Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Nature - Tập 558 Số 7708 - Trang 136-140 - 2018
Álvaro F. Fernández1, Salwa Sebti1, Yongjie Wei1, Zhongju Zou1, Mingjun Shi2, Kathryn L. McMillan2, Congcong He3, Tabitha C. Ting4, Yang Liu1, Wei‐Chung Chiang1, Denise K. Marciano4, Gabriele G. Schiattarella4, Govind Bhagat5, Orson W. Moe4, Ming Chang Hu4, Beth Levine6
1Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
2Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
3Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
4Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
5Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA
6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA

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