Effector/memory CD4 T cells making either Th1 or Th2 cytokines commonly co-express T-bet and GATA-3

PLoS ONE - Tập 12 Số 10 - Trang e0185932
Arundhoti Das1, Vidya Ranganathan1, Danish Umar1, Shipra Thukral1, Anna George1, Satyajit Rath1, Vineeta Bal1
1National Institute of Immunology, New Delhi India

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J Zhu, 2010, CD4+ T cell plasticity-Th2 cells join the crowd, Immunity, 32, 11, 10.1016/j.immuni.2010.01.001

B Zygmunt, 2011, T helper cell differentiation more than just cytokines, Adv Immunol, 109, 159, 10.1016/B978-0-12-387664-5.00005-4

J Rengarajan, 2000, Transcriptional regulation of Th1/Th2 polarization, Immunol Today, 21, 479, 10.1016/S0167-5699(00)01712-6

C Garlanda, 2009, TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization, Trends Immunol, 30, 439, 10.1016/j.it.2009.06.001

SG Rhodes, 2002, Is “timing” important for cytokine polarization?, Trends Immunol, 23, 246, 10.1016/S1471-4906(02)02200-7

J Mudter, 2003, The role of signal transducers and activators of transcription in T inflammatory bowel diseases, Inflamm Bowel Dis, 9, 332, 10.1097/00054725-200309000-00008

R Yagi, 2011, An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation, Int Immunol, 23, 415, 10.1093/intimm/dxr029

S Romagnani, 1991, Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease, Int J Clin Lab Res, 21, 152

A Corthay, 2006, A three-cell model for activation of naïve T helper cells, Scand J Immunol, 64, 93, 10.1111/j.1365-3083.2006.01782.x

HH Smits, 2002, Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development, J Immunol Baltim Md 1950, 168, 1710

T Owaki, 2006, IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways, J Immunol Baltim Md 1950, 177, 7579

M Hata, 2009, Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2), Immunol Lett, 126, 29, 10.1016/j.imlet.2009.07.008

A Wesa, 2007, Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient TH1-type antimelanoma CD4+ T cell responses in vitro, J Immunother Hagerstown Md 1997, 30, 75

C Preuße, 2012, Immune-Mediated Necrotizing Myopathy Is Characterized by a Specific Th1-M1 Polarized Immune Profile, Am J Pathol

M Okamoto, 2009, Mina, an Il4 repressor, controls T helper type 2 bias, Nat Immunol, 10, 872, 10.1038/ni.1747

J Zhu, 2010, Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors, Immunol Rev, 238, 247, 10.1111/j.1600-065X.2010.00951.x

Y Bian, 2005, The capacity of the natural ligands for CD28 to drive IL-4 expression in naïve and antigen-primed CD4+ and CD8+, T cells. Int Immunol, 17, 73, 10.1093/intimm/dxh188

J Yagi, 2006, Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells, Int Immunol, 18, 1681, 10.1093/intimm/dxl102

MH Lexberg, 2010, IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells, Eur J Immunol, 40, 3017, 10.1002/eji.201040539

KJ Oestreich, 2012, Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors, Nat Rev Immunol, 12, 799, 10.1038/nri3321

A Peck, 2010, Plasticity of T-cell phenotype and function: the T helper type 17 example, Immunology, 129, 147, 10.1111/j.1365-2567.2009.03189.x

L Cosmi, 2010, Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4, J Allergy Clin Immunol, 125, 222, 10.1016/j.jaci.2009.10.012

M Peine, 2013, Stable T-bet+GATA-3+ Th1/Th2 Hybrid Cells Arise In Vivo, Can Develop Directly from Naive Precursors, and Limit Immunopathologic Inflammation, PLoS Biol, 11, e1001633, 10.1371/journal.pbio.1001633

S Becattini, 2015, Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines, Science, 347, 400, 10.1126/science.1260668

M Messi, 2003, Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes, Nat Immunol, 4, 78, 10.1038/ni872

A Chaudhry, 2009, HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway, J Immunol Baltim Md 1950, 183, 2415

S Pearson-White, 2003, Defective T-Cell Activation Is Associated with Augmented Transforming Growth Factor Sensitivity in Mice with Mutations in the Sno Gene, Mol Cell Biol, 23, 5446, 10.1128/MCB.23.15.5446-5459.2003

P Li, 2012, BATF–JUN is critical for IRF4-mediated transcription in T cells, Nature, 490, 543, 10.1038/nature11530

J-X Lin, 2012, Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function, Immunity, 36, 586, 10.1016/j.immuni.2012.02.017

AS Saini, 2014, Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells, Nat Immunol

M Upadhyay, 2014, CD40 Signaling Drives B Lymphocytes Into an Intermediate Memory-Like State, Poised Between Naïve and Plasma Cells, J Cell Physiol

KJ Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods San Diego Calif, 25, 402, 10.1006/meth.2001.1262

H-R Park, 2011, Lasting effects of an impairment of Th1-like immune response in γ-irradiated mice: A resemblance between irradiated mice and aged mice, Cell Immunol, 267, 1, 10.1016/j.cellimm.2010.10.004

S Rane, 2014, Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function, BMC Biol, 12, 106, 10.1186/s12915-014-0106-0

JP Brewer, 1999, Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice, Am J Respir Crit Care Med, 160, 1150, 10.1164/ajrccm.160.4.9806034

GS Whitehead, 2003, Allergen-induced airway disease is mouse strain dependent, Am J Physiol—Lung Cell Mol Physiol, 285, L32, 10.1152/ajplung.00390.2002

M Mohrs, 2001, Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter, Immunity, 15, 303, 10.1016/S1074-7613(01)00186-8

M Hirata, 2001, Schistosoma japonicum egg granuloma formation in the interleukin-4 or interferon-gamma deficient host, Parasite Immunol, 23, 271, 10.1046/j.1365-3024.2001.00382.x

CS Hsieh, 1995, T cell genetic background determines default T helper phenotype development in vitro, J Exp Med, 181, 713, 10.1084/jem.181.2.713

A O’Garra, 1998, Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets, Immunity, 8, 275, 10.1016/S1074-7613(00)80533-6

NA Hosken, 1995, The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model, J Exp Med, 182, 1579, 10.1084/jem.182.5.1579

PR Rogers, 2000, CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen, J Immunol Baltim Md 1950, 164, 2955

G Iezzi, 1999, The interplay between the duration of TCR and cytokine signaling determines T cell polarization, Eur J Immunol, 29, 4092, 10.1002/(SICI)1521-4141(199912)29:12<4092::AID-IMMU4092>3.0.CO;2-A

AN Hegazy, 2010, Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions, Immunity, 32, 116, 10.1016/j.immuni.2009.12.004

D Califano, 2014, Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis, J Clin Invest, 124, 174, 10.1172/JCI70103

C Dong, 2000, Control of T helper cell differentiation—in search of master genes, Sci STKE Signal Transduct Knowl Environ, 2000, pe1

FY Liew, 2002, TH1 and TH2 cells: a historical perspective, Nat Rev Immunol, 2, 55, 10.1038/nri705

RG Jenner, 2009, The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes, Proc Natl Acad Sci, 106, 17876, 10.1073/pnas.0909357106

A Kanhere, 2012, T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements, Nat Commun, 3, 1268, 10.1038/ncomms2260

Y Deng, 2004, Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly, J Immunol Baltim Md 1950, 172, 3437

YE Antebi, 2013, Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates, PLoS Biol, 11, e1001616, 10.1371/journal.pbio.1001616

SZ Ben-Sasson, 2000, Survival and cytokine polarization of naive CD4(+) T cells in vitro is largely dependent on exogenous cytokines, Eur J Immunol, 30, 1308, 10.1002/(SICI)1521-4141(200005)30:5<1308::AID-IMMU1308>3.0.CO;2-I

JW McAlees, 2015, Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma, Eur J Immunol, 45, 1019, 10.1002/eji.201444778

DJ Tumes, 2013, The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells, Immunity, 39, 819, 10.1016/j.immuni.2013.09.012

ZE Wang, 1994, CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major, J Exp Med, 179, 1367, 10.1084/jem.179.4.1367

L Cimmino, 2008, Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression, J Immunol Baltim Md 1950, 181, 2338

A Kelso, 1988, Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones, Proc Natl Acad Sci, 85, 9189, 10.1073/pnas.85.23.9189

M Löhning, 1999, T1/ST2 expression is enhanced on CD4+ T cells from schistosome egg-induced granulomas: analysis of Th cell cytokine coexpression ex vivo, J Immunol Baltim Md 1950, 162, 3882

P Openshaw, 1995, Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations, J Exp Med, 182, 1357, 10.1084/jem.182.5.1357

DM Yang, 1991, Identification and characterization of host-protective T-cell epitopes of a major surface glycoprotein (gp63) from Leishmania major, Immunology, 72, 3

A O’Garra, 2016, Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role, J Immunol, 196, 4423, 10.4049/jimmunol.1600646

W Lai, 2011, Transcriptional control of rapid recall by memory CD4 T cells, J Immunol Baltim Md 1950, 187, 133

J Zhu, 2012, The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, Immunity, 37, 660, 10.1016/j.immuni.2012.09.007