Studies of a DNA marker (G8) genetically linked to Huntington disease in British families

Springer Science and Business Media LLC - Tập 73 - Trang 333-339 - 1986
Sandra Youngman1, M. Sarfarazi1, O. W. J. Quarrell1, P. M. Conneally2, Karen Gibbons3, P. S. Harper1, D. J. Shaw1, R. E. Tanzi3, Margaret R. Wallace2, J. F. Gusella3
1Section of Medical Genetics, University of Wales College of Medicine, Cardiff, UK
2Department of Medical Genetics, Indiana University Medical Center, Indianapolis, USA
3Massachusetts General Hospital, Boston, USA

Tóm tắt

Close genetic linkage has been shown between the DNA sequence G8 (locus D4S10) and 16 British families with Huntington disease using the HindIII, EcoR1, Nci1, and Pst1 polymorphisms detected by G8, and by combining all the polymorphisms to give a combined haplotype. Two recombinants have been detected in these families giving a maximum lod score of 17.60 at a Θ of 0.02. These results confirm the originally reported linkage between the loci and provide evidence against significant multilocus heterogeneity for Huntington disease.

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Springer Science and Business Media LLC

Tập 73

333-339

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