Different mutations in SARS-CoV-2 associate with severe and mild outcome

Andersen, 2020, The proximal origin of SARS-CoV-2, Nat Med, 26, 450, 10.1038/s41591-020-0820-9 Roussel, 2020, SARS-CoV-2: fear versus data, Int J Antimicrob Agents, 55, 10.1016/j.ijantimicag.2020.105947 Giraud-Gatineau, 2020, Comparison of mortality associated with respiratory viral infections between December 2019 and March 2020 with that of the previous year in Southeastern France, Int J Infect Dis, 96, 154, 10.1016/j.ijid.2020.05.001 Grasselli, 2020, Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy, JAMA, 10.1001/jama.2020.5394 Wu, 2020, A new coronavirus associated with human respiratory disease in China, Nature, 579, 265, 10.1038/s41586-020-2008-3 Forster, 2020, Phylogenetic network analysis of SARS-CoV-2 genomes, Proc Natl Acad Sci U S A, 117, 9241, 10.1073/pnas.2004999117 Chapman, 1992, Mutational analysis of the coat protein gene of potato virus X: effects on virion morphology and viral pathogenicity, Virology, 191, 223, 10.1016/0042-6822(92)90183-P Tober, 1998, Expression of measles virus V protein is associated with pathogenicity and control of viral RNA synthesis, J Virol, 72, 8124, 10.1128/JVI.72.10.8124-8132.1998 Williams, 1999, A phylogenetically conserved hairpin-type 3′ untranslated region pseudoknot functions in coronavirus RNA replication, J Virol, 73, 8349, 10.1128/JVI.73.10.8349-8355.1999 van Dorp, 2020, Emergence of genomic diversity and recurrent mutations in SARS-CoV-2, Infect Genet Evol, 83, 10.1016/j.meegid.2020.104351 Pachetti, 2020, Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant, J Transl Med, 18, 179, 10.1186/s12967-020-02344-6 Yurkovetskiy, L. et al. SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain. bioRxiv: the preprint server for biology, doi:10.1101/2020.07.04.187757 (2020). Korber, 2020, Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus, Cell, 10.1016/j.cell.2020.06.043 Peng, 2008, Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization, FEBS J, 275, 4152, 10.1111/j.1742-4658.2008.06564.x Dosztanyi, 2005, IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content, Bioinformatics, 21, 3433, 10.1093/bioinformatics/bti541 Yadav, 2020, Virtual screening and dynamics of potential inhibitors targeting RNA binding domain of nucleocapsid phosphoprotein from SARS-CoV-2, Journal of biomolecular structure & dynamics, 1 Angeletti, 2020, COVID-2019: The role of the nsp2 and nsp3 in its pathogenesis, J Med Virol, 92, 584, 10.1002/jmv.25719 Long, S. W. et al. Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area. medRxiv, doi:10.1101/2020.09.22.20199125 (2020). Nakamichi, K. et al. Outcomes associated with SARS-CoV-2 viral clades in COVID-19. medRxiv, doi:10.1101/2020.09.24.20201228 (2020). Young, 2020, Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study, Lancet, 396, 603, 10.1016/S0140-6736(20)31757-8 Liu, 2020, Identification of common deletions in the spike protein of SARS-CoV-2, J Virol Holland, 2020, An 81-Nucleotide Deletion in SARS-CoV-2 ORF7a Identified from Sentinel Surveillance in Arizona (January to March 2020), J Virol, 94, 10.1128/JVI.00711-20 Vijgen, 2005, Genetic variability of human respiratory coronavirus OC43, J Virol, 79, 3223, 10.1128/JVI.79.5.3223-3225.2005