Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Agani, 2000, The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia, J. Biol. Chem., 275, 35863, 10.1074/jbc.M005643200 Au, 1999, The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria, Proc. Natl. Acad. Sci. USA, 96, 4354, 10.1073/pnas.96.8.4354 BelAiba, 2004, Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells, Biol. Chem., 385, 249, 10.1515/BC.2004.019 Bruick, 2001, A conserved family of prolyl-4-hydroxylases that modify HIF, Science, 294, 1337, 10.1126/science.1066373 Chandel, 1995, Inhibition of cytochrome-c oxidase activity during prolonged hypoxia, Am. J. Physiol., 268, L918 Chandel, 1998, Mitochondrial reactive oxygen species trigger hypoxia-induced transcription, Proc. Natl. Acad. Sci. USA, 95, 11715, 10.1073/pnas.95.20.11715 Chandel, 2000, Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing, J. Biol. Chem., 275, 25130, 10.1074/jbc.M001914200 Dagsgaard, 2001, Effects of anoxia and the mitochondrion on expression of aerobic nuclear COX genes in yeast: evidence for a signaling pathway from the mitochondrial genome to the nucleus, J. Biol. Chem., 276, 7593, 10.1074/jbc.M009180200 Enomoto, 2002, Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells, Biochem. Biophys. Res. Commun., 297, 346, 10.1016/S0006-291X(02)02186-1 Epstein, 2001, C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, 107, 43, 10.1016/S0092-8674(01)00507-4 Gerald, 2004, JunD reduces tumor angiogenesis by protecting cells from oxidative stress, Cell, 118, 781, 10.1016/j.cell.2004.08.025 Goyal, 2004, Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species, Free Radic. Biol. Med., 36, 1279, 10.1016/j.freeradbiomed.2004.02.071 Hagen, 2003, Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha, Science, 302, 1975, 10.1126/science.1088805 Hirsila, 2003, Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor, J. Biol. Chem., 278, 30772, 10.1074/jbc.M304982200 Ivan, 2001, HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, 292, 464, 10.1126/science.1059817 Jaakkola, 2001, Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796 Jiang, 1996, Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension, Am. J. Physiol., 271, C1172, 10.1152/ajpcell.1996.271.4.C1172 Kaelin, 2002, How oxygen makes its presence felt, Genes Dev., 16, 1441, 10.1101/gad.1003602 Moeller, 2004, Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules, Cancer Cell, 5, 429, 10.1016/S1535-6108(04)00115-1 Pfaffl, 2001, A new mathematical model for relative quantification in real time RT-PCR, Nucleic Acids Res., 28, 2002 Schroedl, 2002, Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species, Am. J. Physiol. Lung Cell. Mol. Physiol., 283, L922, 10.1152/ajplung.00014.2002 Semenza, 2000, HIF-1 and human disease: one highly involved factor, Genes Dev., 14, 1983, 10.1101/gad.14.16.1983 Seo, 1998, Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells, Proc. Natl. Acad. Sci. USA, 95, 9167, 10.1073/pnas.95.16.9167 Schofield, 2004, Oxygen sensing by HIF hydroxylases. Oxygen sensing by HIF hydroxylases, Nat. Rev. Mol. Cell Biol., 5, 343, 10.1038/nrm1366 Srinivas, 2001, Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway, J. Biol. Chem., 276, 21995, 10.1074/jbc.C100177200 Tiranti, 1998, Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiency, Am. J. Hum. Genet., 63, 1609, 10.1086/302150 Tiranti, 1999, Characterization of SURF-1 expression and Surf-1p function in normal and disease conditions, Hum. Mol. Genet., 8, 2533, 10.1093/hmg/8.13.2533 Vaux, 2001, Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain, Blood, 98, 296, 10.1182/blood.V98.2.296 Wu, 1999, Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1, Cell, 98, 115, 10.1016/S0092-8674(00)80611-X