Modeling Plasma Virus Concentration during Primary HIV Infection

Journal of Theoretical Biology - Tập 203 - Trang 285-301 - 2000
MAX A. STAFFORD1,2, LAWRENCE COREY3, YUNZHEN CAO4, ERIC S. DAAR5, DAVID D. HO4, ALAN S. PERELSON6
1Computing and Mathematical Sciences Department, Texas A & M University-Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX, 78412, U.S.A.
2Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM 87501, U.S.A.
3Hutchison Cancer Research Center, Program in Infectious Disease, 1100 Fairview Avenue North, Seattle, WA, 98109, U.S.A.
4Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY, 10016, U.S.A.
5Cedars-Sinai Medical Center, Division of Infectious Diseases, Los Angeles, CA, 90048, U.S.A.
6Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, U.S.A.

Tài liệu tham khảo

BONHOEFFER, 1997, Virus dynamics and drug therapy, Proc. Nat. Acad. Sci. U.S.A., 94, 6971, 10.1073/pnas.94.13.6971 BORROW, 1997, Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus, Nat. Med., 3, 205, 10.1038/nm0297-205 CLARK, 1991, High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection, New Engl. J. Med., 324, 954, 10.1056/NEJM199104043241404 COLLINS, 1998, HIV-1 nef protein protects infected primary cells against killing by cytotoxic T lymphocytes, Nature, 391, 397, 10.1038/34929 DAAR, 1991, Transient high levels of viremia in patients with primary human immunodeficiency virus type 1, New Engl. J. Med., 324, 961, 10.1056/NEJM199104043241405 D'ARGENIO, 1997 DEBOER, 1998, Target cell limited and immune control models of HIV infection: a comparison, J. theor. Biol., 190, 201, 10.1006/jtbi.1997.0548 ESSUNGER, 1994, Modeling HIV infection of CD4+ T-cell subpopulations, J. theor. Biol., 170, 367, 10.1006/jtbi.1994.1199 GUIDOTTI, 1999, Viral clearance without destruction of infected cells during acute HBV infection, Science, 284, 825, 10.1126/science.284.5415.825 HAASE, 1999, Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues, Ann. Rev. Immunol., 17, 625, 10.1146/annurev.immunol.17.1.625 HO, 1995, Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection, Nature, 373, 123, 10.1038/373123a0 HRABA, 1990, Model-based analysis of CD4+ lymphocyte dynamics in HIV infected individuals, Immunobiology, 181, 108, 10.1016/S0171-2985(11)80169-5 JIN, 1999, Dramatic rise in plasma viremia after CD8+ T-cell depletion in SIV-infected macaques, J. Exp. Med., 189, 991, 10.1084/jem.189.6.991 KAHN, 1998, Acute human immunodeficiency virus type 1 infection, New Engl. J. Med., 339, 33, 10.1056/NEJM199807023390107 KAUFMANN, 1998, Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection, J. Infec. Dis., 178, 1812, 10.1086/314480 KIRSCHNER, 1998, Role of the thymus in pediatric HIV-1 infection, J. AIDS Human Retrovirol., 18, 95 KLENERMAN, 1996, Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection, Proc. Nat. Acad. Sci. U.S.A., 93, 15323, 10.1073/pnas.93.26.15323 KOUP, 1994, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome, J. Virol., 68, 4650, 10.1128/JVI.68.7.4650-4655.1994 LITTLE, 1999, Viral dynamics of acute HIV-1 infection, J. Exp. Med., 190, 141, 10.1084/jem.190.6.841 MACIASZEK, 1997, IL-16 represses HIV-1 promoter activity, J. Immunol., 158, 5, 10.4049/jimmunol.158.1.5 MACKEWICZ, 1995, CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription, Proc. Nat. Acad. Sci. U.S.A., 92, 2231, 10.1073/pnas.92.6.2308 MATANO, 1998, Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques, J. Virol., 72, 164, 10.1128/JVI.72.1.164-169.1998 MCLEAN, 1991, Population dynamics of HIV within an individual after treatment with zidovudine, AIDS, 5, 485, 10.1097/00002030-199105000-00002 MCLEAN, 1990, A model of human immunodeficiency virus infection in T helper cell clones, J. theor. Biol., 147, 177, 10.1016/S0022-5193(05)80051-7 MCLEAN, 1992, Models of interactions between HIV and other pathogens, J. theor. Biol., 155, 69, 10.1016/S0022-5193(05)80549-1 MERRILL, 1989, Modeling the interaction of HIV with cells of the immune response, 83, 371 MITTLER, 1999, Improved estimates for HIV-1 clearance rate and intracellular delay, AIDS, 13, 1415, 10.1097/00002030-199907300-00023 MURRAY, 1998, A model of primary HIV-1 infection, Math. Biosci., 154, 57, 10.1016/S0025-5564(98)10046-9 MUSEY, 1998, Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type I infection, New Engl. J. Med., 337, 1267, 10.1056/NEJM199710303371803 NOWAK, 1990, The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease, AIDS, 4, 1095, 10.1097/00002030-199011000-00007 NOWAK, 1991, Antigenic diversity thresholds and the development of AIDS, Science, 254, 963, 10.1126/science.1683006 NOWAK, 1996, Population dynamics of immune responses to persistent viruses, Science, 272, 74, 10.1126/science.272.5258.74 NOWAK, 1997, Viral dynamics in primary viremia and anti-retroviral therapy in simian immunodeficiency virus infection, J. Virol., 71, 7518, 10.1128/JVI.71.10.7518-7525.1997 NOWAK, 1997, Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations, J. theor. Biol., 184, 203, 10.1006/jtbi.1996.0307 OGG, 1998, Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA, Science, 279, 2103, 10.1126/science.279.5359.2103 PANTALEO, 1997, The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia, Proc. Nat. Acad. Sci. U.S.A., 94, 254, 10.1073/pnas.94.1.254 PERELSON, 1989, Modeling the interaction of the immune system with HIV, 83, 350 PERELSON, 1993, Dynamics of HIV infection of CD4+ T cells, Math. Biosci., 114, 81, 10.1016/0025-5564(93)90043-A PERELSON, 1999, Mathematical analysis of HIV-1 dynamics in vivo, SIAM Rev., 41, 3, 10.1137/S0036144598335107 PERELSON, 1996, HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time, Science, 271, 1582, 10.1126/science.271.5255.1582 PHILLIPS, 1996, Reduction of HIV concentration during acute infection: independence from a specific immune response, Science, 271, 497, 10.1126/science.271.5248.497 RAMRATNAM, 1999, Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis, Lancet, 354, 1782, 10.1016/S0140-6736(99)02035-8 REIBNEGGER, 1989, Stability analysis of simple models for immune cells interacting with normal pathogens and immune system retroviruses, Proc. Nat. Acad. Sci. U.S.A., 86, 2030, 10.1073/pnas.86.6.2026 RINALDO, 1995, High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors, J. Virol., 69, 5838, 10.1128/JVI.69.9.5838-5842.1995 RIVIERE, 1995, Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS, AIDS Res. Human Retroviruses, 11, 903, 10.1089/aid.1995.11.903 SACHSENBERG, 1998, Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 infection as measured by Ki-67 antigen, J. Exp. Med., 187, 1295, 10.1084/jem.187.8.1295 SCHACKER, 1996, Clinical and epidemiologic features of primary HIV infection, Ann. Int. Med., 125, 257, 10.7326/0003-4819-125-4-199608150-00001 SCHENZLE, 1994, A model for AIDS pathogenesis, Statist. Med., 13, 2067, 10.1002/sim.4780131916 SCHMITZ, 1999, Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes, Science, 283, 857, 10.1126/science.283.5403.857 SCHNITTMAN, 1990, Preferential infection of CD4+ memory T cells by human immunodeficiency virus type-1: evidence for a role in the selective T-cell functional defects observed in infected individuals, Proc. Nat. Acad. Sci. U.S.A., 87, 6052, 10.1073/pnas.87.16.6058 STEVENSON, 1990, HIV-1 replication is controlled at the level of T cell activation and proviral integration, EMBO J., 9, 1551, 10.1002/j.1460-2075.1990.tb08274.x STILIANAKIS, 1997, Analysis of a model for the pathogenesis of AIDS, Math. Biosci., 145, 27, 10.1016/S0025-5564(97)00018-7 WALKER, 1986, CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication, Science, 234, 1563, 10.1126/science.2431484 WEI, 1995, Viral dynamics in human immunodeficiency virus type 1 infection, Nature, 373, 117, 10.1038/373117a0 WU, 1999, Characterization of viral dynamics in human immunodeficiency virus type-1 infected patients treated with combination antiretroviral therapy; relationships to host factors, cellular restoration, and virologic end points, J. Infect. Dis., 179, 799, 10.1086/314670 ZACK, 1992, Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle, J. Virol., 66, 1717, 10.1128/JVI.66.3.1717-1725.1992 ZHANG, 1999, Sexual transmission and propagation of SIV and HIV in resting and activated CD4+T cells, Science, 286, 1353, 10.1126/science.286.5443.1353