A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose–response and low dose effects on rat brain aromatase activity
Tài liệu tham khảo
Amateau, 2004, Brain estradiol content in newborn rats: sex differences, regional heterogeneity, and possible de novo synthesis by the female telencephalon, Endocrinology, 145, 2906, 10.1210/en.2003-1363
Andrade, 2006, A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate: effects on androgenic status, developmental landmarks and testicular histology in male offspring rats, Toxicology, 225, 64, 10.1016/j.tox.2006.05.007
Agency for Toxic Substances Disease Registry (ATSDR), 2002
Blount, 2000, Levels of seven urinary phthalate metabolites in a human reference population, Environ. Health Perspect., 108, 979, 10.1289/ehp.00108979
Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3
Calabrese, 2003, Hormesis: the dose–response revolution, Annu. Rev. Pharmacol. Toxicol., 43, 175, 10.1146/annurev.pharmtox.43.100901.140223
Conolly, 2004, Non-monotonic dose–response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment, Toxicol. Sci., 77, 151, 10.1093/toxsci/kfh007
Davis, 1994, Mono-(2-ethylhexyl)-phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells, Toxicol. Appl. Pharmacol., 128, 224, 10.1006/taap.1994.1201
Eaton, 1996, Principles of toxicology, 13
Faustman, 1996, Risk assessment, 75
Fisher, 2003, Human ‘testicular dysgenesis syndrome’: a possible model using in utero exposure of the rat to dibutyl phthalate, Hum. Reprod., 18, 1383, 10.1093/humrep/deg273
George, 1982, Changes in aromatase activity in the rat brain during embryonic, neonatal, and infantile development, Endocrinology, 111, 522, 10.1210/endo-111-2-522
Gorski, 1986, Sexual differentiation of the brain: a model for drug-induced alterations of the reproductive system, Environ. Health Perspect., 70, 163, 10.1289/ehp.8670163
Grande, 2006, A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate: effects on female rat reproductive development, Toxicol. Sci., 91, 247, 10.1093/toxsci/kfj128
Gray, 2000, Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat, Toxicol. Sci., 58, 350, 10.1093/toxsci/58.2.350
Grote, 2006, Effects of peripubertal exposure to triphenyltin on female sexual development of the rat, Toxicology, 222, 17, 10.1016/j.tox.2006.01.008
Hany, 1999, Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior, Toxicol. Appl. Pharmacol., 158, 231, 10.1006/taap.1999.8710
Koch, 2003, An estimation of the daily intake of di-(2-ethylhexyl)-phthalate (DEHP) and other phthalates in the general population, Int. J. Hyg. Environ. Health, 206, 77, 10.1078/1438-4639-00205
Koch, 2006, Di-(2-ethylhexyl)-phthalate (DEHP): human metabolism and internal exposure—an update and latest results, Int. J. Androl., 29, 155, 10.1111/j.1365-2605.2005.00607.x
Lauber, 1997, Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain, J. Steroid Biochem. Mol. Biol., 61, 359, 10.1016/S0960-0760(97)80033-7
Lephart, 1992, Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat, Brain Res. Mol. Brain Res., 16, 187, 10.1016/0169-328X(92)90224-Y
Lephart, 1996, A review of brain aromatase cytochrome P450, Brain Res. Brain Res. Rev., 22, 1, 10.1016/0165-0173(96)00002-1
Lovekamp, 2001, Mono-(2-ethylhexyl)-phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells, Toxicol. Appl. Pharmacol., 172, 217, 10.1006/taap.2001.9156
Lovekamp-Swan, 2003, Mechanisms of phthalate ester toxicity in the female reproductive system, Environ. Health Perspect., 111, 139, 10.1289/ehp.5658
Moore, 2001, Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer di-(2-ethylhexyl)-phthalate, Environ. Health Perspect., 109, 229, 10.1289/ehp.01109229
Mylchreest, 1999, Disruption of androgen-regulated male reproductive development by di-(n-butyl)-phthalate during late gestation in rats is different from flutamide, Toxicol. Appl. Pharmacol., 156, 81, 10.1006/taap.1999.8643
Mylchreest, 2002, Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di-(n-butyl)-phthalate, Reprod. Toxicol., 16, 19, 10.1016/S0890-6238(01)00201-5
Parks, 2000, The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat, Toxicol. Sci., 58, 339, 10.1093/toxsci/58.2.339
Roselli, 1995, Subcellular localization and kinetic properties of aromatase activity in rat brain, J. Steroid Biochem. Mol. Biol., 52, 469, 10.1016/0960-0760(94)00192-O
Roselli, 1997, Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain, J. Steroid Biochem. Mol. Biol., 61, 365, 10.1016/S0960-0760(97)80034-9
Roselli, 1998, Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure, Endocrinology, 139, 3193, 10.1210/en.139.7.3193
Roselli, 2003, Role of aromatization in anticipatory and consummatory aspects of sexual behavior in male rats, Horm. Behav., 44, 146, 10.1016/S0018-506X(03)00123-5
SCMPMD, European Union Scientific Committee on Medicinal Products and Medical Devices, 2002. Opinion on medical devices containing DEHP plasticised PVC. Neonates and other groups possibly at risk from DEHP toxicity. Doc.SANCO/SCMPMD/2002/0010 Final. European Commission, Brussels.
Sharpe, 2001, Hormones and testis development and the possible adverse effects of environmental chemicals, Toxicol. Lett., 120, 221, 10.1016/S0378-4274(01)00298-3
Sharpe, 2006, Pathways of endocrine disruption during male sexual differentiation and masculinization, Best Pract. Res. Clin. Endocrinol. Metab., 20, 91, 10.1016/j.beem.2005.09.005
Silva, 2004, Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000, Environ. Health Perspect., 112, 331, 10.1289/ehp.6723
Swan, 2005, Decrease in anogenital distance among male infants with prenatal phthalate exposure, Environ. Health Perspect., 113, 1056, 10.1289/ehp.8100
Tian, 2004, Decreased hypothalamic aromatization in female rats of true precocious puberty, Neurosci. Lett., 366, 92, 10.1016/j.neulet.2004.05.012
Tierschutzgesetz BGBI. I S. 1105, 1998.
vom Saal, 1997, Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses, Proc. Natl. Acad. Sci., 94, 2056, 10.1073/pnas.94.5.2056
Welshons, 2003, Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity, Environ. Health Perspect., 111, 994, 10.1289/ehp.5494
Zenick, 1989, Assessment of male reproductive toxicity: a risk assessment approach, 275
