An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat
Yolandi van der Merwe1,2,3, Anne E. Faust1,2, Ian Conner1,2, Xinzhu Gu2,4, Firuz Feturi2,5, Wenchen Zhao5, Bianca Leonard2,6, Souvik Roy2,6, Vijay S. Gorantla2,7, Raman Venkataramanan2,5,8, Kia M. Washington2,9,10, William R. Wagner2,3,4, Michael B. Steketee1,11,2,6
1Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States
2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
3Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
4Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States
5Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, United States
6Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States
7Departments of Surgery, Ophthalmology and Bioengineering, Wake Forest School of Medicine, Wake Forest Institute of Regenerative Medicine, Winston Salem, NC, United States
8Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States
9Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, United States
10VA Pittsburgh Healthcare System, Pittsburgh, PA, United States
11Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States