Studies on the calcium antagonistic action of tetrandrine: XIV. Influence of tetrandrine and verapamil on hemodynamic action of ouabain in guinea pig
Tóm tắt
After pretreatment with verapamil (Ver) and tetrandrine (Tet), the amount of ouabain required to induce the onset and peaking of inotropic effect as well as toxic reaction was increased, while peak value of positive inotropic effect was unaltered. Neither the toxicity of ouabain nor its margin of safety was changed, but preventive and therapeutic action of Tet and Ver on ouabain-induced arrhythmia were demonstrated. The anti-arrhythmic effects of tetrandrine, like Ver, may be relevant to Ca-antagonistic action.
Tài liệu tham khảo
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