Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation
Christopher S. Smillie1,2,3, Jenny Sauk4,5, Dirk Gevers1, Jonathan Friedman6, Jaeyun Sung1,5,7, Ilan Youngster8,9, Elizabeth L. Hohmann5,9, Christopher Staley10, Alexander Khoruts10,11,12, Michael J. Sadowsky10, Jessica R. Allegretti13, Mark B. Smith3,14, Ramnik J. Xavier1,3,4,5,7, Eric J. Alm1,3,14,15
1Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Computational and Systems Biology, MIT, Cambridge, MA, USA
3The Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA
4Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
5Harvard Medical School, Boston, MA, USA
6Department of Physics, MIT, Cambridge, MA, USA
7Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
8Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA
9Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
10BioTechnology Institute, University of Minnesota, St. Paul, MN, USA
11Division of Gastroenterology, University of Minnesota, St. Paul, MN, USA
12Center for Immunology, University of Minnesota, St. Paul, MA, USA
13Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA
14Finch Therapeutics, Somerville, MA, USA
15Department of Biological Engineering, MIT, Cambridge, MA, USA
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Cell Host & Microbe
Tập 23
229-240.e5
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