Negative regulation of the peptidylarginine deiminase type IV promoter by NF-κB in human myeloid cells

Arita, 2004, Structural basis for Ca(2+)-induced activation of human PAD4, Nat. Struct. Mol. Biol., 11, 777, 10.1038/nsmb799 Asaga, 2001, Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils, J. Leukoc. Biol., 70, 46, 10.1189/jlb.70.1.46 Barton, 2004, A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population, Arthritis Rheum., 50, 1117, 10.1002/art.20169 Bax, 2011, Genetics of rheumatoid arthritis: what have we learned?, Immunogenetics, 63, 459, 10.1007/s00251-011-0528-6 Bonizzi, 2004, The two NF-kappaB activation pathways and their role in innate and adaptive immunity, Trends Immunol., 25, 280, 10.1016/j.it.2004.03.008 Brink, 2013, Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis, Arthritis Rheum., 65, 899, 10.1002/art.37835 Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385 Cao, 2006, NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages, J. Biol. Chem., 281, 26041, 10.1074/jbc.M602222200 Chang, 2005, Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis, Rheumatology (Oxford), 44, 40, 10.1093/rheumatology/keh414 Chen, 1999, Construction, expression, purification and functional analysis of recombinant NFκB p50:p65 heterodimer, Protein Eng., 12, 423, 10.1093/protein/12.5.423 Elsharkawy, 2010, The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes, J. Hepatol., 53, 519, 10.1016/j.jhep.2010.03.025 Grundstrom, 2004, Bcl-3 and NFkappaB p50–p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells, J. Biol. Chem., 279, 8460, 10.1074/jbc.M312398200 Guolong, 2000, Molecular mechanisms of NF-B activation induced by bacterial lipopolysaccharide through Toll-like receptors, J. Endotoxin Res., 6, 453, 10.1177/09680519000060060701 Harney, 2005, Genetic and genomic studies of PADI4 in rheumatoid arthritis, Rheumatology (Oxford), 44, 869, 10.1093/rheumatology/keh614 Hemmers, 2011, PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection, PLoS ONE, 6, 10, 10.1371/journal.pone.0022043 Israël, 1989 Iwamoto, 2006, Association between PADI4 and rheumatoid arthritis: a meta-analysis, Rheumatology (Oxford), 45, 804, 10.1093/rheumatology/kel023 Jawaheer, 2001, A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases, Am. J. Hum. Genet., 68, 927, 10.1086/319518 Kang, 2007, Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3, Stem Cells Dev., 16, 615, 10.1089/scd.2007.0014 Kolfenbach, 2010, Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis, Arthritis Rheum., 62, 2633, 10.1002/art.27570 Kuryłowicz, 2008, The role of nuclear factor-κB in the development of autoimmune diseases: a link between genes and environment, Acta Biochim. Pol., 55, 629, 10.18388/abp.2008_3023 Lapponi, 2013, Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs, J. Pharmacol. Exp. Ther., 345, 430, 10.1124/jpet.112.202879 Li, 2002, NF-kappaB regulation in the immune system, Nat. Rev. Immunol., 2, 725, 10.1038/nri910 Li, 2010, PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps, J. Exp. Med., 207, 1853, 10.1084/jem.20100239 Liu, 2011, Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4), PLoS ONE, 6, e21314, 10.1371/journal.pone.0021314 Loots, 2000, Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons, Science, 288, 136, 10.1126/science.288.5463.136 Loots, 2002, rVista for comparative sequence-based discovery of functional transcription factor binding sites, Genome Res., 12, 832, 10.1101/gr.225502. Article published online before print in April 2002 Lundberg, 2005, Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity, Arthritis Res. Ther., 7, R458, 10.1186/ar1697 Oeckinghaus, 2009, The NF-kappaB family of transcription factors and its regulation, Cold Spring Harb. Perspect. Biol., 1, a000034, 10.1101/cshperspect.a000034 Plaksin, 1993, KBF1 (p50 NF-kB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells, J. Exp. Med., 177, 1651, 10.1084/jem.177.6.1651 Rantapaa-Dahlqvist, 2003, Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis, Arthritis Rheum., 48, 2741, 10.1002/art.11223 Rohrbach, 2012, Activation of PAD4 in NET formation, Front. Immunol., 3, 360, 10.3389/fimmu.2012.00360 Suzuki, 2003, Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis, Nat. Genet., 34, 395, 10.1038/ng1206 Suzuki, 2007, Citrullination by peptidylarginine deiminase in rheumatoid arthritis, Ann. N. Y. Acad. Sci., 1108, 323, 10.1196/annals.1422.034 Tak, 2001, NF-kappaB: a key role in inflammatory diseases, J. Clin. Invest., 107, 7, 10.1172/JCI11830 Udalova, 2002, Quantitative prediction of NF-kappa B DNA–protein interactions, Proc. Natl. Acad. Sci. U. S. A., 99, 8167, 10.1073/pnas.102674699 Urban, 2006, Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms, Cell. Microbiol., 8, 668, 10.1111/j.1462-5822.2005.00659.x van Boekel, 2002, Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value, Arthritis Res., 4, 87, 10.1186/ar395 van Gaalen, 2004, Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study, Arthritis Rheum., 50, 709, 10.1002/art.20044 Vossenaar, 2004, Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages, Ann. Rheum. Dis., 63, 373, 10.1136/ard.2003.012211 Vossenaar, 2003, Citrullination of synovial proteins in murine models of rheumatoid arthritis, Arthritis Rheum., 48, 2489, 10.1002/art.11229 Wang, 2004, Human PAD4 regulates histone arginine methylation levels via demethylimination, Science, 306, 279, 10.1126/science.1101400 Wang, 2009, Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation, J. Cell Biol., 184, 205, 10.1083/jcb.200806072 Wegner, 2010, Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis, Immunol. Rev., 233, 34, 10.1111/j.0105-2896.2009.00850.x Willis, 2011, N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis, J. Immunol., 186, 4396, 10.4049/jimmunol.1001620 Wong, 2011, Extensive characterization of NF-kappaB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits, Genome Biol., 12, R70, 10.1186/gb-2011-12-7-r70