The Intracellular Location of Iron Regulatory Proteins Is Altered as a Function of Iron Status in Cell Cultures and Rat Brain

The Journal of Nutrition - Tập 131 Số 11 - Trang 2831-2836 - 2001
Domingo J. Piñero1, Ning Li1, Jing Hu1, James R. Connor1, John L. Beard2
1Department of Neuroscience and Anatomy, G.M. Leader Family Laboratory for Alzheimer's Disease Research, Penn State University College of Medicine, Hershey, PA 17033
2Nutrition Department, The Pennsylvania State University, University Park, PA 16814

Tóm tắt

Từ khóa


Tài liệu tham khảo

Cairo, 2000, Iron regulatory proteins in pathology, Biochem. J, 352, 241, 10.1042/bj3520241

Eisenstein, 2000, Iron regulatory proteins and the molecular control of mammalian iron metabolism, Annu. Rev. Nutr, 20, 627, 10.1146/annurev.nutr.20.1.627

Seiser, 1995, Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA, J. Biol. Chem, 270, 29400, 10.1074/jbc.270.49.29400

Linder, 1992, Ferritin synthesis on polyribosomes attached to the endoplasmic reticulum, J. Inorg. Biochem, 47, 229, 10.1016/0162-0134(92)84068-X

Madani, 1992, Differential effects of iron and inflammation on ferritin synthesis on free and membrane-bound polyribosomes of rat liver, Arch. Biochem. Biophys, 299, 206, 10.1016/0003-9861(92)90265-X

Beard, 1993, Brain iron: location and function, Prog. Food Nutr. Sci, 17, 183

Connor, 1995, A histochemical study of iron-positive cells in the developing rat brain, J. Comp. Neurol, 355, 111, 10.1002/cne.903550112

Roskams, 1994, Iron, transferrin, and ferritin in the rat brain during development and aging, J. Neurochem, 63, 709, 10.1046/j.1471-4159.1994.63020709.x

Taylor, 1990, Developmental changes in transferrin and iron uptake by the brain in the rat, Dev. Brain Res, 55, 35, 10.1016/0165-3806(90)90103-6

Felt, 1996, Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development, J. Nutr, 126, 693, 10.1093/jn/126.3.693

Lozoff, 2000, Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy, Pediatrics, 105, E51, 10.1542/peds.105.4.e51

Piñero, 2001, Variations in Dietary Iron Alter Behavior in Developing Rats, J Nutr, 131, 311, 10.1093/jn/131.2.311

Bartzokis, 2000, In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging, Arch. Gen. Psychiatry, 57, 47, 10.1001/archpsyc.57.1.47

Connor, 1992, A histochemical study of iron, transferrin and ferritin in Alzheimer's diseased brains, J. Neurosci. Res, 31, 75, 10.1002/jnr.490310111

Connor, 1992, Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease, J. Neurosci. Res, 31, 327, 10.1002/jnr.490310214

Connor, 1995, A quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzeimer's diseased brains, J. Neurochem, 65, 717, 10.1046/j.1471-4159.1995.65020717.x

Dexter, 1991, Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia, Brain, 114, 1953, 10.1093/brain/114.4.1953

Sofic, 1991, Selective increase of iron in substantia nigra zona compacta of Parkinsonian brains, J. Neurochem, 56, 978, 10.1111/j.1471-4159.1991.tb02017.x

Hu, 1996, Demonstration and characterization of the iron regulatory protein in human brain, J. Neurochem, 67, 838, 10.1046/j.1471-4159.1996.67020838.x

Piñero, 2000, Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains, Cell. Mol. Biol. (Noisy-le-grand), 46, 761

LaVaute, 2001, Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice, Nat. Genet, 27, 209, 10.1038/84859

Piñero, 2000, Variations in dietary iron alter brain iron metabolism in developing rats, J. Nutr, 130, 254, 10.1093/jn/130.2.254

Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem, 162, 156, 10.1016/0003-2697(87)90021-2

Chen, 1997, Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver, J. Nutr, 127, 238, 10.1093/jn/127.2.238

Chen, 1998, Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver, J. Nutr, 128, 525, 10.1093/jn/128.3.525

Leibold, 2001, Immunolocalization of iron regulatory protein expression in the murine central nervous system, Histochem. Cell Biol, 115, 195, 10.1007/s004180000246