Early Vessel Destabilization Mediated by Angiopoietin-2 and Subsequent Vessel Maturation via Angiopoietin-1 Induce Functional Neovasculature after Ischemia

PLoS ONE - Tập 8 Số 4 - Trang e61831
Di Qin1,2, Teresa Trenkwalder2,3, Seung-Min Lee2, Omary Chillo3, Elisabeth Deindl3, Christian Kupatt4,2, Rabea Hinkel4,2
1Department of Senile Disease, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China
2Medizinische Klinik und Poliklinik I, Klinikum Großhadern, Munich, Germany
3Walter-Brendel-Centre of Experimental Medicine, LMU Munich, Munich, Germany
4DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

S Yla-Herttuala, 2007, Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine, J Am Coll Cardiol, 49, 1015, 10.1016/j.jacc.2006.09.053

R Hinkel, 2011, Gene therapy for ischemic heart disease, Expert Opin Biol Ther, 11, 723, 10.1517/14712598.2011.570749

H Karvinen, 2010, New aspects in vascular gene therapy, Curr Opin Pharmacol, 10, 208, 10.1016/j.coph.2010.01.004

RK Jain, 2003, Molecular regulation of vessel maturation, Nat Med, 9, 685, 10.1038/nm0603-685

JI Greenberg, 2008, A role for VEGF as a negative regulator of pericyte function and vessel maturation, Nature, 456, 809, 10.1038/nature07424

C Kupatt, 2010, Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion: Role of Vessel Maturation, J Am Coll Cardiol, 56, 414, 10.1016/j.jacc.2010.03.050

Y Dor, 2002, Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy, EMBO J, 21, 1939, 10.1093/emboj/21.8.1939

M Thomas, 2009, The role of the Angiopoietins in vascular morphogenesis, Angiogenesis, 12, 125, 10.1007/s10456-009-9147-3

P Saharinen, 2008, Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts, Nat Cell Biol, 10, 527, 10.1038/ncb1715

H Kobayashi, 2006, Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment, Blood, 108, 1260, 10.1182/blood-2005-09-012807

WH Zhu, 2003, Requisite Role of p38 MAPK in Mural Cell Recruitment during Angiogenesis in the Rat Aorta Model, Journal of Vascular Research, 40, 140, 10.1159/000070711

TI Koblizek, 1998, Angiopoietin-1 induces sprouting angiogenesis in vitro, Current Biology, 8, 529, 10.1016/S0960-9822(98)70205-2

NA Abdel-Malak, 2008, Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1GÇôdependent autocrine production of interleukin-8, Blood, 111, 4145, 10.1182/blood-2007-08-110338

T Asahara, 1998, Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization, Circ Res, 83, 233, 10.1161/01.RES.83.3.233

N Arsic, 2003, Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors, Molecular Therapy, 7, 450, 10.1016/S1525-0016(03)00034-0

M Scharpfenecker, 2005, The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism, J Cell Sci, 118, 771, 10.1242/jcs.01653

Y Reiss, 2007, Angiopoietin-2 Impairs Revascularization After Limb Ischemia, Circ Res CIRCRESAHA

H Kidoya, 2012, Biology of the apelin-APJ axis in vascular formation, Journal of Biochemistry, 152, 125, 10.1093/jb/mvs071

PW Raake, 2008, Cardio-specific long-term gene expression in a porcine model after selective pressure-regulated retroinfusion of adeno-associated viral (AAV) vectors, Gene Ther, 15, 12, 10.1038/sj.gt.3303035

GP Gao, 2002, Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy, Proc Natl Acad Sci U S A, 99, 11854, 10.1073/pnas.182412299

JI Pagel, 2012, Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo, Thromb Haemost 107, 562, 10.1160/TH11-07-0490

A Limbourg, 2009, Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia, Nat Protoc, 4, 1737, 10.1038/nprot.2009.185

H Kidoya, 2010, Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia, Blood, 115, 3166, 10.1182/blood-2009-07-232306

M Felcht, 2012, Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling, J Clin Invest, 122, 1991, 10.1172/JCI58832

AH Smith, 2012, Sustained improvement in perfusion and flow reserve after temporally separated delivery of vascular endothelial growth factor and angiopoietin-1 plasmid deoxyribonucleic acid, J Am Coll Cardiol, 59, 1320, 10.1016/j.jacc.2011.12.025

R Sandhu, 2004, Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat, Cardiovasc Res, 64, 115, 10.1016/j.cardiores.2004.05.013

J Holash, 1999, New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF, Oncogene, 18, 5356, 10.1038/sj.onc.1203035

E Fagiani, 2011, Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis, Cancer Research, 71, 5717, 10.1158/0008-5472.CAN-10-4635

M Abe, 2003, Adrenomedullin augments collateral development in response to acute ischemia, Biochem Biophys Res Commun, 306, 10, 10.1016/S0006-291X(03)00903-3

D Scholz, 2002, Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice, J Mol Cell Cardiol, 34, 775, 10.1006/jmcc.2002.2013

A Helisch, 2006, Impact of mouse strain differences in innate hindlimb collateral vasculature, Arterioscler Thromb Vasc Biol, 26, 520, 10.1161/01.ATV.0000202677.55012.a0

T Couffinhal, 1998, Mouse model of angiogenesis, Am J Pathol, 152, 1667