Innate type 2 cells and asthma

Current Opinion in Pharmacology - Tập 12 - Trang 503-509 - 2012
Emily Hams1,2, Padraic G Fallon1,2,3
1Institute of Molecular Medicine, Trinity College Dublin, Ireland.
2National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin, Ireland
3Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland

Tài liệu tham khảo

Zhang, 2012, Genetic and genomic approaches to asthma: new insights for the origins, Curr Opin Pulm Med, 18, 6, 10.1097/MCP.0b013e32834dc532 Gauvreau, 2011, Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma, Am J Respir Crit Care Med, 183, 1007, 10.1164/rccm.201008-1210OC Holgate, 2011, Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?, J Allergy Clin Immunol, 128, 495, 10.1016/j.jaci.2011.06.052 Kim, 2011, Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity, J Allergy Clin Immunol, 129, 216, 10.1016/j.jaci.2011.10.036 Braman, 2006, The global burden of asthma, Chest, 130, 4S, 10.1378/chest.130.1_suppl.4S Strachan, 1989, Hay fever, hygiene, and household size, BMJ, 299, 1259, 10.1136/bmj.299.6710.1259 Wills-Karp, 2001, The germless theory of allergic disease: revisiting the hygiene hypothesis, Nat Rev Immunol, 1, 69, 10.1038/35095579 Ngoi, 2011, The role of microbial byproducts in protection against immunological disorders and the hygiene hypothesis, Discov Med, 12, 405 Hilty, 2010, Disordered microbial communities in asthmatic airways, PLoS ONE, 5, e8578, 10.1371/journal.pone.0008578 Lambrecht, 2012, Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology, Annu Rev Immunol, 30, 243, 10.1146/annurev-immunol-020711-075021 Lloyd, 2010, Asthma and allergy: the emerging epithelium, Nat Med, 16, 273, 10.1038/nm0310-273 Ege, 2011, Exposure to environmental microorganisms and childhood asthma, N Engl J Med, 364, 701, 10.1056/NEJMoa1007302 Fallon, 2007, Suppression of TH2-type allergic reactions by helminth infection, Nat Rev Immunol, 7, 220, 10.1038/nri2039 Barlow, 2011, Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity, J Allergy Clin Immunol, 129, 191, 10.1016/j.jaci.2011.09.041 Bartemes, 2011, IL-33-responsive lineage-CD25+ CD44hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs, J Immunol, 88, 1503 Ikutani, 2011, Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity, J Immunol, 188, 703, 10.4049/jimmunol.1101270 Monticelli, 2011, Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus, Nat Immunol, 12, 1045, 10.1038/ni.2131 Chang, 2011, Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity, Nat Immunol, 12, 631, 10.1038/ni.2045 Mjosberg, 2011, Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161, Nat Immunol, 12, 1055, 10.1038/ni.2104 Oliphant, 2011, Insights into the initiation of type 2 immune responses, Immunology, 134, 378, 10.1111/j.1365-2567.2011.03499.x Molfino, 2012, Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor, Clin Exp Allergy, 42, 712, 10.1111/j.1365-2222.2011.03854.x Borish, 2001, Efficacy of soluble IL-4 receptor for the treatment of adults with asthma, J Allergy Clin Immunol, 107, 963, 10.1067/mai.2001.115624 Hart, 2002, Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma, Clin Exp Immunol, 130, 93, 10.1046/j.1365-2249.2002.01973.x Oh, 2010, An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males, Br J Clin Pharmacol, 69, 645, 10.1111/j.1365-2125.2010.03647.x Zhou, 2005, Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice, Nat Immunol, 6, 1047, 10.1038/ni1247 Shikotra, 2011, Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma, J Allergy Clin Immunol, 129, 104, 10.1016/j.jaci.2011.08.031 Schmitz, 2005, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity, 23, 479, 10.1016/j.immuni.2005.09.015 Oboki, 2010, IL-33 is a crucial amplifier of innate rather than acquired immunity, Proc Natl Acad Sci USA, 107, 18581, 10.1073/pnas.1003059107 Fort, 2001, IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo, Immunity, 15, 985, 10.1016/S1074-7613(01)00243-6 Angkasekwinai, 2007, Interleukin 25 promotes the initiation of proallergic type 2 responses, J Exp Med, 204, 1509, 10.1084/jem.20061675 Ballantyne, 2007, Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma, J Allergy Clin Immunol, 120, 1324, 10.1016/j.jaci.2007.07.051 Jung, 2009, Association of IL-17RB gene polymorphism with asthma, Chest, 135, 1173, 10.1378/chest.08-1595 Fallon, 2006, Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion, J Exp Med, 203, 1105, 10.1084/jem.20051615 Neill, 2010, Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity, Nature, 464, 1367, 10.1038/nature08900 Moro, 2010, Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells, Nature, 463, 540, 10.1038/nature08636 Souwer, 2010, IL-17 and IL-22 in atopic allergic disease, Curr Opin Immunol, 22, 821, 10.1016/j.coi.2010.10.013 Wenzel, 1997, Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids, Am J Respir Crit Care Med, 156, 737, 10.1164/ajrccm.156.3.9610046 Wang, 2010, A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma, J Exp Med, 207, 2479, 10.1084/jem.20101376 Kudo, 2012, IL-17A produced by alphabeta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction, Nat Med, 18, 547, 10.1038/nm.2684 Saenz, 2010, IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses, Nature, 464, 1362, 10.1038/nature08901 Price, 2010, Systemically dispersed innate IL-13-expressing cells in type 2 immunity, Proc Natl Acad Sci USA, 107, 11489, 10.1073/pnas.1003988107 Wong, 2010, Transcription factor RORalpha is critical for nuocyte development, Nat Immunol, 13, 229, 10.1038/ni.2208 Cupedo, 2009, Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells, Nat Immunol, 10, 66, 10.1038/ni.1668 Cella, 2009, A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity, Nature, 457, 722, 10.1038/nature07537 Halim, 2012, Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation, Immunity, 36, 451, 10.1016/j.immuni.2011.12.020 Moffatt, 2011, A large-scale, consortium-based genomewide association study of asthma, N Engl J Med, 363, 1211, 10.1056/NEJMoa0906312