Inflammation in stroke and focal cerebral ischemia

Surgical Neurology - Tập 66 - Trang 232-245 - 2006
Judy Huang1, Urvashi M. Upadhyay1, Rafael J. Tamargo1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA

Tài liệu tham khảo

Abumiya, 2000, Integrin αIIbβ3 inhibitor preserves microvascular patency in experimental acute focal cerebral Ischemia, Stroke, 31, 1402, 10.1161/01.STR.31.6.1402 Antezana, 2003, High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats, J Neurosurg, 98, 860, 10.3171/jns.2003.98.4.0860 Armstead, 1993, Transforming growth factor–beta attenuates ischemia-induced alterations in cerebrovascular responses, Am J Physiol, 264, H381 Arnould, 1993, Increased PMN adherence on ECs after hypoxia: involvement of PAF, CD11/CD18, and ICAM-1, Am J Physiol, 264, C1102, 10.1152/ajpcell.1993.264.5.C1102 Aspey, 1989, Do leukocytes have a role in the cerebrovascular no-reflow phenomenon?, J Neurol Neurosurg Psychiatry, 52, 526, 10.1136/jnnp.52.4.526 Astrup, 1981, Thresholds in cerebral ischemia—the ischemic penumbra, Stroke, 12, 723, 10.1161/01.STR.12.6.723 Barone, 1992, Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia, Stroke, 23, 1337, 10.1161/01.STR.23.9.1337 Bevilacqua, 1984, Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells, J Exp Med, 160, 618, 10.1084/jem.160.2.618 Bevilacqua, 1986, Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the action of interleukin 1, Proc Natl Acad Sci U S A, 83, 4533, 10.1073/pnas.83.12.4533 Bevilacqua, 1986, Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1, J Clin Invest, 78, 587, 10.1172/JCI112613 Boehringer Ingelheim drops enlimomab for stroke. SCRIP World Pharmaceutical News. April 23, 1997; S00534360F. Bowes, 1993, Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model, Exp Neurol, 119, 215, 10.1006/exnr.1993.1023 Buttini, 1994, Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat, Brain Res Mol Brain Res, 23, 126, 10.1016/0169-328X(94)90218-6 Camarata, 1994, “Brain attack”: the rationale for treating stroke as a medical emergency, Neurosurgery, 34, 144, 10.1227/00006123-199401000-00021 Carter, 1990, Purification, cloning, expression, and biological characterization of an interleukin-1 receptor antagonist protein, Nature, 344, 633, 10.1038/344633a0 Cha, 2002, Surface expression of P-selectin on platelets is related with clinical worsening in acute ischemic stroke, J Korean Med Sci, 117, 811, 10.3346/jkms.2002.17.6.811 Chopp, 1996, Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain, J Cereb Blood Flow Metab, 16, 578, 10.1097/00004647-199607000-00007 Chou, 2004, Neutrophil protein kinase C delta as a mediator of stroke reperfusion injury, J Clin Invest, 114, 10.1172/JCI200421655 Clark RK, Lee EV, Fish CJ, White RF, Price WJ, Jonak ZL, Feuerstein GZ, Barone FC. Development of tissue damage, inflammation and resolution following stroke: an immunohistochemical and quantitative planimetric study. Brain Res Bull 31:565-72. Connolly, 1996, Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke, J Clin Invest, 97, 209, 10.1172/JCI118392 Connolly, 1996, Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia, Neurosurgery, 38, 523 Connolly, 1996, Exacerbation of cerebral injury in mice which express the P-selectin gene: identification of P-selectin blockade as a new target for the treatment of stroke, Circ Res, 81, 304, 10.1161/01.RES.81.3.304 del Zoppo, 1994, Microvascular changes during cerebral ischemia and reperfusion, Cerebrovasc Brain Metab Rev, 6, 47 delZoppo, 1997, Microvascular responses to cerebral ischemia/inflammation, Ann N Y Acad Sci, 823, 132, 10.1111/j.1749-6632.1997.tb48386.x del Zoppo, 1991, Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons, Stroke, 22, 1276, 10.1161/01.STR.22.10.1276 Dereski, 1993, The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat, Acta Neuropathol, 85, 327, 10.1007/BF00227730 Diacovo, 1994, A functional integrin ligand on the surface of platelets: intercellular adhesion molecule–2, J Clin Invest, 94, 1243, 10.1172/JCI117442 Diacovo, 1996, Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2–integrin CD11b/CD18, Blood, 88, 146, 10.1182/blood.V88.1.146.146 Dietrich, 1987, Histopathological and hemodynamic consequences of complete versus incomplete ischemia in the rat, J Cereb Blood Flow Metab, 7, 300, 10.1038/jcbfm.1987.67 Dinarello, 1991, Interleukin-1 and interleukin-1 antagonism, Blood, 77, 1627, 10.1182/blood.V77.8.1627.1627 Dinarello, 1996, Biologic basis for interleukin-1 in disease, Blood, 87, 2095, 10.1182/blood.V87.6.2095.bloodjournal8762095 Dripps, 1991, Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction, J Biol Chem, 266, 10331, 10.1016/S0021-9258(18)99230-6 Ernst, 1987, Leukocyte rheology in recent stroke, Stroke, 18, 59, 10.1161/01.STR.18.1.59 Fassbender, 1995, Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke, Stroke, 26, 1361, 10.1161/01.STR.26.8.1361 Fassbender, 1994, Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease, J Neurol Sci, 122, 135, 10.1016/0022-510X(94)90289-5 Feuerstein, 1994, Cytokines, inflammation, and brain injury: role of tumor necrosis factor–alpha, Cerebrovasc Brain Metab Rev, 6, 341 Frijns, 2002, Inflammatory cell adhesion molecules in ischemic cerebrovascular disease, Stroke, 33, 2115, 10.1161/01.STR.0000021902.33129.69 Garcia, 1995, Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion, Am J Pathol, 147, 1477 Garcia, 1994, Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat), Am J Pathol, 144, 188 Garcia, 1978, Cerebral microvasculature in ischemia, Adv Neurol, 20, 141 Garcia, 1993, Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat, Am J Pathol, 142, 623 Geng, 1990, Rapid neutrophil adhesion to activated endothelium mediated by GMP-140, Nature, 343, 757, 10.1038/343757a0 Ginsberg, 1989, Rodent models of cerebral ischemia, Stroke, 20, 1627, 10.1161/01.STR.20.12.1627 Gourmala, 1997, Differential and time-dependent expression of monocyte chemoattractant protein–1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration, Neuroimmunology, 74, 35, 10.1016/S0165-5728(96)00203-2 Goussev, 1998, P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat, J Neurol Sci, 161, 16, 10.1016/S0022-510X(98)00262-7 Granowitz, 1991, Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II Interleukin-1 receptor, J Biol Chem, 266, 14147, 10.1016/S0021-9258(18)98655-2 Granowitz, 1992, Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1–induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes, Blood, 79, 2356, 10.1182/blood.V79.9.2356.2356 Granowitz, 1992, Effect of Interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes, Blood, 79, 2364, 10.1182/blood.V79.9.2364.2364 Gross, 1993, Transforming growth factor–beta 1 reduces infarct size after experimental cerebral ischemia in a rabbit model, Stroke, 24, 558, 10.1161/01.STR.24.4.558 Gross, 1994, TGF-beta 1 post-treatment in a rabbit model of cerebral ischaemia, Neurol Res, 16, 465, 10.1080/01616412.1994.11740275 Hallenbeck, 1986, Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period, Stroke, 17, 246, 10.1161/01.STR.17.2.246 Hallmann, 1991, The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium, Biochem Biophys Res Commun, 174, 236, 10.1016/0006-291X(91)90511-5 Haring, 1996, Distribution of integrin-like immunoreactivity on primate brain microvasculature, J Neuropathol Exp Neurol, 55, 236, 10.1097/00005072-199602000-00012 Haring, 1996, E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia, Stroke, 27, 1386, 10.1161/01.STR.27.8.1386 Huang, 1999, Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein, Science, 285, 595, 10.1126/science.285.5427.595 Huang, 2000, Postischemic cerebrovascular E-selectin expression mediates tissue injury in murine stroke, Stroke, 31, 3047, 10.1161/01.STR.31.12.3047 Huang, 2001, Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke, Proc Natl Acad Sci U S A, 98, 11720, 10.1073/pnas.171325998 Hess, 1994, ICAM-1 expression on human brain microvascular endothelial cells, Neurosci Lett, 168, 201, 10.1016/0304-3940(94)90450-2 Hess, 1994, Increased expression of ICAM-1 during reoxygenation in brain endothelial cells, Stroke, 25, 1463, 10.1161/01.STR.25.7.1463 Huang, 1994, Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase, Science, 265, 1883, 10.1126/science.7522345 Ivanova, 2002, Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal, Proc Natl Acad Sci U S A, 99, 5579, 10.1073/pnas.082609299 Johnston, 2001, Trophic factor secreting kidney cell lines: in vitro characterization and functional effects following transplantation in ischemic rats, Brain Res, 900, 268, 10.1016/S0006-8993(01)02327-7 Jutila, 1989, Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules, Transplantation, 48, 727, 10.1097/00007890-198911000-00001 Kaplanski, 1994, Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism, Brain Res, 84, 4242 Kim J, Yoon SS, Kim YH, Ryu JS. Serial measurement of interleukin-6, transforming growth factor–beta, and S-100 protein in patients with acute stroke. Stroke 27:1553-7. Klempt, 1992, Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brain, Res Mol Brain Res, 13, 93, 10.1016/0169-328X(92)90048-G Koga, 1992, Synthesis and release of interleukin-1 by reoxygenated human mononuclear phagocytes, J Clin Invest Cell, 90, 1007, 10.1172/JCI115913 Larsen E, Celi A, Gilbert G, Furie BC, Erban J, Bonfanti R, Wagner DD, Furie B. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. 1989;59:305-12. Lawrence, 1991, Leukocytes roll on a selectin at physiological flow rates: distinction from and prerequisite for adhesion through integrins, Cell, 65, 859, 10.1016/0092-8674(91)90393-D Lehrmann, 1995, Cytokines in cerebral ischemia: expression of transforming growth factor beta–1 (TGF-beta 1) mRNA in the postischemic adult rat hippocampus, Exp Neurol, 131, 114, 10.1016/0014-4886(95)90013-6 Ley, 1995, Sequential contribution of L- and P-selectin to leukocyte rolling in vivo, J Exp Med, 181, 669, 10.1084/jem.181.2.669 Li, 1995, A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18, J Cell Biol, 129, 1143, 10.1083/jcb.129.4.1143 Lindsberg, 1996, Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke, Circulation, 94, 939, 10.1161/01.CIR.94.5.939 Liu, 1994, Tumor necrosis factor–alpha expression in ischemic neurons, Stroke, 25, 1481, 10.1161/01.STR.25.7.1481 Liu, 1993, Interleukin-1 beta mRNA expression in ischemic rat cortex, Stroke, 24, 1746, 10.1161/01.STR.24.11.1746 Liu, 1993, Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia, Neurosci Lett, 164, 125, 10.1016/0304-3940(93)90873-J Matsumoto, 1997, Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8, Lab Invest, 77, 119 Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P-selectin deficient mice. 1993;74(3):541-54. McEver, 1991, Leukocyte interactions mediated by selectins, Thromb Haemost, 66, 80, 10.1055/s-0038-1646376 McEver, 1991, Selectins: novel receptors that mediate leukocyte adhesion during inflammation, Thromb Haemost, 65, 223, 10.1055/s-0038-1647488 McIntyre, 1991, Inhibition of Interleukin-1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti–IL-1 receptor monoclonal antibody, J Exp Med, 173, 931, 10.1084/jem.173.4.931 Maestre-Moreno, 2005, Thrombolysis in stroke: inappropriate consideration of the “window period” as the time available, Rev Neurol, 40, 274 McNeill, 1994, Neuronal rescue with TGFβ1 after hypoxic-ischemic brain injury, Neuroreport, 5, 901, 10.1097/00001756-199404000-00012 Minami, 2003, Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury, Life Sci, 74, 321, 10.1016/j.lfs.2003.09.019 Mocco, 2002, HuEP5C7 as a humanized monoclonal anti-E/P Selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke, Circ Res, 91, 907, 10.1161/01.RES.0000042063.15901.20 Moore, 1994, The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyl lactosamine, J Biol Chem, 269, 23318, 10.1016/S0021-9258(17)31656-3 Moore, 1992, Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells, J.Cell Biol, 118, 445, 10.1083/jcb.118.2.445 Mori, 1992, Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons, Stroke, 23, 712, 10.1161/01.STR.23.5.712 Morikawa, 1996, Treatment of focal cerebral ischemia with synthetic oligopeptide corresponding to lectin domain of selectin, Stroke, 27, 951, 10.1161/01.STR.27.5.951 Nawroth, 1986, Modulation of endothelial cell hemostatic properties by tumor necrosis factor, J Exp Med, 163, 740, 10.1084/jem.163.3.740 Niewiarowski, 1994, Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors, Semin Hematol, 31, 289 Nose, 1993, Cytokines and reperfusion injury, J Card Surg, 8, 305, 10.1111/j.1540-8191.1993.tb01329.x Okada, 1996, Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia, Am J Pathol, 149, 37 Okada, 1994, P-selectin and intercellular adhesion molecule–1 expression after focal brain ischemia and reperfusion, Stroke, 25, 202, 10.1161/01.STR.25.1.202 Pantoni, 1998, Cytokines and cell adhesion molecules in cerebral ischemia, Arterioscler Thromb Vasc Biol, 18, 503, 10.1161/01.ATV.18.4.503 Pinsky, 2002, Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain, J Clin Invest, 109, 1031, 10.1172/JCI0210649 Pinsky, 1996, Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation, J Clin Invest, 97, 493, 10.1172/JCI118440 Planas, 2003, Neutrophil Infiltration increases matrix metalloproteinase–9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats, J Cereb Blood Flow Metab, 23, 1430, 10.1097/01.WCB.0000090680.07515.C8 Polmar, 1996, Double-blind, randomized, placebo-controlled, parallel-group trial of the efficacy and safety of enlimomab (anti–ICAM-1) compared to placebo administered within 6 hours of the onset of symptoms for the treatment of acute ischemic stroke Relton, 1996, Peripheral administration of Interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat, Exp Neurol, 138, 206, 10.1006/exnr.1996.0059 Ruocco, 1999, A transforming growth factor-beta antagonist unmasks the neuroprotective role of this endogenous cytokine in excitoxic and ischemic brain injury, J Cereb Blood Flow Metab, 19, 1345, 10.1097/00004647-199912000-00008 Sako, 1993, Expression cloning of a functional glycoprotein ligand for P-selectin, Cell, 75, 1179, 10.1016/0092-8674(93)90327-M Schindler, 1990, Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF, Stroke, 75, 40 Sharbrough, 1973, Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy, Stroke, 4, 674, 10.1161/01.STR.4.4.674 Shreeniwas, 1992, Hypoxia-mediated induction of endothelial cell interleukin-1. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface, J Clin Invest, 90, 2333, 10.1172/JCI116122 Shyu, 1997, Serum levels of intercellular adhesion molecule–1 and E-selectin in patients with acute ischaemic stroke, J Neurol, 244, 90, 10.1007/s004150050055 Sobel, 1990, Intercellular adhesion molecule–1 in cellular immune reactions in the human central nervous system, Am J Pathol, 136, 337 Springer, 1990, Adhesion receptors of the immune system, Nature, 346, 425, 10.1038/346425a0 Stanimirovic, 1997, The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil/HCEC adhesion, J Neuroimmunol, 76, 193, 10.1016/S0165-5728(97)00057-X Stenberg, 1984, Redistribution of alpha-granules and their contents in thrombin-stimulated platelets, J Cell Biol, 98, 748, 10.1083/jcb.98.2.748 Tarkowski, 1995, Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke, Stroke, 26, 1393, 10.1161/01.STR.26.8.1393 Thomas, 1993, Tissue factor contributes to microvascular defects after focal cerebral ischemia, Stroke, 24, 847, 10.1161/01.STR.24.6.847 Tilg, 1994, Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55, Stroke, 83, 113 Trojaborg, 1973, Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy, Electroencephalogr Clin Neurophysiol, 34, 61, 10.1016/0013-4694(73)90151-X Um, 2003, Association of interleukin 1–alpha gene polymorphism with cerebral infarction, Mol Brain Res, 115, 50, 10.1016/S0169-328X(03)00179-7 von Andrian UH, Chambers JD, Berg EL, Michie SA, Brown DA, Karolak D, Ramezani L, Berger EM, Arfors KE, Butcher EC. L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways. Proc Natl Acad Sci USA 82:182-91. von Andrian, 1991, Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo, Proc Natl Acad Sci U S A, 88, 7538, 10.1073/pnas.88.17.7538 Wagner, 1997, Rapid disruption of an astrocyte interaction with the extracellular matrix mediated by integrin alpha 6 beta 4 during focal cerebral ischemia/reperfusion, Stroke, 28, 858, 10.1161/01.STR.28.4.858 Walton, 1998, Activation of p38MAPK in microgliad after ischemia, J Neurochem, 70, 1764, 10.1046/j.1471-4159.1998.70041764.x Wang, 1995, Monocyte chemoattractant protein-1 messenger RNA expression in rat ischemic cortex, Stroke, 26, 661, 10.1161/01.STR.26.4.661 Wang, 1994, Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia, Mol Chem Neuropathol, 23, 103, 10.1007/BF02815404 Wang, 1995, Transforming growth factor–beta 1 exhibits delayed gene expression following focal cerebral ischemia, Brain Res Bull, 36, 607, 10.1016/0361-9230(94)00243-T Wang, 1995, Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex, J Cereb Blood Flow Metab, 15, 166, 10.1038/jcbfm.1995.18 Wang, 2004, Inhibition of MEK/ERK 1 and 2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia, Brain Res, 996, 55, 10.1016/j.brainres.2003.09.074 Weller, 1992, Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha, J Biol Chem, 267, 15176, 10.1016/S0021-9258(18)42162-X Wiessner, 1993, Expression of transforming growth factor–beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia, Acta Neuropathol (Berl), 86, 439, 10.1007/BF00228578 Xu, 1992, Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA, J Immunol, 149, 2650, 10.4049/jimmunol.149.8.2650 Yabuuchi, 1994, An in situ hybridization study on interleukin-1 beta mRNA induced by transient forebrain ischemia in the rat brain, Brain Res Mol Brain Res, 26, 135, 10.1016/0169-328X(94)90084-1 Yamasaki, 1995, Transient increase of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, in ischemic brain areas after focal ischemia in rats, Stroke, 26, 318, 10.1161/01.STR.26.2.318 Yamaski, 1995, Interleukin-1 as a pathogenic mediator of ischemic brain damage in rats, Stroke, 26, 676, 10.1161/01.STR.26.4.676 Yoshimoto, 1997, Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model, Acta Neuropathol (Berl), 93, 154, 10.1007/s004010050596 Zaremba, 2001, Tumor necrosis factor alpha is increased in cerebrospinal fluid and serum of ischemic stroke patients and correlates to volume of evolving brain infarct, Biomed Pharmacother, 55, 258, 10.1016/S0753-3322(01)00058-0 Zhang, 1994, Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat, J Neurol Sci, 125, 3, 10.1016/0022-510X(94)90234-8 Zhang, 1995, Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat, Stroke, 26, 1438, 10.1161/01.STR.26.8.1438 Zhang, 1994, Anti–ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat, Neurology, 44, 1747, 10.1212/WNL.44.9.1747 Zhang, 1995, The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat, Brain Res, 682, 182, 10.1016/0006-8993(95)00346-R Zhang, 1996, E-selectin in focal cerebral ischemia and reperfusion in the rat, J Cereb Blood Flow Metab, 16, 1126, 10.1097/00004647-199611000-00006 Zhang, 1995, Postischemic treatment (2-4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat, Brain Res, 698, 79, 10.1016/0006-8993(95)00830-J Zhang, 1998, The expression of P- and E-selectins in three models of middle cerebral artery occlusion, Brain Res, 785, 207, 10.1016/S0006-8993(97)01343-7 Zhang, 1998, Cerebral vessels express interleukin 1 beta after focal cerebral ischemia, Brain Res, 784, 210, 10.1016/S0006-8993(97)01317-6