Innate immune receptor expression in normal brain aging

Asea, 2000, HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine, Nat Med, 6, 435, 10.1038/74697

Asea, 2002, Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4, J Biol Chem, 277, 15028, 10.1074/jbc.M200497200

Blalock, 2003, Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment, J Neurosci, 23, 3807, 10.1523/JNEUROSCI.23-09-03807.2003

Boehmer, 2005, Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway, Mech Ageing Dev, 126, 1305, 10.1016/j.mad.2005.07.009

Bsibsi, 2002, Broad expression of Toll-like receptors in the human central nervous system, J Neuropathol Exp Neurol, 61, 1013, 10.1093/jnen/61.11.1013

Calabrese, 2005, Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich’s ataxia, J Neurol Sci, 233, 145, 10.1016/j.jns.2005.03.012

Candore, 2006, Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4, Ann N Y Acad Sci, 1067, 282, 10.1196/annals.1354.037

Chelvarajan, 2005, The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function, J Leukoc Biol, 77, 503, 10.1189/jlb.0804449

Chen, 2006, Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide, J Biol Chem, 281, 3651, 10.1074/jbc.M508125200

Dybdahl, 2002, Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4, Circulation, 105, 685, 10.1161/hc0602.103617

Fassbender, 2004, The LPS receptor (CD14) links innate immunity with Alzheimer’s disease, FASEB J, 18, 203, 10.1096/fj.03-0364fje

Finch, 2003, Neurons, glia, and plasticity in normal brain aging, Neurobiol Aging, 24, S123, 10.1016/S0197-4580(03)00051-4

Fortun, 2001, Monocytes influence the fate of T cells challenged with oxidised low density lipoproteins towards apoptosis or MHC-restricted proliferation, Atherosclerosis, 156, 11, 10.1016/S0021-9150(00)00575-X

Franceschi, 2000, Inflamm-aging, Ann N Y Acad Sci, 908, 244, 10.1111/j.1749-6632.2000.tb06651.x

Frantz, 2001, Role of TLR-2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes, J Biol Chem, 276, 5197, 10.1074/jbc.M009160200

Geula, 1998, Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity, Nat Med, 4, 827, 10.1038/nm0798-827

Godbout, 2004, Interleukin-6 in the aging brain, J Neuroimmunol, 147, 141, 10.1016/j.jneuroim.2003.10.031

Holvoet, 2006, Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells, Arterioscler Thromb Vasc Biol, 26, 1558, 10.1161/01.ATV.0000226553.01555.02

Kato, 1998, Immunohistochemical detection of dityrosine in lipofuscin pigments in the aged human brain, FEBS Lett, 439, 231, 10.1016/S0014-5793(98)01372-6

Keller, 2005, Age-related neuropathology, cognitive decline, and Alzheimer’s disease, Ageing Res Rev, 5, 1, 10.1016/j.arr.2005.06.002

Keller, 2004, Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain, Int J Biochem Cell Biol, 36, 2376, 10.1016/j.biocel.2004.05.003

Keller, 2002, The proteasome in brain aging, Ageing Res Rev, 1, 279, 10.1016/S1568-1637(01)00006-X

Laflamme, 2001, Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS, J Neurochem, 79, 648, 10.1046/j.1471-4159.2001.00603.x

Lee, 2000, Gene-expression profile of the ageing brain in mice, Nat Genet, 25, 294, 10.1038/77046

Liu, 2005, LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide, Brain, 128, 1778, 10.1093/brain/awh531

Lu, 2004, Gene regulation and DNA damage in the ageing human brain, Nature, 429, 883, 10.1038/nature02661

Miller, 2003, Oxidized low density lipoprotein and innate immune receptors, Curr Opin Lipidol, 14, 437, 10.1097/00041433-200310000-00004

Mishra, 2006, Expression and distribution of Toll-like receptors in the brain during murine neurocysticercosis, J Neuroimmunol, 181, 46, 10.1016/j.jneuroim.2006.07.019

Morrison, 1997, Life and death of neurons in the aging brain, Science, 278, 412, 10.1126/science.278.5337.412

Renshaw, 2002, Cutting edge: impaired Toll-like receptor expression and function in aging, J Immunol, 169, 4697, 10.4049/jimmunol.169.9.4697

Stewart, 2005, Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4, Brain Behav Immun, 19, 389, 10.1016/j.bbi.2005.04.003

Streit, 2004, Dystrophic microglia in the aging human brain, Glia, 45, 208, 10.1002/glia.10319

Tahara, 2006, Role of toll-like receptor signalling in A{beta} uptake and clearance, Brain, 129, 3006, 10.1093/brain/awl249

Terman, 1998, Lipofuscin: mechanisms of formation and increase with age, APMIS, 106, 265, 10.1111/j.1699-0463.1998.tb01346.x

Terman, 2006, Oxidative stress, accumulation of biological “garbage,” and aging, Antioxid Redox Signal, 8, 197, 10.1089/ars.2006.8.197

Vabulas, 2001, Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells, J Biol Chem, 276, 31332, 10.1074/jbc.M103217200

Vabulas, 2002, HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway, J Biol Chem, 277, 15107, 10.1074/jbc.M111204200

Vabulas, 2002, The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway, J Biol Chem, 277, 20847, 10.1074/jbc.M200425200

Vabulas, 2002, Heat shock proteins as ligands of toll-like receptors, Curr Top Microbiol Immunol, 270, 169

Walter, 2006, The LPS receptor, CD14 in experimental autoimmune encephalomyelitis and multiple sclerosis, Cell Physiol Biochem, 17, 167, 10.1159/000092078

Walton, 2003, Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2, Arterioscler Thromb Vasc Biol, 23, 1197, 10.1161/01.ATV.0000079340.80744.B8

Walton, 2003, Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8, J Biol Chem, 278, 29661, 10.1074/jbc.M300738200

Yamamoto, 2002, Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging, Am J Pathol, 161, 1805, 10.1016/S0002-9440(10)64457-4

Ye, 2001, An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice, Neuroimmunomodulation, 9, 183, 10.1159/000049025