The Origin and Functions of Exosomes in Cancer
Tóm tắt
Từ khóa
Tài liệu tham khảo
Harding, 1983, Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes, J Cell Biol, 97, 329, 10.1083/jcb.97.2.329
Von Bartheld, 2011, Multivesicular bodies in neurons: distribution, protein content, and trafficking functions, Prog Neurobiol, 93, 313, 10.1016/j.pneurobio.2011.01.003
Ludwig, 2012, Exosomes: small vesicles participating in intercellular communication, Int J Biochem Cell Biol, 44, 11, 10.1016/j.biocel.2011.10.005
He, 2018, Exosome theranostics: biology and translational medicine, Theranostics, 8, 237, 10.7150/thno.21945
Thery, 1999, Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73, J Cell Biol, 147, 599, 10.1083/jcb.147.3.599
Geminard, 2004, Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes, Traffic, 5, 181, 10.1111/j.1600-0854.2004.0167.x
Katoh, 2003, The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting, J Biol Chem, 278, 39104, 10.1074/jbc.M301604200
Tamai, 2010, Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein, Biochem Biophys Res Commun, 399, 384, 10.1016/j.bbrc.2010.07.083
Baietti, 2012, Syndecan-syntenin-ALIX regulates the biogenesis of exosomes, Nat Cell Biol, 14, 677, 10.1038/ncb2502
Colombo, 2013, Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles, J Cell Sci, 126, 5553, 10.1242/jcs.128868
Chen, 2016, Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages, Oncotarget, 7, 67387, 10.18632/oncotarget.11794
Trajkovic, 2008, Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, 319, 1244, 10.1126/science.1153124
Ostrowski, 2010, Rab27a and Rab27b control different steps of the exosome secretion pathway, Nat Cell Biol, 12, su1, 10.1038/ncb2000
Hsu, 2010, Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C, J Cell Biol, 189, 223, 10.1083/jcb.200911018
Kosaka, 2013, Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis, J Biol Chem, 288, 10849, 10.1074/jbc.M112.446831
Guo, 2015, The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes, J Biol Chem, 290, 3455, 10.1074/jbc.M114.605253
Kajimoto, 2013, Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes, Nat Commun, 4, 2712, 10.1038/ncomms3712
Savina, 2003, Exosome release is regulated by a calcium-dependent mechanism in K562 cells, J Biol Chem, 278, 20083, 10.1074/jbc.M301642200
Lehmann, 2008, Senescence-associated exosome release from human prostate cancer cells, Cancer Res, 68, 7864, 10.1158/0008-5472.CAN-07-6538
Hamlett, 2018, Exosomal biomarkers in Down syndrome and Alzheimer’s disease, Free Radic Biol Med, 114, 110, 10.1016/j.freeradbiomed.2017.08.028
Goetzl, 2016, Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease, FASEB J, 30, 3853, 10.1096/fj.201600756R
Hildonen, 2016, Isolation and mass spectrometry analysis of urinary extraexosomal proteins, Sci Rep, 6, 36331, 10.1038/srep36331
Skotland, 2017, Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers, Eur J Cancer, 70, 122, 10.1016/j.ejca.2016.10.011
Haraszti, 2016, High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources, J Extracell Vesicles, 5, 32570, 10.3402/jev.v5.32570
Roberg-Larsen, 2017, Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes, J Steroid Biochem Mol Biol, 169, 22, 10.1016/j.jsbmb.2016.02.006
Raza, 2015, The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells, Mol Cell Biochem, 410, 187, 10.1007/s11010-015-2551-7
Duijvesz, 2013, Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer, PLoS One, 8, e82589, 10.1371/journal.pone.0082589
Wang, 2008, Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth, PLoS One, 3, e2557, 10.1371/journal.pone.0002557
Chiba, 2012, Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines, Oncol Rep, 28, 1551, 10.3892/or.2012.1967
Sohn, 2015, Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma, Exp Mol Med, 47, e184, 10.1038/emm.2015.68
Cazzoli, 2013, MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer, J Thorac Oncol, 8, 1156, 10.1097/JTO.0b013e318299ac32
Pfeffer, 2015, Detection of exosomal miRNAs in the plasma of melanoma patients, J Clin Med, 4, 2012, 10.3390/jcm4121957
Taylor, 2008, MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer, Gynecol Oncol, 110, 13, 10.1016/j.ygyno.2008.04.033
Li, 2016, Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients, Onco Targets Ther, 9, 139, 10.2147/OTT.S95565
Josson, 2015, Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis, Oncogene, 34, 2690, 10.1038/onc.2014.212
Keller, 2011, Body fluid derived exosomes as a novel template for clinical diagnostics, J Transl Med, 9, 86, 10.1186/1479-5876-9-86
Xu, 2015, Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect, RNA Biol, 12, 1355, 10.1080/15476286.2015.1100795
Song, 2016, Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells, Sci Rep, 6, 30165, 10.1038/srep30165
Le, 2017, Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: Reconciling the mechanisms mediating the bystander effect, PLoS One, 12, e0173685, 10.1371/journal.pone.0173685
Skog, 2008, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nat Cell Biol, 10, 1470, 10.1038/ncb1800
Blomme, 2016, Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes, Oncotarget, 7, 83669, 10.18632/oncotarget.13276
Al-Nedawi, 2008, Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells, Nat Cell Biol, 10, 619, 10.1038/ncb1725
Konstantinell, 2016, Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines, Proteomics, 16, 2587, 10.1002/pmic.201600223
Lee, 2014, Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells, Biochem Biophys Res Commun, 451, 295, 10.1016/j.bbrc.2014.07.109
Luga, 2012, Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration, Cell, 151, 1542, 10.1016/j.cell.2012.11.024
Kim, 2014, Enhanced shedding of extracellular vesicles from amoeboid prostate cancer cells: potential effects on the tumor microenvironment, Cancer Biol Ther, 15, 409, 10.4161/cbt.27627
Wu, 2016, Exosomes derived from gastric cancer cells activate NF-kappaB pathway in macrophages to promote cancer progression, Tumour Biol, 37, 12169, 10.1007/s13277-016-5071-5
Nabet, 2017, Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer, Cell, 170, 352, 10.1016/j.cell.2017.06.031
Yogev, 2017, Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs, PLoS Pathog, 13, e1006524, 10.1371/journal.ppat.1006524
Berchem, 2016, Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer, Oncoimmunology, 5, e1062968, 10.1080/2162402X.2015.1062968
Ramteke, 2015, Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules, Mol Carcinog, 54, 554, 10.1002/mc.22124
Nazarenko, 2010, Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation, Cancer Res, 70, 1668, 10.1158/0008-5472.CAN-09-2470
Deregibus, 2007, Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA, Blood, 110, 2440, 10.1182/blood-2007-03-078709
Tadokoro, 2013, Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells, J Biol Chem, 288, 34343, 10.1074/jbc.M113.480822
Gopal, 2016, Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells, Oncotarget, 7, 19709, 10.18632/oncotarget.7573
Hood, 2009, Paracrine induction of endothelium by tumor exosomes, Lab Invest, 89, 1317, 10.1038/labinvest.2009.94
Gesierich, 2006, Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029, Cancer Res, 66, 7083, 10.1158/0008-5472.CAN-06-0391
Jung, 2017, Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells, Oncotarget, 8, 9899, 10.18632/oncotarget.14247
Zhou, 2014, Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis, Cancer Cell, 25, 501, 10.1016/j.ccr.2014.03.007
Thiery, 2009, Epithelial-mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007
Lamouille, 2014, Molecular mechanisms of epithelial-mesenchymal transition, Nat Rev Mol Cell Biol, 15, 178, 10.1038/nrm3758
Liu, 2016, CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent, Gastric Cancer, 19, 754, 10.1007/s10120-015-0523-y
Hoffman, 2013, Stromal-cell and cancer-cell exosomes leading the metastatic exodus for the promised niche, Breast Cancer Res, 15, 310, 10.1186/bcr3426
Costa-Silva, 2015, Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver, Nat Cell Biol, 17, 816, 10.1038/ncb3169
Fabbri, 2012, MicroRNAs bind to toll-like receptors to induce prometastatic inflammatory response, Proc Natl Acad Sci U S A, 109, E2110, 10.1073/pnas.1209414109
Fedele, 2015, The alphavbeta6 integrin is transferred intercellularly via exosomes, J Biol Chem, 290, 4545, 10.1074/jbc.C114.617662
Hoshino, 2015, Tumour exosome integrins determine organotropic metastasis, Nature, 527, 329, 10.1038/nature15756
Jeppesen, 2014, Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors, Proteomics, 14, 699, 10.1002/pmic.201300452
Peinado, 2012, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nat Med, 18, 883, 10.1038/nm.2753
Garnier, 2013, Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state, Exp Cell Res, 319, 2747, 10.1016/j.yexcr.2013.08.003
McCready, 2010, Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation, BMC Cancer, 10, 294, 10.1186/1471-2407-10-294
Zhang, 2015, Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth, Nature, 527, 100, 10.1038/nature15376
Ohshima, 2010, Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line, PLoS One, 5, e13247, 10.1371/journal.pone.0013247
Maji, 2017, Exosomal annexin II promotes angiogenesis and breast cancer metastasis, Mol Cancer Res, 15, 93, 10.1158/1541-7786.MCR-16-0163
Wang, 2015, Investigation of the roles of exosomes in colorectal cancer liver metastasis, Oncol Rep, 33, 2445, 10.3892/or.2015.3843
Ji, 2013, Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components, Proteomics, 13, 1672, 10.1002/pmic.201200562
Chen, 2014, Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs, PLoS One, 9, e95240, 10.1371/journal.pone.0095240
Rabinowits, 2009, Exosomal microRNA: a diagnostic marker for lung cancer, Clin Lung Cancer, 10, 42, 10.3816/CLC.2009.n.006
Qiu, 2018, Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications, Mol Cancer, 17, 2, 10.1186/s12943-017-0755-z
Eichelser, 2014, Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients, Oncotarget, 5, 9650, 10.18632/oncotarget.2520
Ogata-Kawata, 2014, Circulating exosomal microRNAs as biomarkers of colon cancer, PLoS One, 9, e92921, 10.1371/journal.pone.0092921
Matsumura, 2015, Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer, Br J Cancer, 113, 275, 10.1038/bjc.2015.201
Li, 2015, Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer, Tumour Biol, 36, 2007, 10.1007/s13277-014-2807-y
Ke, 2017, The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer, Oncotarget, 8, 21516, 10.18632/oncotarget.15628
Li, 2009, Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer, BMC Cancer, 9, 244, 10.1186/1471-2407-9-244
Ko, 2016, Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices, Analyst, 141, 450, 10.1039/c5an01610j
Kanwar, 2014, Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes, Lab Chip, 14, 1891, 10.1039/c4lc00136b
Yoshioka, 2014, Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen, Nat Commun, 5, 3591, 10.1038/ncomms4591
Zhao, 2016, A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis, Lab Chip, 16, 489, 10.1039/c5lc01117e
Tian, 2018, Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy, Biomaterials, 150, 137, 10.1016/j.biomaterials.2017.10.012
Haney, 2015, Exosomes as drug delivery vehicles for Parkinson’s disease therapy, J Control Release, 207, 18, 10.1016/j.jconrel.2015.03.033
Pascucci, 2014, Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery, J Control Release, 192, 262, 10.1016/j.jconrel.2014.07.042
Aqil, 2017, Exosomal delivery of berry anthocyanidins for the management of ovarian cancer, Food Func, 8, 4100, 10.1039/c7fo00882a
Munagala, 2016, Bovine milk-derived exosomes for drug delivery, Cancer Lett, 371, 48, 10.1016/j.canlet.2015.10.020
Montaner-Tarbes, 2016, Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins, Vet Res, 47, 59, 10.1186/s13567-016-0345-x
Menay, 2017, Exosomes Isolated from Ascites of T-cell lymphoma-bearing mice expressing surface CD24 and HSP-90 induce a tumor-specific immune response, Front Immunol, 8, 286, 10.3389/fimmu.2017.00286
Harshyne, 2015, Glioblastoma exosomes and IGF-1R/AS-ODN are immunogenic stimuli in a translational research immunotherapy paradigm, Cancer Immunol Immunother, 64, 299, 10.1007/s00262-014-1622-z
Bu, 2015, Exosomes from dendritic cells loaded with chaperone-rich cell lysates elicit a potent T cell immune response against intracranial glioma in mice, J Mol Neurosci, 56, 631, 10.1007/s12031-015-0506-9