Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P 1 ′ group
Tài liệu tham khảo
Hendriks, 1989, J. Clin. Chem. Clin. Biochem., 27, 277
Campbell, 1989, Biochem. Biophys. Res. Commun., 162, 933, 10.1016/0006-291X(89)90762-6
Eaton, 1991, J. Biol. Chem., 266, 21833, 10.1016/S0021-9258(18)54713-X
Bajzar, 1995, J. Biol. Chem., 270, 14477, 10.1074/jbc.270.24.14477
Bouma, 2001, Thromb. Res., 101, 329, 10.1016/S0049-3848(00)00411-4
Bajzar, 2000, Arterioscler. Thromb. Vasc. Biol., 20, 2511, 10.1161/01.ATV.20.12.2511
Hoylaerts, 1982, J. Biol. Chem., 257, 2912, 10.1016/S0021-9258(19)81051-7
Horrevoets, 1997, J. Biol. Chem., 272, 2183, 10.1074/jbc.272.4.2183
Bajzar, 1996, J. Biol. Chem., 271, 16603, 10.1074/jbc.271.28.16603
Barrow, 2003, J. Med. Chem., 46, 5294, 10.1021/jm034141y
Also see: Allerton, C. M. N.; Blagg, J.; Bunnage, M. E. WO02/14285 A1 for a related series of TAFIa inhibitors
Mathews, 1980, Ann. Int. Med., 93, 443, 10.7326/0003-4819-93-3-443
Skidgel, 1996, Structure and function of mammalian zinc carboxypeptidases, 241
Aviles, 1993, Eur. J. Biochem., 211, 381, 10.1111/j.1432-1033.1993.tb17561.x
Vendrell, 2000, Biochem. Biophys. Acta, 1477, 284
Christianson, 1989, Acc. Chem. Res., 22, 62, 10.1021/ar00158a003
A full account of our studies regarding SAR studies in P1 is in preparation. Stauffer, S. R. et al.
For 8 see: Linschoten, M. et al. WO00/66557
Compound 9 was derived from methylation of the NHBoc intermediate
For 10 see: Sanderson, P. E.; Naylor-Olsen, A. M. US6093717
For 11 and 12 see: Askew, B. C. et al. US5852045
See: Belley, M. L. et al. US5428033