Neuroscience, 10, 434, 10.1038/nrn2639
MacLean, 2006, Effects of omega-3 fatty acids on cancer risk: A systematic review, JAMA, 295, 403, 10.1001/jama.295.4.403
Malberg, 2000, Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus, Journal of Neuroscience, 20, 9104, 10.1523/JNEUROSCI.20-24-09104.2000
Man, H. Y., Lin, J. W. Ju, W. H., Ahmadian, G. Liu, L., Becker, L. E., et al. (2000). Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 25(3), 649–662 (erratum appears in Neuron 2001;29(1):307).
Margolis, 1967, Insulin in the cerebrospinal fluid, Nature, 215, 1375, 10.1038/2151375a0
McEwen, 2002, Studies of hormone action in the hippocampal formation: Possible relevance to depression and diabetes, Journal of Psychosomatic Research, 53, 883, 10.1016/S0022-3999(02)00307-0
McGaugh, 2002, Role of adrenal stress hormones in forming lasting memories in the brain, Current Opinion in Neurobiology, 12, 205, 10.1016/S0959-4388(02)00306-9
McNay, 2005, The impact of recurrent hypoglycemia on cognitive function in aging, Neurobiology of Aging, 26, S76, 10.1016/j.neurobiolaging.2005.08.014
McNay, 2006, Modulation of memory with septal injections of morphine and glucose: Effects on extracellular glucose levels in the hippocampus, Physiology and Behavior, 87, 298, 10.1016/j.physbeh.2005.10.016
McNay, 2010, Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function, Physiology and Behavior, 100, 234, 10.1016/j.physbeh.2010.01.004
McNay, E. C., Green, P. K., & Craft, S. (2010). Recurrent hypoglycemia and central insulin resistance: Diverse mechanisms producing hippocampal amyloid accumulation. In ICAD annual meeting, Honolulu, HI.
McNay, 2000, Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task, Proceedings of the National Academy of Sciences of the United States of America, 97, 2881, 10.1073/pnas.050583697
McNay, 1998, Memory modulation across neural systems: Intra-amygdala glucose reverses deficits caused by intraseptal morphine on a spatial task but not on an aversive task, Journal of Neuroscience, 18, 3853, 10.1523/JNEUROSCI.18-10-03853.1998
McNay, 1999, Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: Effects of microdialysis flow rate, strain, and age, Journal of Neurochemistry, 72, 785, 10.1046/j.1471-4159.1999.720785.x
McNay, 2001, Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration, Journals of Gerontology Series A – Biological Sciences and Medical Sciences, 56, B66, 10.1093/gerona/56.2.B66
McNay, 2002, Food for thought: Fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation, Cognitive and Behavioural Neuroscience Reviews, 1, 264, 10.1177/1534582302238337
McNay, 2010, Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance, Neurobiology of Learning and Memory, 93, 546, 10.1016/j.nlm.2010.02.002
McNay, 2010, Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance, Neurobiology of Learning and Memory, 10.1016/j.nlm.2010.02.002
McNay, 2004, Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats, Diabetes, 53, 418, 10.2337/diabetes.53.2.418
McNay, 2006, Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia, Diabetes, 55, 1088, 10.2337/diabetes.55.04.06.db05-1314
Messier, 2004, The relationships between atherosclerosis, heart disease, type 2 diabetes and dementia, Neurological Research, 26, 567, 10.1179/016164104225016263
Mielke, 2005, A biochemical and functional characterization of diet-induced brain insulin resistance, Journal of Neurochemistry, 93, 1568, 10.1111/j.1471-4159.2005.03155.x
Moosavi, 2007, Intra CA1 insulin microinjection improves memory consolidation and retrieval, Peptides, 28, 1029, 10.1016/j.peptides.2007.02.010
Moosavi, 2006, The effect of intrahippocampal insulin microinjection on spatial learning and memory, Hormones and Behavior, 50, 748, 10.1016/j.yhbeh.2006.06.025
Moosavi, 2007, Insulin protects against stress-induced impairments in water maze performance, Behavioural Brain Research, 176, 230, 10.1016/j.bbr.2006.10.011
Morelli, 2004, Insulin-degrading enzyme in brain microvessels: Proteolysis of amyloid beta vasculotropic variants and reduced activity in cerebral amyloid angiopathy, Journal of Biological Chemistry, 279, 56004, 10.1074/jbc.M407283200
Moroz, 2008, Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus, Journal of Alzheimer’s Disease, 15, 29, 10.3233/JAD-2008-15103
Morris, 2003, Dietary fats and the risk of incident Alzheimer disease, Archives of Neurology, 60, 194, 10.1001/archneur.60.2.194
Neumann, 2008, Insulin resistance and Alzheimer’s disease: Molecular links and clinical implications, Current Alzheimer Research, 5, 438, 10.2174/156720508785908919
O’Malley, 2007, MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin, European Journal of Neuroscience, 25, 673, 10.1111/j.1460-9568.2007.05347.x
Ono, 1983, Influence of peripheral and intracerebroventricular glucose and insulin infusions on peripheral and cerebrospinal fluid glucose and insulin levels, Physiology and Behavior, 30, 301, 10.1016/0031-9384(83)90023-9
Oomura, 1975, Effect of free fatty acid on the rat lateral hypothalamic neurons, Physiology and Behavior, 14, 483, 10.1016/0031-9384(75)90015-3
Orosco, 1995, Feeding-related immunoreactive insulin changes in the PVN-VMH revealed by microdialysis, Brain Research, 671, 149, 10.1016/0006-8993(94)01347-K
Orosco, 2000, Activation of hypothalamic insulin by serotonin is the primary event of the insulin–serotonin interaction involved in the control of feeding, Brain Research, 872, 64, 10.1016/S0006-8993(00)02449-5
Ott, 1999, Diabetes mellitus and the risk of dementia, Neurology, 53, 1937, 10.1212/WNL.53.9.1937
Pardridge, 1986, Receptor-mediated peptide transport through the blood–brain barrier, Endocrine Reviews, 7, 314, 10.1210/edrv-7-3-314
Pardridge, 1985, Human blood–brain barrier insulin receptor, Journal of Neurochemistry, 44, 1771, 10.1111/j.1471-4159.1985.tb07167.x
Park, 2000, Intracerebroventricular insulin enhances memory in a passive avoidance task, Physiology and Behaviour, 68, 509, 10.1016/S0031-9384(99)00220-6
Parsons, 1992, Glucose enhancement of memory in elderly humans: An inverted-U dose-response curve, Neurobiology of Aging, 13, 401, 10.1016/0197-4580(92)90114-D
Pedersen, 2006, Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice, Experimental Neurology, 199, 265, 10.1016/j.expneurol.2006.01.018
Piroli, 2002, Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus, Journal of Comparative Neurology, 452, 103, 10.1002/cne.10368
Piroli, 2007, Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus, Neuroendocrinology, 85, 71, 10.1159/000101694
Plata-Salaman, 1991, Insulin in the cerebrospinal fluid, Neuroscience and Biobehavioral Reviews, 15, 243, 10.1016/S0149-7634(05)80004-1
Pocai, 2005, Hypothalamic K(ATP) channels control hepatic glucose production, Nature, 434, 1026, 10.1038/nature03439
Quirarte, 1997, Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala, Proceedings of the National Academy of Sciences of the United States of America, 94, 14048, 10.1073/pnas.94.25.14048
Ramakrishnan, 1995, Norepinephrine and epinephrine levels in the brain of alloxan diabetic rats, Neuroscience Letters, 186, 200, 10.1016/0304-3940(95)11315-N
Ramirez-Amaya, 2006, Integration of new neurons into functional neural networks, Journal of Neuroscience, 26, 12237, 10.1523/JNEUROSCI.2195-06.2006
Reagan, 2005, Neuronal insulin signal transduction mechanisms in diabetes phenotypes, Neurobiology of Aging, 26S, S56, 10.1016/j.neurobiolaging.2005.09.001
Reagan, 2011, Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications, Experimental Neurology, 10.1016/j.expneurol.2011.02.004
Reger, 2006, Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype, Neurobiology of Aging, 27, 451, 10.1016/j.neurobiolaging.2005.03.016
Reger, 2006, Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype, Neurobiology of Aging, 27, 451, 10.1016/j.neurobiolaging.2005.03.016
Reger, 2008, Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults, Journal of Alzheimer’s Disease, 13, 323, 10.3233/JAD-2008-13309
Reger, 2008, Intranasal insulin improves cognition and modulates {beta}-amyloid in early AD, Neurology, 70, 440, 10.1212/01.WNL.0000265401.62434.36
Reiser, 1985, Insulin-like immunoreactivity in human cerebrospinal-fluid is independent of insulin blood levels, Human Neurobiology, 4, 53
Rivera, 2005, Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine, Journal of Alzheimer’s Disease, 8, 247, 10.3233/JAD-2005-8304
Roozendaal, 2002, Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval, Neurobiology of Learning and Memory, 78, 578, 10.1006/nlme.2002.4080
Roozendaal, 2009, Stress, memory and the amygdala, Nature Reviews Neuroscience, 10, 423, 10.1038/nrn2651
Ross, 2009, A high fructose diet impairs spatial memory in male rats, Neurobiology of Learning and Memory, 92, 410, 10.1016/j.nlm.2009.05.007
Santos, 1999, Stimulation of immunoreactive insulin release by glucose in rat brain synaptosomes, Neurochemical Research, 24, 33, 10.1023/A:1020971812098
Sapolsky, 1986, Glucocorticoid toxicity in the hippocampus: Reversal by supplementation with brain fuels, Journal of Neuroscience, 6, 2240, 10.1523/JNEUROSCI.06-08-02240.1986
Schechter, 1996, Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system, Brain Research, 736, 16, 10.1016/0006-8993(96)00664-6
Schechter, 1988, Insulin synthesis by isolated rabbit neurons, Endocrinology, 123, 505, 10.1210/endo-123-1-505
Schechter, 1990, Insulin and insulin mRNA are detected in neuronal cell cultures maintained in an insulin-free/serum-free medium, Journal of Histochemistry and Cytochemistry, 38, 829, 10.1177/38.6.2186089
Schechter, 1994, Immunohistochemical and in situ hybridization study of an insulin-like substance in fetal neuron cell cultures, Brain Research, 636, 9, 10.1016/0006-8993(94)90170-8
Schubert, 2004, Role for neuronal insulin resistance in neurodegenerative diseases, PNAS, 101, 3100, 10.1073/pnas.0308724101
Schubert, 2004, Role for neuronal insulin resistance in neurodegenerative diseases, Proceedings of the National Academy of Sciences of the United States of America, 101, 3100, 10.1073/pnas.0308724101
Schwartz, 1991, Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport, Journal of Clinical Investigation, 88, 1272, 10.1172/JCI115431
Schwartz, 1990, Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid, American Journal of Physiology, 259, E378
Seaquist, 2001, The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans, Diabetes, 50
Shah, 2003, Septal infusions of glucose or pyruvate, but not fructose, produce avoidance deficits when co-infused with the GABA agonist muscimol, Neurobiology of Learning and Memory, 79, 243, 10.1016/S1074-7427(03)00007-8
Skeberdis, 2001, Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis, Proceedings of the National Academy of Sciences, 98, 3561, 10.1073/pnas.051634698
Spanswick, 2000, Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese, rats, Nature Neuroscience, 3, 757, 10.1038/77660
Stangl, 2009, Impact of diet on adult hippocampal neurogenesis, Genes and Nutrition, 4, 271, 10.1007/s12263-009-0134-5
Steen, 2005, Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease: Is this type 3 diabetes?, Journal of Alzheimer’s Disease, 7, 63, 10.3233/JAD-2005-7107
Stefani, 2001, Intrahippocampal infusions of k-atp channel modulators influence spontaneous alternation performance: Relationships to acetylcholine release in the hippocampus, Journal of Neuroscience, 21, 609, 10.1523/JNEUROSCI.21-02-00609.2001
Steffens, 1988, Penetration of peripheral glucose and insulin into cerebrospinal fluid in rats, American Journal of Physiology, 255, R200
Steil, 1996, Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process, Journal of Clinical Investigation, 97, 1497, 10.1172/JCI118572
Stranahan, 2008, Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons, Nature Neuroscience, 11, 309, 10.1038/nn2055
Stranahan, 2010, Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats, Synapse, 64, 528, 10.1002/syn.20758
Stranahan, 2010, Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice, Neurobiology of Aging, 31, 1937, 10.1016/j.neurobiolaging.2008.10.016
Stranahan, 2008, Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels, Neurobiology of Learning and Memory, 90, 479, 10.1016/j.nlm.2008.05.005
Stranahan, 2011, Bidirectional metabolic regulation of neurocognitive function, Neurobiology of Learning and Memory, 10.1016/j.nlm.2011.01.004
Sun, 2006, Links between Alzheimer’s disease and diabetes, Drugs Today (Barcelona), 42, 481, 10.1358/dot.2006.42.7.973588
Townsend, 2007, Soluble A_inhibits specific signal transduction cascades common to the insulin receptor pathway, Journal of Biological Chemistry, 282, 33305, 10.1074/jbc.M610390200
Triguero, 1990, Capillary depletion method for quantification of blood–brain barrier transport of circulating peptides and plasma proteins, Journal of Neurochemistry, 54, 1882, 10.1111/j.1471-4159.1990.tb04886.x
Unger, 1989, Distribution of insulin receptor-like immunoreactivity in the rat forebrain, Neuroscience, 31, 143, 10.1016/0306-4522(89)90036-5
Unger, 1991, Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat, Neuroscience, 42, 853, 10.1016/0306-4522(91)90049-T
van den Berg, 2009, Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition, Biochimica et Biophysica Acta, 1792, 470, 10.1016/j.bbadis.2008.09.004
van den Berg, 2010, A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus, Diabetologia, 53, 58, 10.1007/s00125-009-1571-9
van der Borght, 2011, Reduced neurogenesis in the rat hippocampus following high fructose consumption, Regulatory Peptides, 167, 26, 10.1016/j.regpep.2010.11.002
van der Heide, 2005, Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner, Journal of Neurochemistry, 94, 1158, 10.1111/j.1471-4159.2005.03269.x
Vannucci, 1998, GluT4 glucose transporter expression in rodent brain: Effect of diabetes, Brain Research, 797, 1, 10.1016/S0006-8993(98)00103-6
Vetiska, 2007, GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors, Neuropharmacology, 52, 146, 10.1016/j.neuropharm.2006.06.023
Wallum, 1987, Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man, Journal of Clinical Endocrinology and Metabolism, 64, 190, 10.1210/jcem-64-1-190
Wang, 2006, Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels, Journal of Neurophysiology, 95, 1491, 10.1152/jn.00697.2005
Watson, 2003, The role of insulin resistance in the pathogenesis of Alzheimer’s disease: Implications for treatment, CNS Drugs, 17, 27, 10.2165/00023210-200317010-00003
Watson, 2004, Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease, European Journal of Pharmacology, 490, 97, 10.1016/j.ejphar.2004.02.048
Wei, 1990, Release of immunoreactive insulin from rat brain synaptosomes under depolarizing conditions, Journal of Neurochemistry, 54, 1661, 10.1111/j.1471-4159.1990.tb01219.x
Wei Qiao, 2006, Insulin, insulin-degrading enzyme and amyloid-peptide in Alzheimer’s disease: Review and hypothesis, Neurobiology of Aging, 27, 190, 10.1016/j.neurobiolaging.2005.01.004
Williams, 1993, Reversible lesions of the nucleus of the solitary tract attenuate the memory-modulating effects of posttraining epinephrine, Behavioral Neuroscience, 107, 955, 10.1037/0735-7044.107.6.955
Winocur, 2005, Studies of the effects of high fat diets on cognitive function in a rat model, Neurobiology of Aging, 26, 46, 10.1016/j.neurobiolaging.2005.09.003
Winocur, 2005, Memory impairment in obese Zucker rats: An investigation of cognitive function in an animal model of insulin resistance and obesity, Behavioral Neuroscience, 119, 1389, 10.1037/0735-7044.119.5.1389
Woods, 1977, Relationship between plasma and cerebrospinal fluid insulin levels of dogs, American Journal of Physiology, 233, E331
Woods, 2003, Insulin and the blood–brain barrier, Current Pharmaceutical Design, 9, 795, 10.2174/1381612033455323
Wozniak, 1993, The cellular and physiological actions of insulin in the central nervous system, Neurochemistry International, 22, 1, 10.1016/0197-0186(93)90062-A
Wrighten, 2009, A look inside the diabetic brain: Contributors to diabetes-induced brain aging, Biochimica et Biophysica Acta, 1792, 444, 10.1016/j.bbadis.2008.10.013
Yalow, 1983, Insulin in the central nervous system, Advanced Metabolic Disorders, 10, 341, 10.1016/B978-0-12-027310-2.50018-9
Young, 1986, Periventricular hypothalamic cells in the rat brain contain insulin mRNA, Neuropeptides, 8, 93, 10.1016/0143-4179(86)90035-1
Zhao, 2001, Role of insulin and insulin receptor in learning and memory, Molecular and Cellular Endocrinology, 177, 125, 10.1016/S0303-7207(01)00455-5
Zhao, 2004, Insulin and the insulin receptor in experimental models of learning and memory, European Journal of Pharmacology, 490, 71, 10.1016/j.ejphar.2004.02.045
Zhao, 1999, Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats, Journal of Biological Chemistry, 274, 34893, 10.1074/jbc.274.49.34893
Zhao, 2008, Amyloid beta oligomers induce impairment of neuronal insulin receptors, FASEB Journal, 22, 246, 10.1096/fj.06-7703com
Zhao, 2009, Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}, Journal of Biological Chemistry, 284, 18742, 10.1074/jbc.M109.011015
Zhao, 2004, Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: Implications for Alzheimer’s disease intervention, Journal of Neuroscience, 24, 11120, 10.1523/JNEUROSCI.2860-04.2004
Zhao, 2009, Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer’s disease, Biochimica et Biophysica Acta, 1792, 482, 10.1016/j.bbadis.2008.10.014