Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study
Heinz Gisslinger1, Christoph Klade2, Pencho Georgiev3, Dorota Krochmalczyk4, Liana Gercheva-Kyuchukova5, Miklos Egyed6, Viktor Rossiev7, Petr Dulicek8, Arpad Illes9, Halyna Pylypenko10, Lylia Sivcheva11, Jiri Mayer12, Vera Yablokova13, Kurt Krejcy2, Barbara Grohmann-Izay2, Hans C Hasselbalch14, Robert Kralovics15,16, Jean-Jacques Kiladjian17,18
1Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University Vienna, Vienna, Austria
2AOP Orphan Pharmaceuticals AG, Vienna, Austria;
3University Multiprofile Hospital for Active Treatment “Sveti Georgi”, Clinic of Haematology, Medical University of Plovdiv, Plovdiv, Bulgaria
4Teaching Unit of the Haematology Department, University Hospital in Krakow, Krakow, Poland
5Multiprofile Hospital for Active Treatment “Sveta Marina”, Clinical Haematology Clinic, Varna, Bulgaria
6Department of Internal Medicine II, Kaposi MorCounty Teaching Hospital, Kaposvar, Hungary
7Samara Kalinin Regional Clinical Hospital, Samara, Russia
8Department of Clinical Haematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
9Department of Haematology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
10Department of Haematology, Regional Treatment and Diagnostics Haematology Centre, Cherkasy Regional Oncology Centre, Cherkasy, Ukraine
11Multiprofile Hospital for Active Treatment—HristoBotev, First Department of Internal Medicine, Vratsa, Bulgaria
12Clinic of Internal Medicine—Haematology and Oncology, University Hospital Brno, Brno, Czech Republic
13Yaroslavl Regional Clinical Hospital, Department of Haematology, Yaroslavl, Russia
14Department of Haematology, Zealand University Hospital, Roskilde, University of Copenhagen, Denmark
15Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria
16CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
17Université de Paris, CIC 1427, Inserm, F-75010, Paris, France
18Centre d'Investigations Cliniques, AP-HP, Hopital Saint-Louis, F-75010, Paris, France
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The Lancet Haematology
Tập 7
e196-e208
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