Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

Experimental Neurology - Tập 213 - Trang 114-121 - 2008
Sung-Chun Tang1,2, Justin D. Lathia, Pradeep K. Selvaraj3, Dong-Gyu Jo4,5, Mohamed R. Mughal4, Aiwu Cheng4, Dominic A. Siler4, William R. Markesbery6, Thiruma V. Arumugam3, Mark P. Mattson4,7
1Stroke Center, Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
2Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Taiwan
3Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA
4Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
5College of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
6Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
7Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Tài liệu tham khảo

Al'Qteishat, 2006, Changes in hyaluronan production and metabolism following ischaemic stroke in man, Brain, 129, 2158, 10.1093/brain/awl139 Asea, 2002, Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4, J. Biol. Chem., 277, 15028, 10.1074/jbc.M200497200 Barton, 2007, Viral recognition by Toll-like receptors, Semin. Immunol., 19, 33, 10.1016/j.smim.2007.01.003 Beutler, 2005, The Toll-like receptors: analysis by forward genetic methods, Immunogenetics, 57, 385, 10.1007/s00251-005-0011-3 Camandola, 2000, The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons, J. Neurochem., 74, 159, 10.1046/j.1471-4159.2000.0740159.x Chen, 2006, Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide, J. Biol. Chem., 281, 3651, 10.1074/jbc.M508125200 Chen, 2004, Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways, Biochem. Biophys. Res. Commun., 324, 1087, 10.1016/j.bbrc.2004.09.157 Cutler, 2004, Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease, Proc. Natl. Acad. Sci. U. S. A., 101, 2070, 10.1073/pnas.0305799101 Doyle, 2006, Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem. Pharmacol., 72, 1102, 10.1016/j.bcp.2006.07.010 Frink, 2007, TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage, Mol. Immunol., 44, 2625, 10.1016/j.molimm.2006.12.009 Hashimoto, 2006, Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta, J. Neurosci. Res., 83, 1039, 10.1002/jnr.20804 Hoebe, 2006, TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy, Curr. Pharm. Des., 12, 4123, 10.2174/138161206778743466 Hu, 1998, Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release, Brain Res., 785, 195, 10.1016/S0006-8993(97)01318-8 Jack, 2005, TLR signaling tailors innate immune responses in human microglia and astrocytes, J. Immunol., 175, 4320, 10.4049/jimmunol.175.7.4320 Jenkins, 1988, Glycosaminoglycans in cortical autopsy samples from Alzheimer brain, J. Neurochem., 51, 1641, 10.1111/j.1471-4159.1988.tb01135.x Jiang, 2005, Regulation of lung injury and repair by Toll-like receptors and hyaluronan, Nat. Med., 11, 1173, 10.1038/nm1315 Keller, 1998, Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system, Rev. Neurosci., 9, 105, 10.1515/REVNEURO.1998.9.2.105 Keller, 1997, Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal, J. Neurochem., 69, 273, 10.1046/j.1471-4159.1997.69010273.x Keller, 1998, Mitochondrial MnSOD prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation and mitochondrial dysfunction, J. Neurosci., 18, 687, 10.1523/JNEUROSCI.18-02-00687.1998 Kigerl, 2007, Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, J. Neurochem., 102, 37, 10.1111/j.1471-4159.2007.04524.x Krishnan, 2007, Toll-like receptor signal transduction, Exp. Mol. Med., 39, 421, 10.1038/emm.2007.47 Kruman, 1997, Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis, J. Neurosci., 17, 5089, 10.1523/JNEUROSCI.17-13-05089.1997 Lafon, 2006, The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA, J. Mol. Neurosci., 29, 185, 10.1385/JMN:29:3:185 Lehnardt, 2003, Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway, Proc. Natl. Acad. Sci. U. S. A., 100, 8514, 10.1073/pnas.1432609100 Liu, 2002, Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide, Infect. Immun., 70, 3433, 10.1128/IAI.70.7.3433-3442.2002 Loo, 1993, Apoptosis is induced by beta-amyloid in cultured central nervous system neurons, Proc. Natl. Acad. Sci. U. S. A., 90, 7951, 10.1073/pnas.90.17.7951 Lotz, 2005, Amyloid beta peptide 1–40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures, J. Neurochem., 94, 289, 10.1111/j.1471-4159.2005.03188.x Lovell, 1997, Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease, Neurobiol. Aging, 18, 457, 10.1016/S0197-4580(97)00108-5 Ma, 2006, Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis, J. Cell Biol., 175, 209, 10.1083/jcb.200606016 Mack, 2006, Temporal pattern of C1q deposition after transient focal cerebral ischemia, J. Neurosci. Res., 83, 883, 10.1002/jnr.20775 Mark, 1997, A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide, J. Neurochem., 68, 255, 10.1046/j.1471-4159.1997.68010255.x Mark, 1997, Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation, J. Neurosci., 17, 1046, 10.1523/JNEUROSCI.17-03-01046.1997 Mattson, 2004, Pathways towards and away from Alzheimer's disease, Nature., 430, 631, 10.1038/nature02621 Mattson, 1998, Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites, Brain Res., 807, 167, 10.1016/S0006-8993(98)00763-X Mollen, 2006, Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage, Shock, 26, 430, 10.1097/01.shk.0000228797.41044.08 Mrak, 2005, Glia and their cytokines in progression of neurodegeneration, Neurobiol. Aging, 26, 349, 10.1016/j.neurobiolaging.2004.05.010 Nataf, 1999, Complement anaphylatoxin receptors on neurons: new tricks for old receptors?, Trends Neurosci., 22, 397, 10.1016/S0166-2236(98)01390-3 Okuno, 2004, The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia, J. Neurosci., 24, 7879, 10.1523/JNEUROSCI.1745-04.2004 Olson, 2004, Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs, J. Immunol., 173, 3916, 10.4049/jimmunol.173.6.3916 Pedersen, 1998, Protein modification by the lipid peroxidation product 4-hydroxynonenal in spinal cord tissue of ALS patients, Ann. Neurol., 44, 819, 10.1002/ana.410440518 Rolls, 2007, Toll-like receptors modulate adult hippocampal neurogenesis, Nat. Cell Biol., 9, 1081, 10.1038/ncb1629 Sayre, 1997, 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease, J. Neurochem., 68, 2092, 10.1046/j.1471-4159.1997.68052092.x Shen, 2003, Yin and Yang: complement activation and regulation in Alzheimer's disease, Prog. Neurobiol., 70, 463, 10.1016/j.pneurobio.2003.08.001 Tahara, 2006, Role of toll-like receptor signalling in Abeta uptake and clearance, Brain, 129, 3006, 10.1093/brain/awl249 Takeda, 2005, Toll-like receptors in innate immunity, Int. Immunol., 17, 1, 10.1093/intimm/dxh186 Tang, 2007, Pivotal role for neuronal toll-like receptors in ischemic brain injury and functional deficits, Proc. Natl. Acad. Sci. U. S. A., 104, 13798, 10.1073/pnas.0702553104 Termeer, 2002, Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4, J. Exp. Med., 195, 99, 10.1084/jem.20001858 Trinchieri, 2007, Cooperation of Toll-like receptor signals in innate immune defence, Nat. Rev., Immunol., 7, 179, 10.1038/nri2038 Troy, 2001, beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation, J. Neurochem., 77, 157, 10.1046/j.1471-4159.2001.t01-1-00218.x Vabulas, 2002, HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway, J. Biol. Chem., 277, 15107, 10.1074/jbc.M111204200 Wiens, 2007, Toll-like receptors are part of the innate immune defense system of sponges (Demospongiae: Porifera), Mol. Biol. Evol., 24, 792, 10.1093/molbev/msl208 Yang, 2005, Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling, Am. J. Physiol, Heart Circ. Physiol., 289, H1069, 10.1152/ajpheart.00143.2005 Yoritaka, 1996, Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc. Natl. Acad. Sci. U. S. A., 93, 2696, 10.1073/pnas.93.7.2696 Yoo, 1999, Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease, J. Neural Transm., Suppl., 57, 315 Walter, 2007, Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease, Cell. Physiol. Biochem., 20, 947, 10.1159/000110455 Zanjani, 2005, Complement activation in very early Alzheimer disease, Alzheimer Dis. Assoc. Disord., 19, 55, 10.1097/01.wad.0000165506.60370.94