Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully

Xin Yu, 2019, The global pipeline of cell therapies for cancer, Nat. Rev. Drug Discov., 18, 821, 10.1038/d41573-019-00090-z Kudchadkar, 2020, Metastatic melanoma, CA Cancer J. Clin., 70, 78, 10.3322/caac.21599 Li, 2020, The nomogram model predicting overall survival and guiding clinical decision in patients with glioblastoma based on the SEER database, Front. Oncol., 10, 1051, 10.3389/fonc.2020.01051 Lu, 2020, Targeting the GRP78 pathway for cancer therapy, Front. Med., 7, 351, 10.3389/fmed.2020.00351 Weber, 2020, The emerging landscape of immune cell therapies, Cell, 181, 46, 10.1016/j.cell.2020.03.001 Rosenberg, 1986, A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes, Science, 233, 1318, 10.1126/science.3489291 Rosenberg, 1988, Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report, N. Engl. J. Med., 319, 1676, 10.1056/NEJM198812223192527 Eshhar, 1997, Tumor-specific T-bodies: towards clinical application, Cancer Immunol. Immunother., 45, 131, 10.1007/s002620050415 Tran, 2014, Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer, Science, 344, 641, 10.1126/science.1251102 Nguyen, 2019, Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2, Cancer Immunol. Immunother., 68, 773, 10.1007/s00262-019-02307-x Liu, 2018, Novel effector phenotype of Tim-3(+) regulatory T cells leads to enhanced suppressive function in head and neck cancer patients, Clin. Cancer Res., 24, 4529, 10.1158/1078-0432.CCR-17-1350 Zhang, 2019, Recharacterizing tumor-infiltrating lymphocytes by single-cell RNA sequencing, Cancer Immunol. Res., 7, 1040, 10.1158/2326-6066.CIR-18-0658 Stanton, 2016, Variation in the incidence and magnitude of tumor-infiltrating lymphocytes in breast cancer subtypes: a systematic review, JAMA Oncol., 2, 1354, 10.1001/jamaoncol.2016.1061 Becker, 1993, Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression, Clin. Exp. Immunol., 91, 121, 10.1111/j.1365-2249.1993.tb03365.x Dudley, 2003, Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients, J. Immunother., 26, 332, 10.1097/00002371-200307000-00005 Rosenberg, 2008, Adoptive cell transfer: a clinical path to effective cancer immunotherapy, Nat. Rev. Cancer, 8, 299, 10.1038/nrc2355 Aoki, 1991, Use of adoptive transfer of tumor-infiltrating lymphocytes alone or in combination with cisplatin-containing chemotherapy in patients with epithelial ovarian cancer, Cancer Res., 51, 1934 Hudson, 1998, Growth and antigen recognition of tumor-infiltrating lymphocytes from human breast cancer, J. Interferon Cytokine Res., 18, 529, 10.1089/jir.1998.18.529 Tang, 2019, The single-cell sequencing: new developments and medical applications, Cell Biosci., 9, 53, 10.1186/s13578-019-0314-y Crossey, 2018, Robust method for isolation of tumor infiltrating lymphocytes with a high vital cell yield from small samples of renal cell carcinomas by a new collagenase-free mechanical procedure, Urol. Oncol., 36, 402, 10.1016/j.urolonc.2018.06.002 Gros, 2014, PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors, J. Clin. Invest., 124, 2246, 10.1172/JCI73639 Robbins, 2013, Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells, Nat. Med., 19, 747, 10.1038/nm.3161 Swartz, 2018, A simple and enzyme-free method for processing infiltrating lymphocytes from small mouse tumors for ELISpot analysis, J. Immunol. Methods, 459, 90, 10.1016/j.jim.2018.05.015 Jin, 2012, Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment, J. Immunother., 35, 283, 10.1097/CJI.0b013e31824e801f Sakellariou-Thompson, 2019, Potential clinical application of tumor-infiltrating lymphocyte therapy for ovarian epithelial cancer prior or post-resistance to chemotherapy, Cancer Immunol. Immunother., 68, 1747, 10.1007/s00262-019-02402-z Poch, 2018, Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer, Oncoimmunology, 7, e1476816, 10.1080/2162402X.2018.1476816 Tavera, 2018, Utilizing T-cell activation signals 1, 2, and 3 for tumor-infiltrating lymphocytes (TIL) expansion: the advantage over the sole use of interleukin-2 in cutaneous and uveal melanoma, J. Immunother., 41, 399, 10.1097/CJI.0000000000000230 Richards, 2012, Flow cytometry assessment of residual melanoma cells in tumor-infiltrating lymphocyte cultures, Cytometry A, 81, 374, 10.1002/cyto.a.22047 Sapoznik, 2012, CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy, Cancer Immunol. Immunother., 61, 1833, 10.1007/s00262-012-1245-1 Wang, 2020, Th9 cells are subjected to PD-1/PD-L1-mediated inhibition and are capable of promoting CD8 T cell expansion through IL-9R in colorectal cancer, Int. Immunopharmacol., 78, 10.1016/j.intimp.2019.106019 Etxeberria, 2019, Intratumor adoptive transfer of IL-12 mRNA transiently engineered antitumor CD8(+) T cells, Cancer Cell, 36, 613, 10.1016/j.ccell.2019.10.006 Lu, 2018, An efficient single-cell RNA-Seq approach to identify neoantigen-specific T cell receptors, Mol. Ther., 26, 379, 10.1016/j.ymthe.2017.10.018 Gurusamy, 2020, Multi-phenotype CRISPR-Cas9 screen identifies p38 kinase as a target for adoptive immunotherapies, Cancer Cell, 37, 818, 10.1016/j.ccell.2020.05.004 Li, 2020, The transcription factor Bhlhe40 programs mitochondrial regulation of resident CD8(+) T cell fitness and functionality, Immunity, 52, 201, 10.1016/j.immuni.2019.12.008 Abe, 2020, Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer, Virchows Arch., 476, 701, 10.1007/s00428-019-02730-6 Truntzer, 2019, Prognostic value of transcriptomic determination of tumour-infiltrating lymphocytes in localised breast cancer, Eur. J. Cancer, 120, 97, 10.1016/j.ejca.2019.07.020 Forget, 2018, Prospective analysis of adoptive TIL therapy in patients with metastatic melanoma: response, impact of anti-CTLA4, and biomarkers to predict clinical outcome, Clin. Cancer Res., 24, 4416, 10.1158/1078-0432.CCR-17-3649 Besser, 2020, Comprehensive single institute experience with melanoma TIL: long term clinical results, toxicity profile, and prognostic factors of response, Mol. Carcinog., 59, 736, 10.1002/mc.23193 Mehta, 2018, Outcomes of adoptive cell transfer with tumor-infiltrating lymphocytes for metastatic melanoma patients with and without brain metastases, J. Immunother., 41, 241, 10.1097/CJI.0000000000000223 Smyth, 2016, Combination cancer immunotherapies tailored to the tumour microenvironment, Nat. Rev. Clin. Oncol., 13, 143, 10.1038/nrclinonc.2015.209 Noh, 2020, Immune classification for the PD-L1 expression and tumour-infiltrating lymphocytes in colorectal adenocarcinoma, BMC Cancer, 20, 58, 10.1186/s12885-020-6553-9 Yagi, 2019, PD-L1 expression, tumor-infiltrating lymphocytes, and clinical outcome in patients with surgically resected esophageal cancer, Ann. Surg., 269, 471, 10.1097/SLA.0000000000002616 Parkhurst, 2019, Unique neoantigens arise from somatic mutations in patients with gastrointestinal cancers, Cancer Discov., 9, 1022, 10.1158/2159-8290.CD-18-1494 Tran, 2016, T-Cell transfer therapy targeting mutant KRAS in cancer, N. Engl. J. Med., 375, 2255, 10.1056/NEJMoa1609279 Edin, 2019, The prognostic importance of CD20(+) B lymphocytes in colorectal cancer and the relation to other immune cell subsets, Sci. Rep., 9, 19997, 10.1038/s41598-019-56441-8 Rozek, 2016, Tumor-infiltrating lymphocytes, Crohn’s-like lymphoid reaction, and survival from colorectal cancer, J. Natl. Cancer Inst., 108, 10.1093/jnci/djw027 Cai, 2006, Dendritic cell infiltration and prognosis of human hepatocellular carcinoma, J. Cancer Res. Clin. Oncol., 132, 293, 10.1007/s00432-006-0075-y Tanaka, 2020, Preoperative neutrophil-to-lymphocyte ratio predicts tumor-infiltrating CD8(+) T cells in biliary tract cancer, Anticancer Res., 40, 2881, 10.21873/anticanres.14264 Choe, 2019, Dynamic changes in PD-L1 expression and CD8(+) T cell infiltration in non-small cell lung cancer following chemoradiation therapy, Lung Cancer, 136, 30, 10.1016/j.lungcan.2019.07.027 Zhu, 2019, Transcriptome analysis reveals an important candidate gene involved in both nodal metastasis and prognosis in lung adenocarcinoma, Cell Biosci., 9, 92, 10.1186/s13578-019-0356-1 Zhu, 2012, An intronic polymorphism in GRP78 improves chemotherapeutic prediction in non-small cell lung cancer, Chest, 141, 1466, 10.1378/chest.11-0469 Tan, 2020, Cancer immunotherapy: pros, cons and beyond, Biomed. Pharmacother., 124, 10.1016/j.biopha.2020.109821 Li, 2020, How to overcome the side effects of tumor immunotherapy, Biomed. Pharmacother., 130, 10.1016/j.biopha.2020.110639 Tancos, 2020, Programmed death-ligand 1 expression in non-small cell lung carcinoma biopsies and its association with tumor infiltrating lymphocytes and the degree of desmoplasia, Klin. Onkol., 33, 55, 10.14735/amko202055 Yoneda, 2019, Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer, Br. J. Cancer, 121, 490, 10.1038/s41416-019-0541-3 Zhang, 2010, Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways, Mol. Cancer, 9, 4, 10.1186/1476-4598-9-4 Ono, 2018, Prognostic stratification of patients with nasopharyngeal carcinoma based on tumor immune microenvironment, Head Neck, 40, 2007, 10.1002/hed.25189 Thike, 2020, Higher densities of tumour-infiltrating lymphocytes and CD4(+) T cells predict recurrence and progression of ductal carcinoma in situ of the breast, Histopathology, 76, 852, 10.1111/his.14055 Zou, 2020, mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges, Cell Biosci., 10, 31, 10.1186/s13578-020-00396-1 Li, 2020, Microsatellite instability: a review of what the oncologist should know, Cancer Cell Int., 20, 16, 10.1186/s12935-019-1091-8 Liang, 2020, GWAS in cancer: progress and challenges, Mol. Genet. Genom., 295, 537, 10.1007/s00438-020-01647-z Li, 2020, Three-dimensional genome: developmental technologies and applications in precision medicine, J. Hum. Genet., 65, 497, 10.1038/s10038-020-0737-7 Zacharakis, 2018, Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer, Nat. Med., 24, 724, 10.1038/s41591-018-0040-8 Loi, 2013, Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98, J. Clin. Oncol., 31, 860, 10.1200/JCO.2011.41.0902 Baker, 2011, Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade, Histopathology, 58, 1107 Syed Khaja, 2017, Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment, Oncotarget, 8, 33159, 10.18632/oncotarget.16565 Klingen, 2017, Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer, Hum. Pathol., 69, 72, 10.1016/j.humpath.2017.09.001 Toss, 2018, Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast, Mod. Pathol., 31, 1226, 10.1038/s41379-018-0040-8 Kovacs, 2019, Effect of radiotherapy after breast-conserving surgery depending on the presence of tumor-infiltrating lymphocytes: a long-term follow-up of the SweBCG91RT randomized trial, J. Clin. Oncol., 37, 1179, 10.1200/JCO.18.02157 Denkert, 2018, Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy, Lancet Oncol., 19, 40, 10.1016/S1470-2045(17)30904-X Gao, 2020, Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis, BMC Cancer, 20, 179, 10.1186/s12885-020-6668-z Blok, 2018, Exploration of tumour-infiltrating lymphocytes as a predictive biomarker for adjuvant endocrine therapy in early breast cancer, Breast Cancer Res. Treat., 171, 65, 10.1007/s10549-018-4785-z Ingold Heppner, 2016, Tumor-infiltrating lymphocytes: a predictive and prognostic biomarker in neoadjuvant-treated HER2-positive breast cancer, Clin. Cancer Res., 22, 5747, 10.1158/1078-0432.CCR-15-2338 Hida, 2019, Diffuse distribution of tumor-infiltrating lymphocytes is a marker for better prognosis and chemotherapeutic effect in triple-negative breast cancer, Breast Cancer Res. Treat., 178, 283, 10.1007/s10549-019-05390-x Takada, 2018, Significance of re-biopsy for recurrent breast cancer in the immune tumour microenvironment, Br. J. Cancer, 119, 572, 10.1038/s41416-018-0197-4 West, 2011, Intratumoral immune responses can distinguish new primary and true recurrence types of ipsilateral breast tumor recurrences (IBTR), Breast Cancer (Auckl), 5, 105 Liang, 2020, A prognostic model guides surgical resection in cervical squamous cell carcinoma, Transl. Cancer Res., 9, 1711, 10.21037/tcr.2020.02.71 Stevanovic, 2019, A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers, Clin. Cancer Res., 25, 1486, 10.1158/1078-0432.CCR-18-2722 Oberg, 2020, Bispecific antibodies enhance tumor-infiltrating T cell cytotoxicity against autologous HER-2-expressing high-grade ovarian tumors, J. Leukoc. Biol., 107, 1081, 10.1002/JLB.5MA1119-265R Tang, 2020, The cancer exosomes: clinical implications, applications and challenges, Int. J. Cancer, 146, 2946, 10.1002/ijc.32762 Guo, 2020, piRNAs: biogenesis and their potential roles in cancer, Cancer Metastasis Rev., 39, 567, 10.1007/s10555-020-09863-0 Liu, 2019, Circular RNAs: the star molecules in cancer, Mol. Asp. Med., 70, 141, 10.1016/j.mam.2019.10.006 Ovarian Tumor Tissue Analysis, 2017, Dose-response association of CD8+ tumor-infiltrating lymphocytes and survival time in high-grade serous ovarian cancer, JAMA Oncol., 3 Huang, 2019, Clinical significance of tumor infiltrating lymphocytes in high-grade serous ovarian carcinoma, Zhonghua Bing Li Xue Za Zhi, 48, 610 Nielsen, 2012, CD20+ tumor-infiltrating lymphocytes have an atypical CD27- memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer, Clin. Cancer Res., 18, 3281, 10.1158/1078-0432.CCR-12-0234 Nguyen, 2016, Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma, Head Neck, 38, 1074, 10.1002/hed.24406 Hartman, 2019, Corrigendum to “Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma” [Oral Oncol. 86 (2018) 278-287], Oral Oncol., 93, 129, 10.1016/j.oraloncology.2019.04.016 Xiao, 2019, CD103(+) T and dendritic cells indicate a favorable prognosis in oral cancer, J. Dent. Res., 98, 1480, 10.1177/0022034519882618 Stravodimou, 2018, Evaluation of T-lymphocyte subpopulations in actinic keratosis, in situ and invasive squamous cell carcinoma of the skin, J. Cutan. Pathol., 45, 337, 10.1111/cup.13123 Ricci, 2020, Prognostic impact of MCPyV and TIL subtyping in Merkel cell carcinoma: evidence from a Large European Cohort of 95 Patients, Endocr. Pathol., 31, 21, 10.1007/s12022-019-09601-5 Al-Rajhi, 2020, CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma, BMC Cancer, 20, 240, 10.1186/s12885-020-06757-w Zhou, 2019, Clinicopathological implications of TIM3(+) tumor-infiltrating lymphocytes and the miR-455-5p/Galectin-9 axis in skull base chordoma patients, Cancer Immunol. Immunother., 68, 1157, 10.1007/s00262-019-02349-1 Xu, 2020, Cancer neoantigen: boosting immunotherapy, Biomed. Pharmacother., 131, 10.1016/j.biopha.2020.110640 Xiao, 2020, The associations of hub gene polymorphisms in PI3K/AKT/mTOR pathway and Schistosomiasis Japonica infection and hepatic fibrosis, Infect. Genet. Evol., 85, 10.1016/j.meegid.2020.104423 Sasada, 2020, Tumor-infiltrating lymphocyte score based on FDG PET/CT for predicting the effect of neoadjuvant chemotherapy in breast cancer, Anticancer Res., 40, 3395, 10.21873/anticanres.14323 Keren, 2018, A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging, Cell, 174, 1373, 10.1016/j.cell.2018.08.039