Cytoskeletal changes in cell transformation and tumorigenesis

Button, 1995, Actin, its associated proteins and metastasis, Cell Motil Cytoskeleton, 30, 247, 10.1002/cm.970300402 Gluck, 1993, Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with α-actinin, Proc Natl Acad Sci USA, 90, 383, 10.1073/pnas.90.2.383 Nikolopoulos, 2000, The human non-muscle α-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells, Oncogene, 19, 380, 10.1038/sj.onc.1203310 Tanaka, 1995, Gelsolin: a candidate for suppressor of human bladder cancer, Cancer Res, 55, 3228 Janke, 2000, Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1, J Exp Med, 191, 1675, 10.1084/jem.191.10.1675 Rodriguez-Fernandez, 1992, Suppression of tumorigenicity in transformed cells after transfection with vinculin, J Cell Biol, 119, 427, 10.1083/jcb.119.2.427 Prasad, 1993, Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene, Proc Natl Acad Sci USA, 90, 7039, 10.1073/pnas.90.15.7039 Prasad, 1999, Suppression of src-induced transformed phenotype by expression of tropomyosin-1, Oncogene, 18, 2027, 10.1038/sj.onc.1202264 Takenaga, 1994, Restoration of microfilament bundle organization in v-raf-transformed NRK cells after transduction with tropomyosin 2 cDNA, Cancer Lett, 87, 47, 10.1016/0304-3835(94)90408-1 Gimona, 1996, Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects, Proc Natl Acad Sci USA, 93, 9618, 10.1073/pnas.93.18.9618 Braverman, 1996, Anti-oncogenic effects of tropomyosin: isoform specificity and importance of protein coding sequences, Oncogene, 13, 537 Janssen, 1997, Tropomyosin-2 cDNA lacking the 3′ untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts, Mol Biol Cell, 8, 897, 10.1091/mbc.8.5.897 Hall, 1998, Rho GTPases and the actin cytoskeleton, Science, 279, 509, 10.1126/science.279.5350.509 Schoenwaelder, 1999, Bidirectional signaling between the cytoskeleton and integrins, Curr Opin Cell Biol, 11, 274, 10.1016/S0955-0674(99)80037-4 Hernandez-Alcoceba, 2000, The ras family of GTPases in cancer cell invasion, Cell Mol Life Sci, 57, 65, 10.1007/s000180050499 Evers, 2000, Rho family proteins in cell adhesion and cell migration, Eur J Cancer, 36, 1269, 10.1016/S0959-8049(00)00091-5 Shields, 2000, Understanding Ras: ‘it ain't over ‘til it's over’, Trends Cell Biol, 10, 147, 10.1016/S0962-8924(00)01740-2 Izawa, 1998, Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation, Oncogene, 17, 2863, 10.1038/sj.onc.1202213 Sahai, 1999, Transformation mediated by RhoA requires activity of ROCK kinases, Curr Biol, 9, 136, 10.1016/S0960-9822(99)80067-0 Pittenger, 1994, Functional properties of non-muscle tropomyosin isoforms, Curr Opin Cell Biol, 6, 96, 10.1016/0955-0674(94)90122-8 Bhattacharya, 1990, Tropomyosins of human mammary epithelial cells: consistent defects of expression in mammary carcinoma cell lines, Cancer Res, 50, 2105 Franzen, 1996, Expression of tropomyosin isoforms in benign and malignant human breast lesions, Brit J Cancer, 73, 909, 10.1038/bjc.1996.162 Wang, 1996, Two differentially expressed genes in normal human prostate tissue and in carcinoma, Cancer Res, 56, 3634 Clark, 2000, Genomic analysis of metastasis reveals an essential role for RhoC, Nature, 406, 532, 10.1038/35020106 Bittner, 2000, Molecular classification of cutaneous malignant melanoma by gene expression profiling, Nature, 406, 536, 10.1038/35020115 Coller, 2000, Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in cell growth, cell cycle, signaling, and adhesion, Proc Natl Acad Sci USA, 97, 3260, 10.1073/pnas.97.7.3260 Janssen, 1998, Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent, J Biol Chem, 273, 32182, 10.1074/jbc.273.48.32182 Ljungdahl, 1998, Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop, Cell Growth Diff, 9, 565 Lamb, 2000, The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho, Nat Cell Biol, 2, 281, 10.1038/35010550 Quang, 2000, Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes, EMBO J, 19, 4565, 10.1093/emboj/19.17.4565 Joos, 1995, Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformation, Oncogene, 10, 603 Lamb, 1997, Essential function of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts, Curr Biol, 7, 682, 10.1016/S0960-9822(06)00295-8 Akisawa, 1999, High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential, Biochem Biophys Res Commun, 258, 398, 10.1006/bbrc.1999.0653 Ohtani, 1999, Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion in endometrial cancer cells, Cancer Lett, 147, 31, 10.1016/S0304-3835(99)00272-4 Mangeat, 1999, ERM proteins in cell adhesion and membrane dynamics, Trends Cell Biol, 9, 187, 10.1016/S0962-8924(99)01544-5 Tikoo, 1994, An anti-ras function of neurofibromatosis type 2 gene product (NF2/Merlin), J Biol Chem, 269, 23387, 10.1016/S0021-9258(17)31525-9 Lutchman, 1995, The neurofibromatosis type 2 gene product, schwannomin, suppresses growth in NIH 3T3 cell, Cancer Res, 55, 2270 Qiu, 1995, A role for rho in ras transformation, Proc Natl Acad Sci USA, 92, 11781, 10.1073/pnas.92.25.11781 Habets, 1994, Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins, Cell, 77, 537, 10.1016/0092-8674(94)90216-X Bourguignon, 2000, Ankyrin–Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration, J Cell Biol, 150, 177, 10.1083/jcb.150.1.177 De Matteis, 1998, The role of ankyrin and spectrin in membrane transport and domain formation, Curr Opin Cell Biol, 10, 542, 10.1016/S0955-0674(98)80071-9 Ben-Ze'ev, 1997, The role of the cytoskeleton in adhesion-mediated signaling and gene expression, Adv Mol Cell Biol, 24, 125, 10.1016/S1569-2558(08)60215-5 Aplin, 1998, Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins, Pharmacol Rev, 50, 197 Van Aelst, 1997, Rho GTPases and signaling networks, Genes Dev, 11, 2295, 10.1101/gad.11.18.2295 Kimura, 1996, Regulation of myosin phosphatase by rho and rho-associated kinase (rho-kinase), Science, 273, 245, 10.1126/science.273.5272.245 Bershadsky, 1996, Involvement of microtubules in the control of adhesion-dependent signal transduction, Curr Biol, 6, 1279, 10.1016/S0960-9822(02)70714-8 Chrzanowska-Wodnicka, 1996, Rho-stimulated contractility drives the formation of stress fibers and focal adhesions, J Cell Biol, 133, 1403, 10.1083/jcb.133.6.1403 Zhang, 1997, Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through rho-dependent actin stress fiber formation and cell contraction, Mol Biol Cell, 8, 1415, 10.1091/mbc.8.8.1415 Helfman, 1999, Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions, Mol Biol Cell, 10, 3097, 10.1091/mbc.10.10.3097 Burridge, 1997, Focal adhesion assembly, Trends Cell Biol, 7, 342, 10.1016/S0962-8924(97)01127-6 Kornberg, 1992, Cell adhesions or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase, J Biol Chem, 267, 23439, 10.1016/S0021-9258(18)35853-8 Miyamoto, 1995, Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function, Science, 267, 883, 10.1126/science.7846531 Marston, 1993, The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon, J Biol Chem, 268, 12317, 10.1016/S0021-9258(18)31391-7 Matsumura, 1993, Caldesmon, Curr Opin Cell Biol, 5, 70, 10.1016/S0955-0674(05)80010-9 Somlyo, 1994, Signal transduction and regulation in smooth muscle, Nature, 372, 231, 10.1038/372231a0 Franklin, 1997, Stretch-dependent activation and desensitization of mitogen-activated protein kinase in carotid arteries, Am J Physiol, 273, 1819, 10.1152/ajpcell.1997.273.6.C1819 Van Eyk, 1998, Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle, J Biol Chem, 273, 23433, 10.1074/jbc.273.36.23433 D'Angelo, 1999, Mammal-specific, ERK-dependent, caldesmon phosphorylation in smooth muscle, J Biol Chem, 274, 30115, 10.1074/jbc.274.42.30115 Foster, 2000, Phosphorylation of caldesmon by p21-activated kinase: implications for the Ca2+ sensitivity of smooth muscle contraction, J Biol Chem, 275, 1959, 10.1074/jbc.275.3.1959 Adam, 2000, Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1, J Biol Chem, 275, 12041, 10.1074/jbc.275.16.12041 McManus, 1997, A transformation-associated complex involving tyrosine kinase signal adaptor proteins and caldesmon links v-ErbB signaling to actin stress fiber disassembly, Proc Natl Acad Sci USA, 94, 11351, 10.1073/pnas.94.21.11351 Wang, 1999, Tyrosine phosphorylation of caldesmon is required for the binding to the Shc–Grb2 complex, J Biol Chem, 247, 33807, 10.1074/jbc.274.47.33807 McManus, 2000, An oncogenic epidermal growth factor receptor signals via a p21-activated kinase–caldesmon—myosin phosphotyrosine complex, J Biol Chem, 275, 35328, 10.1074/jbc.M005399200 Mills, 1999, Extranuclear apoptosis: the role of the cytoplasm in the execution phase, J Cell Biol, 146, 703, 10.1083/jcb.146.4.703 Rosen, 2000, Activation of ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix: a mechanism of ras-induced resistance to anoikis in intestinal epithelial cells, J Cell Biol, 149, 447, 10.1083/jcb.149.2.447 Kothakota, 1997, Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis, Science, 278, 294, 10.1126/science.278.5336.294 Janicke, 1998, Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis, J Biol Chem, 273, 15540, 10.1074/jbc.273.25.15540 Van de Water, 2000, Cleavage of the actin-capping protein alpha-adducin at asp-ser-asp633-ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, J Biol Chem, 275, 25805, 10.1074/jbc.M001680200 Suarez-Huerta, 2000, Myosin heavy chain degradation during apoptosis in endothelial cells, Cell Prolif, 33, 101, 10.1046/j.1365-2184.2000.00169.x Posey, 1999, Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation, J Biol Chem, 274, 4259, 10.1074/jbc.274.7.4259 Parlato, 2000, CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway, EMBO J, 19, 5123, 10.1093/emboj/19.19.5123 Yamazaki, 2000, Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis, Exp Cell Res, 259, 64, 10.1006/excr.2000.4970 Meredith, 1993, The extracellular matrix as a survival factor, Mol Biol Cell, 4, 953, 10.1091/mbc.4.9.953 Re, 1994, Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells, J Cell Biol, 127, 537, 10.1083/jcb.127.2.537 Frisch, 1997, Integrins and anoikis, Curr Opin Cell Biol, 9, 701, 10.1016/S0955-0674(97)80124-X Frisch, 1996, Control of adhesion-dependent cell survival by focal adhesion kinase, J Cell Biol, 134, 793, 10.1083/jcb.134.3.793 Ilic, 1998, Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis, J Cell Biol, 143, 547, 10.1083/jcb.143.2.547 Almeida, 2000, Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase, J Cell Biol, 149, 741, 10.1083/jcb.149.3.741 Cho, 2000, Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix, J Cell Biol, 149, 223, 10.1083/jcb.149.1.223 O'Neill, 2000, Integrin signalling: a new Cas(t) of characters enters the stage, Trends Cell Biol, 10, 111, 10.1016/S0962-8924(99)01714-6 Clark, 1995, Integrins and signal transduction pathways: the road taken, Science, 268, 233, 10.1126/science.7716514 Morin, 1999, β-catenin signaling and cancer, Bioessays, 21, 1021, 10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P Orford, 1999, Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest, J Cell Biol, 146, 855, 10.1083/jcb.146.4.855