Role of α-tocopherol in cellular signaling: α-tocopherol inhibits stress-induced mitogen-activated protein kinase activation

Plant Biotechnology Reports - Tập 5 - Trang 19-25 - 2010
Tae Kyung Hyun1,2, Kundan Kumar3,2, Kudupudi Prabhakara Rao3,2, Alok Krishna Sinha3,2, Thomas Roitsch1,2
1Department for Plant Physiology, Institute for Plant Science, Karl-Franzens University Graz, Graz, Austria
2Julius-von-Sachs-Institut for Biosicences, University Wuerzburg, Wuerzburg, Germany
3National Institute of Plant Genome Research, New Delhi, India

Tóm tắt

Tocopherols belong to the plant-derived poly phenolic compounds known for antioxidant functions in plants and animals. Activation of mitogen-activated protein kinases (MAPK) is a common reaction of plant cells in defense-related signal transduction pathways. We report a novel non-antioxidant function of α-tocopherol in higher plants linking the physiological role of tocopherol with stress signalling pathways. Pre-incubation of a low concentration of 50 μM α-tocopherol negatively interferes with MAPK activation in elicitor-treated tobacco BY2 suspension culture cells and wounded tobacco leaves, whereas pre-incubated BY2 cells with α-tocopherol phosphate did not show the inhibitory effect on stimuli-induced MAPK activation. The decreased MAPK activity was neither due to a direct inhibitory effect of α-tocopherol nor due to the induction of an inhibitory or inactivating activity directly affecting MAPK activity. The data support that the target of α-tocopherol negatively regulates an upstream component of the signaling pathways that leads to stress dependent MAPK activation.

Tài liệu tham khảo

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