Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial

Preshaw, 2012, Periodontitis and diabetes: a two-way relationship, Diabetologia, 55, 21, 10.1007/s00125-011-2342-y D'Aiuto, 2018, Systemic effects of periodontitis treatment in patients with type 2 diabetes. a 12 month randomised controlled clinical trial, Lancet Diabetes Endocrinol., 10.1016/S2213-8587(18)30038-X Tonetti, 2007, Treatment of periodontitis and endothelial function, N. Engl. J. Med., 356, 911, 10.1056/NEJMoa063186 Bullon, 2011, Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis, Free Radic. Biol. Med., 50, 1336, 10.1016/j.freeradbiomed.2011.02.018 Dai, 2012, Mitochondria and cardiovascular aging, Circ. Res., 110, 1109, 10.1161/CIRCRESAHA.111.246140 Sun, 2017, Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes, J. Clin. Periodontol., 44, 463, 10.1111/jcpe.12711 Szendroedi, 2011, The role of mitochondria in insulin resistance and type 2 diabetes mellitus, Nat. Rev. Endocrinol., 8, 92, 10.1038/nrendo.2011.138 Naik, 2011, Mitochondrial reactive oxygen species drive proinflammatory cytokine production, J. Exp. Med., 208, 417, 10.1084/jem.20110367 American Diabetes Association, 2016, Classification and diagnosis of diabetes. Sec 2 in Standards of Medical Care in Diabetes - 2016, Diabetes Care, 39, S13, 10.2337/dc16-S005 NICE, 2017, Type 2 diabetes in adults: management O'Leary, 1972, The plaque control record, J. Periodontol., 43, 38, 10.1902/jop.1972.43.1.38 Bulua, 2011, Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS), J. Exp. Med., 208, 519, 10.1084/jem.20102049 Jitschin, 2014, Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia, Blood, 123, 2663, 10.1182/blood-2013-10-532200 Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663 Mukhopadhyay, 2007, Simple quantitative detection of mitochondrial superoxide production in live cells, Biochem. Biophys. Res. Commun., 358, 203, 10.1016/j.bbrc.2007.04.106 Donald, 2010, Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal Study of Parents and Children (ALSPAC), Eur. Heart J., 31, 1502, 10.1093/eurheartj/ehq062 Sena, 2013, Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling, Immunity, 38, 225, 10.1016/j.immuni.2012.10.020 Weinberg, 2015, Mitochondria in the regulation of innate and adaptive immunity, Immunity, 42, 406, 10.1016/j.immuni.2015.02.002 Billiau, 1996, Interferon-gamma: biology and role in pathogenesis, Adv. Immunol., 62, 61, 10.1016/S0065-2776(08)60428-9 Kroger, 2002, Activities of IRF-1, J. Interf. Cytokine Res., 22, 5, 10.1089/107999002753452610 Ramana, 2002, Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling, Trends Immunol., 23, 96, 10.1016/S1471-4906(01)02118-4 Schroder, 2004, Interferon-gamma: an overview of signals, mechanisms and functions, J. Leukoc. Biol., 75, 163, 10.1189/jlb.0603252 Zhang, 2007, Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease, J. Clin. Invest., 117, 871, 10.1172/JCI31860 Zhang, 2011, Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils, PLoS One, 6 Hernandez-Mijares, 2013, Human leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2 diabetic patients and their association with silent myocardial ischemia, Diabetes Care, 36, 1695, 10.2337/dc12-1224 Sikorski, 2011, STAT1-mediated signal integration between IFNgamma and LPS leads to increased EC and SMC activation and monocyte adhesion, Am. J. Phys. Cell Phys., 300, C1337, 10.1152/ajpcell.00276.2010 Widlansky, 2010, Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes, Transl. Res., 156, 15, 10.1016/j.trsl.2010.04.001 Zhang, 2008, Association between PPARGC1A gene polymorphisms and coronary artery disease in a Chinese population, Clin. Exp. Pharmacol. Physiol., 35, 1172, 10.1111/j.1440-1681.2008.04988.x Wang, 2014, The effect of periodontal treatment on hemoglobin a1c levels of diabetic patients: a systematic review and meta-analysis, PLoS One, 9 Murphy, 2009, How mitochondria produce reactive oxygen species, Biochem. J., 417, 1, 10.1042/BJ20081386 Anderson, 2009, Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans, J. Clin. Invest., 119, 573, 10.1172/JCI37048 Chen, 2008, Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice, Aging Cell, 7, 866, 10.1111/j.1474-9726.2008.00432.x Hoehn, 2009, Insulin resistance is a cellular antioxidant defense mechanism, Proc. Natl. Acad. Sci. U. S. A., 106, 17787, 10.1073/pnas.0902380106 Houstis, 2006, Reactive oxygen species have a causal role in multiple forms of insulin resistance, Nature, 440, 944, 10.1038/nature04634 Lee, 2010, Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance, Cell Metab., 12, 668, 10.1016/j.cmet.2010.11.004 Nakamura, 2009, Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria, J. Biol. Chem., 284, 14809, 10.1074/jbc.M901488200 Donald, 2008, Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation, J. Am. Coll. Cardiol., 51, 1959, 10.1016/j.jacc.2008.02.044