Immune regulation by novel costimulatory molecules

Springer Science and Business Media LLC - Tập 28 - Trang 39-48 - 2003
Chen Dong1, Roza I. Nurieva1, Durbaka V. R. Prasad1
1Department of Immunology, University of Washington School of Medicine, Seattle

Tóm tắt

CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

Tài liệu tham khảo

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