Acidic polysaccharide isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C

Kim, 2003, Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M. A. Curtis) Teng, Biores. Technol., 87, 81, 10.1016/S0960-8524(02)00273-0 Han, 1999, The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis, Immunopharmacology, 41, 157, 10.1016/S0162-3109(98)00063-0 Kim, 1996, Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus, Int. J. Immunopharmacol., 18, 295, 10.1016/0192-0561(96)00028-8 Hahn, 1981, The role of cell-mediated immunity in bacterial infections, Rev. Infect. Dis., 3, 1221, 10.1093/clinids/3.6.1221 Verstovsek, 1992, Tumoricidal activation of murine resident peritoneal macrophage by interleukin 2 and tumor necrosis factor, Cancer Res., 52, 3880 Fidler, 1993, Therapy of cancer metastasis by systemic activation of macrophages; from bench to the clinic, Res. Immunol., 144, 274, 10.1016/0923-2494(93)80109-C Zirk, 1999, The polysaccharide portion of lipopolysaccharide regulates antigen-specific T-cell activation via effects on macrophage-mediated antigen processing, Infect. Immun., 67, 319, 10.1128/IAI.67.1.319-326.1999 Stuehr, 1987, Synthesis of nitrite and nitrate in macrophage cell lines, Cancer Res., 47, 5590 Choriki, 1989, Antitumoral effects of lipopolysaccharide, tumor necrosis factor, interferon and activated macrophages: synergism and tissue distribution, Anticancer Res., 9, 1185 Keller, 1990, Lymphokines and bacteria that induce tumoricidal activity, trigger a different secretary response in macrophages, Eur. J. Immunol., 20, 690, 10.1002/eji.1830200334 Adachi, 1994, Enhancement of cytokine production by macrophages stimulated with (1→3)-β-glucan, Grifolan (GRN), isolated from Grifola frondosa, Biol. Pharm. Bull., 17, 1554, 10.1248/bpb.17.1554 Vilcek, 1991, Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions, J. Biol. Chem., 266, 7313, 10.1016/S0021-9258(20)89445-9 Lowenstein, 1993, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 90, 9730, 10.1073/pnas.90.20.9730 Nathan, 1987, Secretory products of macrophages, J. Clin. Invest., 79, 319, 10.1172/JCI112815 Lowenstein, 1994, Nitric oxide: a physiologic messenger, Ann. Intern. Med., 120, 227, 10.7326/0003-4819-120-3-199402010-00009 Duerksen-Hughes, 1992, Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages, J. Immunol., 149, 2114 Lorsbach, 1993, Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide, J. Biol. Chem., 268, 1908, 10.1016/S0021-9258(18)53940-5 Stuehr, 1989, Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cell, J. Exp. Med., 169, 1543, 10.1084/jem.169.5.1543 Farias-Eisner, 1994, Nitric oxide is an important mediator for tumoricidal activity in vivo, Proc. Natl. Acad. Sci. USA, 91, 9407, 10.1073/pnas.91.20.9407 Gupta, 1995, Peptidoglycan induces transcription and secretion of TNF-α and activation of Lyn, extracellular signal-regulated kinase, and Rsk signal transduction proteins in mouse macrophages, J. Immunol., 155, 2620 Dong, 1993, Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein–tyrosine kinase activity, J. Leukocyte Biol., 53, 53, 10.1002/jlb.53.1.53 Um, 1993, Involvement of protein kinase C and tyrosine kinase in tumoricidal activation of macrophage induced by Streptococcus pneumoniae type II capsular polysaccharide, Int. Immunopharmacol., 5, 1119 Doherty, 2000, Innate and adaptive lymphoid cells in the human lever, Immunol. Rev., 174, 5, 10.1034/j.1600-0528.2002.017416.x Ross, 1993, CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions, Clin. Exp. Immunol., 92, 181, 10.1111/j.1365-2249.1993.tb03377.x Renzo, 1991, The function of human NK cells is enhanced by β-glucan, a ligand of CR3 (CD11b/CD18), Eur. J. Immunol., 21, 1755, 10.1002/eji.1830210726 Thornton, 1996, Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18), J. Immunol., 156, 1235 Sallusto, 1995, Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products, J. Exp. Med., 182, 389, 10.1084/jem.182.2.389 Noorman, 1997, Inhibition of mannose receptor-mediated clearance of tissue-type plasminogen activator (t-PA) by dextran: a new explanation for its antithrombotic effect, Thromb. Haemastasis, 78, 1249, 10.1055/s-0038-1657723 Taguchi, 1985, Endo-point results of phase III study of lentinan, Jpn. J. Cancer Chemother., 12, 366 Okamura, 1986, Clinical evaluation of Shizophyllan combined with irradiation in patients with cervical cancer. A randomized controlled study, Cancer, 58, 865, 10.1002/1097-0142(19860815)58:4<865::AID-CNCR2820580411>3.0.CO;2-S Kim, 2003, Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase, Int. Immunopharmacol., 506, 1281, 10.1016/S1567-5769(03)00115-2 Lichtenfels, 1994, CARE-LASS (calcein-release assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity, J. Immunol. Methods, 172, 227, 10.1016/0022-1759(94)90110-4 Cho, 2002, The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide, Carcinogenesis, 23, 1163, 10.1093/carcin/23.7.1163 Hibbs, 1987, Macrophage cytotoxicity: role for l-arginine deaminase and imino nitrogen oxidation to nitrite, Science, 235, 473, 10.1126/science.2432665 MacMicking, 1995, Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase, Cell, 81, 641, 10.1016/0092-8674(95)90085-3 Yim, 1993, Macrophage nitric oxide synthesis delays progression of ultraviolet light-induced murine skin cancers, Cancer Res., 53, 5507 Farias-Eisner, 1994, Nitric oxide is an important mediator for tumoricidal activity in vivo, Proc. Natl. Acad. Sci. USA, 91, 9407, 10.1073/pnas.91.20.9407 Xie, 1995, Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells, J. Exp. Med., 181, 1333, 10.1084/jem.181.4.1333 Goenka, 1998, Protein A induces no production: involvement of tyrosine kinase, phospholipase c, and protein kinase C, Biochem. Biophys. Res. Commun., 250, 425, 10.1006/bbrc.1998.9324 Peter-Golden, 1991, Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism, Am. J. Physiol., 261, 462 Shishodia, 1998, Protein kinase C: a potential pathway of macrophage activation with cisplatin, Immunol. Lett., 61, 179, 10.1016/S0165-2478(98)00017-0 Zhang, 2002, Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum, Life Sci., 71, 623, 10.1016/S0024-3205(02)01690-9 Czop, 1991, Isolation and characterization of β-glucan receptors on human mononuclear phagocytes, J. Exp. Med., 173, 1511, 10.1084/jem.173.6.1511 Zimmerman, 1999, A novel carbohydrate–glycosphingolipid interaction between a β-(1–3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes, J. Biol. Chem., 273, 22014, 10.1074/jbc.273.34.22014 Xia, 1999, The β-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells, J. Immunol., 162, 2281 Petty, 1993, Receptor–receptor interactions of complement receptor type 3 in neutrophil membranes, J. Leukocyte Biol., 54, 492, 10.1002/jlb.54.5.492 Brown, 1996, Where the outside meets the inside: integrins as activators and targets of signal transduction cascades, Immunol. Lett., 54, 189, 10.1016/S0165-2478(96)02671-5 Newton, 1997, Signaling mechanisms and the activation of leukocyte integrins, J. Leukocyte Biol., 61, 422, 10.1002/jlb.61.4.422