The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer

Jemal, 2009, Cancer statistics, 2009, CA Cancer J. Clin., 59, 225, 10.3322/caac.20006 Landen, 2008, Early events in the pathogenesis of epithelial ovarian cancer, J. Clin. Oncol., 26, 995, 10.1200/JCO.2006.07.9970 Shih, 2004, p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations, Am. J. Surg. Pathol., 28, 1177, 10.1097/01.pas.0000130325.66448.a1 Levanon, 2008, New insights into the pathogenesis of serous ovarian cancer and its clinical impact, J. Clin. Oncol., 26, 5284, 10.1200/JCO.2008.18.1107 Bruchim, 2004, Analyses of p53 expression pattern and BRCA mutations in patients with double primary breast and ovarian cancer, Int. J. Gynecol. Cancer, 14, 251, 10.1111/j.1048-891X.2004.014208.x Blank, 2005, Epidermal growth factor receptor inhibitors for the treatment of epithelial ovarian cancer, Oncology, 19, 553 2008, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 455, 1061, 10.1038/nature07385 Jones, 2008, Core signaling pathways in human pancreatic cancers revealed by global genomic analyses, Science, 321, 1801, 10.1126/science.1164368 Parsons, 2008, An integrated genomic analysis of human glioblastoma multiforme, Science, 321, 1807, 10.1126/science.1164382 Schadt, 2005, Embracing complexity, inching closer to reality, Sci. STKE, 2005, pe40, 10.1126/stke.2952005pe40 Liang, 2005, Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme, Proc. Natl. Acad. Sci. U. S. A., 102, 5814, 10.1073/pnas.0402870102 Chen, 2008, Variations in DNA elucidate molecular networks that cause disease, Nature, 452, 429, 10.1038/nature06757 Emilsson, 2008, Genetics of gene expression and its effect on disease, Nature, 452, 423, 10.1038/nature06758 Aksenov, 2005, An integrated approach for inference and mechanistic modeling for advancing drug development, FEBS Lett., 579, 1878, 10.1016/j.febslet.2005.02.012 Koller, 2009 Pearl, 2000