A timely glimpse of memories to come

Learning & Behavior - Tập 51 - Trang 125-126 - 2022
Catalin V. Buhusi1, Mona Buhusi1
1Department of Psychology, Interdisciplinary Program in Neuroscience, USTAR BioInnovations Center, Utah State University, Logan, USA

Tóm tắt

Research in the last century has provided insight into the systems, cellular, and molecular processes involved in the formation, storage, recall, and update of memory engrams – the physical manifestation of the long sought-after philosophical and psychological concept of memory traces. Recent technologies allow scientists to visualize the key molecular players involved in segregating, ordering, and linking memories close in time, for future treatment of “disorders of the engram” where memory linking is deficient (e.g., cognitive aging or Alzheimer’s) or excessive (e.g., PTSD).

Tài liệu tham khảo

Asok, A., Leroy, F., Rayman, J. B., & Kandel, E. R. (2019). Molecular Mechanisms of the Memory Trace. Trends in Neurosciences, 42(1), 14–22. https://doi.org/10.1016/j.tins.2018.10.005 Lau, J. M. H., Rashid, A. J., Jacob, A. D., Frankland, P. W., Schacter, D. L., & Josselyn, S. A. (2020). The role of neuronal excitability, allocation to an engram and memory linking in the behavioral generation of a false memory in mice. Neurobiology of Learning and Memory, 174, 107284. https://doi.org/10.1016/j.nlm.2020.107284 Necula, D., Riviere-Cazaux, C., Shen, Y., & Zhou, M. (2021). Insight into the roles of CCR5 in learning and memory in normal and disordered states. Brain, Behavior, and Immunity, 92, 1–9. https://doi.org/10.1016/j.bbi.2020.11.037 Ortega-de San Luis, C., & Ryan, T. J. (2022). Understanding the physical basis of memory: Molecular mechanisms of the engram. The Journal of Biological Chemistry, 298(5), 101866. https://doi.org/10.1016/j.jbc.2022.101866 Shen, Y., Zhou, M., Cai, D., Filho, D. A., Fernandes, G., Cai, Y., ... Silva, A. J. (2022). CCR5 closes the temporal window for memory linking. Nature, 606(7912), 146-152. https://doi.org/10.1038/s41586-022-04783-1