Taking Advantage of the Systemic Immune System to Cure Brain Diseases

Ajami, 2007, Local self-renewal can sustain CNS microglia maintenance and function throughout adult life, Nat. Neurosci., 10, 1538, 10.1038/nn2014 Appel, 2008, Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis, Neurology, 71, 1326, 10.1212/01.wnl.0000327668.43541.22 Auffray, 2009, Blood monocytes: development, heterogeneity, and relationship with dendritic cells, Annu. Rev. Immunol., 27, 669, 10.1146/annurev.immunol.021908.132557 Boissonneault, 2009, Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, Brain, 132, 1078, 10.1093/brain/awn331 Burt, 2009, Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study, Lancet Neurol., 8, 244, 10.1016/S1474-4422(09)70017-1 Butovsky, 2006, Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1, Proc. Natl. Acad. Sci. USA, 103, 11784, 10.1073/pnas.0604681103 D'Mello, 2009, Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation, J. Neurosci., 29, 2089, 10.1523/JNEUROSCI.3567-08.2009 Frenkel, 2005, Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease, J. Clin. Invest., 115, 2423, 10.1172/JCI23241 Kang, 2007, MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis, J. Cell Biol., 179, 1219, 10.1083/jcb.200705046 Liesz, 2009, Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke, Nat. Med., 15, 192, 10.1038/nm.1927 Lucin, 2009, Immune activation in brain aging and neurodegeneration: Too much or too little?, Neuron, 64, 110, 10.1016/j.neuron.2009.08.039 Majumdar, 2007, Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils, Mol. Biol. Cell, 18, 1490, 10.1091/mbc.E06-10-0975 Martinez, 2009, Alternative activation of macrophages: an immunologic functional perspective, Annu. Rev. Immunol., 27, 451, 10.1146/annurev.immunol.021908.132532 Mildner, 2007, Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions, Nat. Neurosci., 10, 1544, 10.1038/nn2015 Nahrendorf, 2007, The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions, J. Exp. Med., 204, 3037, 10.1084/jem.20070885 Ray, 2007, Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins, Nat. Med., 13, 1359, 10.1038/nm1653 Richard, 2008, Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, J. Neurosci., 28, 5784, 10.1523/JNEUROSCI.1146-08.2008 Rivest, 2009, Regulation of innate immune responses in the brain, Nat. Rev. Immunol., 9, 429, 10.1038/nri2565 Schwartz, 1999, Innate and adaptive immune responses can be beneficial for CNS repair, Trends Neurosci., 22, 295, 10.1016/S0166-2236(99)01405-8 Shechter, 2009, Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice, PLoS Med., 6, e1000113, 10.1371/journal.pmed.1000113 Simard, 2006, Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, Neuron, 49, 489, 10.1016/j.neuron.2006.01.022 Skihar, 2009, Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0909607106 Soulet, 2008, Bone-marrow-derived microglia: myth or reality?, Curr. Opin. Pharmacol., 8, 508, 10.1016/j.coph.2008.04.002 Town, 2008, Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology, Nat. Med., 14, 681, 10.1038/nm1781 Urushitani, 2007, Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis, Proc. Natl. Acad. Sci. USA, 104, 2495, 10.1073/pnas.0606201104 Yin, 2006, Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells, Nat. Neurosci., 9, 843, 10.1038/nn1701 Yong, 2005, Metalloproteinases: mediators of pathology and regeneration in the CNS, Nat. Rev. Neurosci., 6, 931, 10.1038/nrn1807 Ziv, 2008, Immune-based regulation of adult neurogenesis: implications for learning and memory, Brain Behav. Immun., 22, 167, 10.1016/j.bbi.2007.08.006