Purification development of carrier-free 47Sc produced from natTi(n,p) reaction for radiotheranostic applications
Tóm tắt
This work spotlights on the rapid and effective separation method for the no-carrier-added (NCA) 47Sc from natural irradiated Ti target using an anionic exchanger resin; AN-31 impregnated with 4-(2-Pyridylazo) resorcinol (PAR). The newly prepared resin (An-PAR) was characterized by FTIR and SEM. The Influence of pH on the distribution coefficients (Kd) of Sc(III) and Ti(IV) ions was investigated by batch technique and the results revealed that Ti(IV) ions are strongly adsorbed by AN-PAR rather than AN-31, while Sc(III) ions are weakly adsorbed on the both resin materials. The radiochemical separation of 47Sc(III) from irradiated natural Ti target was successfully carried out, where the elution efficiency for 47Sc reached 89 ± 1.5% with high radiochemical, radionuclidic and chemical purities. Our findings thus hold a great promise for the use of 47Sc radioisotope in the preparation of radiopharmaceuticals for theranostics applications.
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