Hyperpolarization-Activated, Cation-Nonselective, Cyclic Nucleotide-Modulated Channel Blockade Alleviates Mechanical Allodynia and Suppresses Ectopic Discharge in Spinal Nerve Ligated Rats

BoSmith, 1993, Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoarterial node cells, Br J Pharmacol, 110, 343, 10.1111/j.1476-5381.1993.tb13815.x Boucher, 2000, Potent analgesic effects of GDNF in neuropathic pain states, Science, 290, 124, 10.1126/science.290.5489.124 Chaplan, 1994, Quantative assessment of tactile allodynia in the rat paw, J Neurosci Methods, 53, 55, 10.1016/0165-0270(94)90144-9 Chaplan, 2003, Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain, J Neurosci, 23, 1169, 10.1523/JNEUROSCI.23-04-01169.2003 Chevaleyre, 2002, Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP, Proc Natl Acad Sci, 99, 9343, 10.1073/pnas.142213199 Devor, 1983, Nerve pathophysiology and mechanisms of pain in causalgia, J Auton Nerv Syst, 7, 371, 10.1016/0165-1838(83)90090-5 Devor, 2001, Neuropathic pain, Acta Anaesthesiol Scand, 45, 1121, 10.1034/j.1399-6576.2001.450912.x DiFrancesco, 1993, Pacemaker mechanisms in cardiac tissue, Annu Rev Physiol, 55, 455, 10.1146/annurev.ph.55.030193.002323 DiFrancesco, 1995, The onset and autonomic regulation of cardiac pacemaker activity, Cardiovasc Res, 29, 449, 10.1016/S0008-6363(96)88518-X Dixon, 1980, Efficient analysis of experimental observations, Ann Rev Pharmacol Toxicol, 20, 441, 10.1146/annurev.pa.20.040180.002301 Eschenfelder, 2000, Dorsal root section elicits signs of neuropathic pain rather than reversing them in rat with L5 spinal nerve injury, Pain, 87, 213, 10.1016/S0304-3959(00)00285-2 Gasparini, 1997, Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neuron, Pflugers Arch, 435, 99, 10.1007/s004240050488 Gold, 2000, Spinal nerve ligation, Pain, 84, 117, 10.1016/S0304-3959(99)00309-7 Han, 2000, Characteristics of ectopic discharges in a rat neuropathic pain model, Pain, 84, 253, 10.1016/S0304-3959(99)00219-5 Harper, 1985, Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons, J Physiol Lond, 359, 31, 10.1113/jphysiol.1985.sp015573 Harris, 1995, Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro, J Neurophysiol, 74, 2366, 10.1152/jn.1995.74.6.2366 Kajander, 1992, Onset of a painful peripheral neuropathy in rat, J Neurophysiol, 68, 734, 10.1152/jn.1992.68.3.734 Kaupp, 2001, Molecular diversity of pacemaker ion channels, Annu Rev Physiol, 63, 235, 10.1146/annurev.physiol.63.1.235 Kim, 1992, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain, 50, 355, 10.1016/0304-3959(92)90041-9 Lamas, 1998, A hyperpolarization-activated cation current (Ih) contributes to resting membrane potential in rat superior cervical sympathetic neurons, Pflugers Arch, 436, 429, 10.1007/s004240050653 Lee, 1999, Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in the neuropathic rat of Lewis strain, J Neurophysiol, 81, 2226, 10.1152/jn.1999.81.5.2226 Li, 2000, Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers, Pain, 85, 493, 10.1016/S0304-3959(00)00250-5 Liu, 2000, Tactile allodynia in the absence of C-fiber activation, Pain, 85, 503, 10.1016/S0304-3959(00)00251-7 Liu, 2000, Spotaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats, Pain, 84, 309, 10.1016/S0304-3959(99)00211-0 Maccaferri, 1996, The hyperpolarization-activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens-alveus interneurones, J Physiol, 497, 119, 10.1113/jphysiol.1996.sp021754 Matzner, 1994, Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels, J Neurophysiol, 72, 349, 10.1152/jn.1994.72.1.349 Pape, 1996, Queer current and pacemaker, Annu Rev Physiol, 58, 299, 10.1146/annurev.ph.58.030196.001503 Rasband, 2001, Distinct potassium channels on pain-sensing neurons, Proc Natl Acad Sci U S A, 98, 13373, 10.1073/pnas.231376298 Ritter, 1992, Somal membrane properties of physiologically identified sensory neurons in the rat, J Neurophysiol, 68, 2033, 10.1152/jn.1992.68.6.2033 Rizzo, 1995, Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurones following axotomy, Neurobiol Dis, 2, 87, 10.1006/nbdi.1995.0009 Rouse, 1994, The haemodynamic actions of ZENECA ZD7288, a novel sino-atrial node function modulator, in the exercising beagle, Br J Pharmacol, 113, 1071, 10.1111/j.1476-5381.1994.tb17102.x Santoro, 1997, Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels, Proc Natl Acad Sci U S A, 94, 14815, 10.1073/pnas.94.26.14815 Santoro, 1998, Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain, Cell, 93, 717, 10.1016/S0092-8674(00)81434-8 Santoro, 1999, The HCN gene family, Ann N Y Acad Sci, 868, 741, 10.1111/j.1749-6632.1999.tb11353.x Satoh, 2000, A bradycardiac agent ZD7288 blocks the hyperpolarization-activated current (I(h)) in retinal rod photoreceptors, Neuropharmacology, 39, 1284, 10.1016/S0028-3908(99)00207-5 Schäfers, 2003, Increased sensitivity of injured adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation, J Neurosci, 23, 3028, 10.1523/JNEUROSCI.23-07-03028.2003 Scroggs, 1994, Variation in IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size, J Neurophysiol, 71, 271, 10.1152/jn.1994.71.1.271 Seutin, 2001, Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons, Neuroreport, 12, 255, 10.1097/00001756-200102120-00015 Sukhotinsky, 2004, Key role of the dorsal root ganglion in neuropathic tactile hypersensibility, Eur J Pain, 8, 135, 10.1016/S1090-3801(03)00086-7 Tagigawa, 1998, A special blocker reveals the presence and function of the hyperpolarization-activated cation current IH in peripheral mammalian nerve fibres, Neuroscience, 82, 631, 10.1016/S0306-4522(97)00383-7 Waddel, 1990, Electrophysiological properties of subpopulations of rat dorsal root ganglion neurons in vitro, Neuroscience, 36, 811, 10.1016/0306-4522(90)90024-X Wu, 2001, Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers, J Neurosci, 21, RC140(1–5), 10.1523/JNEUROSCI.21-08-j0002.2001 Yoon, 1996, Contributions of injured and intact afferents to neuropathic pain in an experimental rat model, Pain, 64, 27, 10.1016/0304-3959(95)00096-8 Zimmermann, 1983, Ethical guidelines for investigations of experimental pain in conscious animals, Pain, 16, 109, 10.1016/0304-3959(83)90201-4