Manthar Ali Mallah1, Min Liu2, Yu Liu2, Hai-Feng Xu2, Xiao-Jun Wu3, Xiao-Tian Chen1, Hui Wang1, Chun-Lan Liu1, Yuan-Rui Tian1, Meng-Xia Li1, Qun Li4, Jun Fu4, Chong Shen1
1Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China
2Center for Disease Control and Prevention of Jurong City, Jurong, Jiangsu 212402, China
3Affiliated Jurong Hospital of Jiangsu University, People's Hospital of Jurong City, Jurong, Jiangsu 214200, China
4Department of Clinical Nutrition, Affiliated Yifu Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China
Tóm tắt
AbstractObjectiveHandgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a Chinese Han Population.MethodsA total of 11,151 subjects mainly consisting of a rural population were recruited with a multi‐stage sampling method in Jurong city, Jiangsu Province, China. Besides hypertension and diabetes, major chronic diseases were excluded. HGS was categorized into tertiles by age and gender. Logistic regression was used to estimate the association of HGS and hypertension with the odds ratio (OR) and 95% confidence interval (CI).ResultsFrom low to high tertiles of HGS, diastolic blood pressure (DBP) was significantly increased (74.52 ± 7.39, 74.70 ± 7.03, and 75.54 ± 7.01 mmHg, respectively; Ptrend = 0.001), as well as in females (Ptrend=0.003). The differences in DBP among the tertiles of HGS were still significant in females even after adjusting for covariates (Ptrend=0.048). No significant differences in systolic blood pressure (SBP) were observed among the tertiles of HGS (P>0.05). Compared to low HGS, high HGS was significantly associated with hypertension after adjustment for age and gender (adjusted OR, 1.19; 95% CI, 1.06–1.34; P =0.004). A stratified analysis showed that the significant association of high HGS and hypertension was also observed with the following factors even after adjusting for age and gender: female gender (adjusted OR, 1.25; 95% CI, 1.08–1.46; P=0.004), ages of 60–69 years (adjusted OR, 1.29; 95% CI, 1.06–1.57; P=0.011), and married (adjusted OR, 1.20; 95% CI, 1.06–1.37; P=0.005). However, no significant associations were found after adjusting for age, gender, smoking status, drinking status, body mass index, physical activity level, glucose, high‐ and low‐density lipoprotein cholesterol, total cholesterol, and triglyceride (P>0.05).ConclusionThe findings of the current study suggest that HGS was positively correlated with DBP in a rural population, and high HGS was associated with hypertension in females; however, the association may be modified by smoking status, drinking status, body mass index, physical activity, cholesterol level, and glucose level. Further utilization of HGS exercises to intervene in the development and prognosis of hypertension should be verified in the future.
