Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist

Abramowski, 1995, Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera, Neuropharmacology, 34, 1635, 10.1016/0028-3908(95)00138-7 Aramori, 1992, Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells, Neuron, 8, 757, 10.1016/0896-6273(92)90096-V Bagdy, 1992, Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations, Eur. J. Pharmacol., 229, 9, 10.1016/0014-2999(92)90279-D Barnes, 1999, A review of central 5-HT receptors and their function, Neuropharmacology, 38, 1083, 10.1016/S0028-3908(99)00010-6 Berendsen, 1990, Involvement of 5-HT1C-receptors in drug-induced penile erections in rats, Psychopharmacology, 101, 57, 10.1007/BF02253718 Bonhaus, 1999, RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist, Br. J. Pharmacol., 127, 1075, 10.1038/sj.bjp.0702632 Bonhaus, 1999, RS-127445, a selective 5-HT2B receptor antagonist, blocks mCPP-evoked plasma protein extravasation in dura mater and capsaicin-evoked c-fos expression in trigeminal nucleus caudalis of rat, vol. 9 Bylund, 1988, Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype, J. Pharmacol. Exp. Ther., 245, 600 Cheng, 1973, Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50% inhibition of an enzymatic reaction, Biochem. Pharmacol., 22, 3099, 10.1016/0006-2952(73)90196-2 Higgins, 2001, Influence of the 5-HT2C receptor antagonist SB242084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine, Br. J. Pharmacol., 133, 459, 10.1038/sj.bjp.0704082 Kahn, 1991, m-Chlorophenylpiperazine as a probe of serotonin function, Biol. Psychiatry, 30, 1139, 10.1016/0006-3223(91)90184-N Kennett, 1993, 5-HT1C receptors and their therapeutic relevance, Curr. Opin. Investig. Drugs, 2, 317 Kennett, 1997, SB242084, a selective and brain penetrant 5-HT2C receptor antagonist, Neuropharmacology, 36, 609, 10.1016/S0028-3908(97)00038-5 Klodzinska, 1992, Hyperthermia induced by m-trifluoromethylpiperazine (TFMPP) or m-chlorophenylpiperazine (m-CPP) in heat-adapted rats, Psychopharmacology, 109, 466, 10.1007/BF02247725 Lowry, 1951, Protein measurement with the folinphenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 Lucki, 1989, Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity, J. Pharmacol. Exp. Ther., 249, 155 Martin, 1998, 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential, J. Pharmacol. Exp. Ther., 286, 913 Millan, 1997, 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists, Eur. J. Pharmacol., 325, 9, 10.1016/S0014-2999(97)89962-1 Pazos, 1985, The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site, Eur. J. Pharmacol., 106, 539, 10.1016/0014-2999(84)90057-8 Peroutka, 1986, Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B and 5-HT1C binding sites in rat frontal cortex, J. Neurochem., 47, 529, 10.1111/j.1471-4159.1986.tb04532.x Shen, 1993, Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype, J. Biol. Chem., 268, 18200, 10.1016/S0021-9258(17)46830-X Ullmer, 1995, Expression of serotonin receptor mRNAs in blood vessels, FEBS Lett., 370, 215, 10.1016/0014-5793(95)00828-W Vickers, 2001, Modulation of 5-HT2A receptor-mediated head-twitch behavior in the rat by 5-HT2C receptor agonists, Pharmacol. Biochem. Behav., 69, 643, 10.1016/S0091-3057(01)00552-4 Waeber, 1988, Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes, Naunyn-Schmiedeberg's Arch. Pharmacol., 337, 595, 10.1007/BF00175783