Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth

Developmental Cell - Tập 39 Số 4 - Trang 466-479 - 2016
Zhiqiang Lin1, Hai-dong Guo2,1, Yuan Cao1,3, Sylvia Zohrabian1, Pingzhu Zhou1, Qing Ma1, Nathan J. VanDusen1, Yuxuan Guo1, Jin Zhang1, Sean M. Stevens1, Feng Liang4, Qimin Quan4, Pim R. van Gorp5, Amy Li6, Cristobal G. dos Remedios6, Aibin He7, Vassilios J. Bezzerides1, William T. Pu1,8
1Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
2Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
3Peking University Fifth School of Clinical Medicine, Beijing, 100730, China
4Rowland Institute at Harvard, Harvard University, Cambridge, MA 02142, USA
5Department of Cardiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.
6Department of Anatomy & Histology, Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia
7Institute of Molecular Medicine, Peking University, PKU-Tsinghua U Joint Center for Life Sciences, Beijing 100871, China
8Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bai, 2012, Yes-associated protein regulates the hepatic response after bile duct ligation, Hepatology, 56, 1097, 10.1002/hep.25769

Barrett, 1982, L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L, Biochem. J., 201, 189, 10.1042/bj2010189

Camargo, 2007, YAP1 increases organ size and expands undifferentiated progenitor cells, Curr. Biol., 17, 2054, 10.1016/j.cub.2007.10.039

Chan, 2001, p300/CBP proteins: HATs for transcriptional bridges and scaffolds, J. Cell Sci., 114, 2363, 10.1242/jcs.114.13.2363

Chen, 2004, Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes, J. Biol. Chem., 279, 30800, 10.1074/jbc.M400154200

de Boer, 2003, Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice, Proc. Natl. Acad. Sci. USA, 100, 7480, 10.1073/pnas.1332608100

Del Re, 2013, Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury, J. Biol. Chem., 288, 3977, 10.1074/jbc.M112.436311

Dong, 2007, Elucidation of a universal size-control mechanism in Drosophila and mammals, Cell, 130, 1120, 10.1016/j.cell.2007.07.019

Dupont, 2011, Role of YAP/TAZ in mechanotransduction, Nature, 474, 179, 10.1038/nature10137

Galli, 2015, YAP drives growth by controlling transcriptional pause release from dynamic enhancers, Mol. Cell, 60, 328, 10.1016/j.molcel.2015.09.001

Hata, 2012, A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents, J. Biol. Chem., 287, 22089, 10.1074/jbc.M111.334714

He, 2012, PRC2 directly methylates GATA4 and represses its transcriptional activity, Genes Dev., 26, 37, 10.1101/gad.173930.111

Heallen, 2011, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size, Science, 332, 458, 10.1126/science.1199010

Heallen, 2013, Hippo signaling impedes adult heart regeneration, Development, 140, 4683, 10.1242/dev.102798

Heidenreich, 2013, Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association, Circ. Heart Fail., 6, 606, 10.1161/HHF.0b013e318291329a

Huang, 2005, The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP, Cell, 122, 421, 10.1016/j.cell.2005.06.007

Jiao, 2014, A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer, Cancer Cell, 25, 166, 10.1016/j.ccr.2014.01.010

Kajstura, 1998, Myocyte proliferation in end-stage cardiac failure in humans, Proc. Natl. Acad. Sci. USA, 95, 8801, 10.1073/pnas.95.15.8801

Koontz, 2013, The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression, Dev. Cell, 25, 388, 10.1016/j.devcel.2013.04.021

Lee, 1998, The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression, Mol. Cell Biol., 18, 3120, 10.1128/MCB.18.6.3120

Li, 2014, Alpha-catenins control cardiomyocyte proliferation by regulating yap activity, Circ. Res., 116, 70, 10.1161/CIRCRESAHA.116.304472

Lin, 2014, Strategies for cardiac regeneration and repair, Sci. Transl. Med., 6, 239rv1, 10.1126/scitranslmed.3006681

Lin, 2015, Releasing YAP from an α-catenin trap increases cardiomyocyte proliferation, Circ. Res., 116, 9, 10.1161/CIRCRESAHA.114.305496

Lin, 2014, Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model, Circ. Res., 115, 354, 10.1161/CIRCRESAHA.115.303632

Nakayama, 2007, Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure, J. Clin. Invest., 117, 2431, 10.1172/JCI31060

Oudhoff, 2013, Control of the hippo pathway by Set7-dependent methylation of Yap, Dev. Cell, 26, 188, 10.1016/j.devcel.2013.05.025

Pan, 2010, The hippo signaling pathway in development and cancer, Dev. Cell, 19, 491, 10.1016/j.devcel.2010.09.011

Prasad, 2011, Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution, Gene Ther., 18, 43, 10.1038/gt.2010.105

Schlegelmilch, 2011, Yap1 acts downstream of alpha-catenin to control epidermal proliferation, Cell, 144, 782, 10.1016/j.cell.2011.02.031

Snippert, 2010, Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells, Cell, 143, 134, 10.1016/j.cell.2010.09.016

Söderberg, 2006, Direct observation of individual endogenous protein complexes in situ by proximity ligation, Nat. Methods, 3, 995, 10.1038/nmeth947

Umezawa, 1976, Structures and activities of protease inhibitors of microbial origin, Methods Enzymol., 45, 678, 10.1016/S0076-6879(76)45058-9

Varelas, 2010, The Hippo pathway regulates Wnt/beta-catenin signaling, Dev. Cell, 18, 579, 10.1016/j.devcel.2010.03.007

von Gise, 2012, YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy, Proc. Natl. Acad. Sci. USA, 109, 2394, 10.1073/pnas.1116136109

Walsh, 2010, Cardiomyocyte cell cycle control and growth estimation in vivo—an analysis based on cardiomyocyte nuclei, Cardiovasc. Res., 86, 365, 10.1093/cvr/cvq005

Xin, 2011, Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size, Sci. Signal., 4, ra70, 10.1126/scisignal.2002278

Xin, 2013, Hippo pathway effector Yap promotes cardiac regeneration, Proc. Natl. Acad. Sci. USA, 110, 13839, 10.1073/pnas.1313192110

Yang, 2014, High sensitivity and high Q-factor nanoslotted parallel quadrabeam photonic crystal cavity for real-time and label-free sensing, Appl. Phys. Lett., 105, 063118, 10.1063/1.4867254

Yoshida, 2008, MCAT elements and the TEF-1 family of transcription factors in muscle development and disease, Arterioscler. Thromb. Vasc. Biol., 28, 8, 10.1161/ATVBAHA.107.155788

Zanconato, 2015, Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth, Nat. Cell Biol., 17, 1218, 10.1038/ncb3216

Zhang, 2007, Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions, Genome Res., 17, 787, 10.1101/gr.5573107

Zhang, 2014, Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion, J. Biol. Chem., 289, 18681, 10.1074/jbc.M114.554584