Toll-like receptor function and signaling

Journal of Allergy and Clinical Immunology - Tập 117 Số 5 - Trang 979-987 - 2006
Tsuneyasu Kaisho1, Shizuo Akira2,3
1From RIKEN Research Center for Allergy and Immunology, Kanagawa
2Akira Innate Immunity Project, ERATO, Japan Science and Technology Corporation, Osaka
3Department of Host Defense, Research Institute for Microbial Diseases, Osaka University

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Janeway, 1989, Approaching the asymptote? Evolution and revolution in immunology, Cold Spring Harb Symp Quant Biol, 54, 1, 10.1101/SQB.1989.054.01.003

Medzhitov, 2001, Toll-like receptors and innate immunity, Nat Rev Immunol, 1, 135, 10.1038/35100529

Takeda, 2003, Toll-like receptors, Annu Rev Immunol, 21, 335, 10.1146/annurev.immunol.21.120601.141126

Inohara, 2003, NODs: intracellular proteins involved in inflammation and apoptosis, Nat Rev Immunol, 3, 371, 10.1038/nri1086

Kawai, 2006, Innate immune recognition of viral infection, Nat Immunol, 7, 131, 10.1038/ni1303

Beutler, 2000, Tlr4: central component of the sole mammalian LPS sensor, Curr Opin Immunol, 12, 20, 10.1016/S0952-7915(99)00046-1

Miyake, 2004, Endotoxin recognition molecules, Toll-like receptor 4-MD-2, Semin Immunol, 16, 11, 10.1016/j.smim.2003.10.007

Wagner, 1999, Bacterial CpG DNA activates immune cells to signal infectious danger, Adv Immunol, 73, 329, 10.1016/S0065-2776(08)60790-7

Krieg, 2000, The role of CpG motifs in innate immunity, Curr Opin Immunol, 12, 35, 10.1016/S0952-7915(99)00048-5

Wagner, 2004, The immunobiology of the TLR9 subfamily, Trends Immunol, 25, 381, 10.1016/j.it.2004.04.011

Abbas, 1996, Functional diversity of helper T lymphocytes, Nature, 383, 787, 10.1038/383787a0

Eisenbarth, 2002, Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen, J Exp Med, 196, 1645, 10.1084/jem.20021340

Kaisho, 2002, Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation, Int Immunol, 14, 695, 10.1093/intimm/dxf039

Strachan, 1989, Hay fever, hygiene, and household size, BMJ, 299, 1259, 10.1136/bmj.299.6710.1259

Kim, 1999, Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines, Vaccine, 18, 597, 10.1016/S0264-410X(99)00316-3

Broide, 1998, Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice, J Immunol, 161, 7054, 10.4049/jimmunol.161.12.7054

Kline, 1998, Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma, J Immunol, 160, 2555, 10.4049/jimmunol.160.6.2555

Sur, 1999, Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides, J Immunol, 162, 6284, 10.4049/jimmunol.162.10.6284

Fanucchi, 2004, Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys, Am J Respir Crit Care Med, 170, 1153, 10.1164/rccm.200404-533OC

Shirota, 2000, Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator, J Immunol, 164, 5575, 10.4049/jimmunol.164.11.5575

Tighe, 2000, Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity, J Allergy Clin Immunol, 106, 124, 10.1067/mai.2000.107927

Hessel, 2005, Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction, J Exp Med, 202, 1563, 10.1084/jem.20050631

Liu, 2003, CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells, Nat Immunol, 4, 687, 10.1038/ni941

Dahl, 2004, Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells, Nat Immunol, 5, 337, 10.1038/ni1041

Bashir, 2002, An enteric helminth infection protects against an allergic response to dietary antigen, J Immunol, 169, 3284, 10.4049/jimmunol.169.6.3284

Wohlleben, 2004, Helminth infection modulates the development of allergen-induced airway inflammation, Int Immunol, 16, 585, 10.1093/intimm/dxh062

Mangan, 2006, Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness, J Immunol, 176, 138, 10.4049/jimmunol.176.1.138

Wilson, 2005, Suppression of allergic airway inflammation by helminth-induced regulatory T cells, J Exp Med, 202, 1199, 10.1084/jem.20042572

Barton, 2006, Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA, Nat Immunol, 7, 49, 10.1038/ni1280

Edwards, 2003, Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8alpha+ DC correlates with unresponsiveness to imidazoquinolines, Eur J Immunol, 33, 827, 10.1002/eji.200323797

Gursel, 2003, Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation, J Immunol, 171, 1393, 10.4049/jimmunol.171.3.1393

Kariko, 2005, Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA, Immunity, 23, 165, 10.1016/j.immuni.2005.06.008

Colonna, 2004, Plasmacytoid dendritic cells in immunity, Nat Immunol, 5, 1219, 10.1038/ni1141

Rifkin, 2005, Toll-like receptors, endogenous ligands, and systemic autoimmune disease, Immunol Rev, 204, 27, 10.1111/j.0105-2896.2005.00239.x

Klinman, 2004, Immunotherapeutic uses of CpG oligodeoxynucleotides, Nat Rev Immunol, 4, 249, 10.1038/nri1329

Honda, 2005, Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction, Nature, 434, 1035, 10.1038/nature03547

Kerkmann, 2005, Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells, J Biol Chem, 280, 8086, 10.1074/jbc.M410868200

Akira, 2004, Toll-like receptor signalling, Nat Rev Immunol, 4, 499, 10.1038/nri1391

Kawai, 1999, Unresponsiveness of MyD88-deficient mice to endotoxin, Immunity, 11, 115, 10.1016/S1074-7613(00)80086-2

Suzuki, 2002, IRAK-4 as the central TIR signaling mediator in innate immunity, Trends Immunol, 23, 503, 10.1016/S1471-4906(02)02298-6

Horng, 2002, The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors, Nature, 420, 329, 10.1038/nature01180

Yamamoto, 2002, Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Nature, 420, 324, 10.1038/nature01182

Yamamoto, 2003, Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Science, 301, 640, 10.1126/science.1087262

Yamamoto, 2003, TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Nat Immunol, 4, 1144, 10.1038/ni986

Meylan, 2004, RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation, Nat Immunol, 5, 503, 10.1038/ni1061

Couillault, 2004, TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM, Nat Immunol, 5, 488, 10.1038/ni1060

Covert, 2005, Achieving stability of lipopolysaccharide-induced NF-kappaB activation, Science, 309, 1854, 10.1126/science.1112304

Hemmi, 2003, The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets, J Immunol, 170, 3059, 10.4049/jimmunol.170.6.3059

Kawai, 2004, Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Nat Immunol, 5, 1061, 10.1038/ni1118

Honda, 2004, Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling, Proc Natl Acad Sci U S A, 101, 15416, 10.1073/pnas.0406933101

Honda, 2005, IRF-7 is the master regulator of type-I interferon-dependent immune responses, Nature, 434, 772, 10.1038/nature03464

Uematsu, 2005, Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction, J Exp Med, 201, 915, 10.1084/jem.20042372

Oganesyan, 2006, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response, Nature, 439, 208, 10.1038/nature04374

Hacker, 2006, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369

Takaoka, 2005, Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors, Nature, 434, 243, 10.1038/nature03308

Negishi, 2005, Negative regulation of Toll-like-receptor signaling by IRF-4, Proc Natl Acad Sci U S A, 102, 15989, 10.1073/pnas.0508327102

Yoneyama, 2004, The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Nat Immunol, 5, 730, 10.1038/ni1087

Ishii, 2006, A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA, Nat Immunol, 7, 40, 10.1038/ni1282

Spies, 2003, Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice, J Immunol, 171, 5908, 10.4049/jimmunol.171.11.5908

Babiuk, 2004, TLR9−/− and TLR9+/+ mice display similar immune responses to a DNA vaccine, Immunology, 113, 114, 10.1111/j.1365-2567.2004.01938.x