Selection of Solid-State Plasticizers as Processing Aids for Hot-Melt Extrusion

McGinity, 2000, Hot-melt extrusion technology, 203 Zhang, 1999, Properties of sustained-release tablets prepared by hot-melt extrusion, Pharm Dev Technol, 4, 241, 10.1081/PDT-100101358 Follonier, 1994, Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble APIs, Drug Dev Ind Pharm, 20, 1323, 10.3109/03639049409038373 Follonier, 1995, Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained-release pellets prepared using polymeric material, J Control Release, 36, 243, 10.1016/0168-3659(95)00041-6 Aitken-Nichol, 1996, Hot melt extrusion of acrylic films, Pharm Res, 13, 804, 10.1023/A:1016076306279 Cuff, 1998, A preliminary evaluation of injection molding as a technology to produce tablets, Pharm Technol, 22, 96 Breitenbach, 2002, Melt extrusion: from process to API delivery technology, Eur J Pharm Biopharm, 54, 107, 10.1016/S0939-6411(02)00061-9 Miyagawa, 1996, Controlled release of diclofenac sodium from wax matrix granules, Int J Pharm, 138, 215, 10.1016/0378-5173(96)04547-4 Sato, 1997, Dissolution mechanism of diclofenac sodium from wax matrix granules, J Pharm Sci, 86, 929, 10.1021/js960221w Repka, 2000, Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot melt extrusion, Int J Pharm, 202, 63, 10.1016/S0378-5173(00)00418-X Repka, 1999, Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropyl cellulose films prepared by hot melt extrusion, Drug Dev Ind Pharm, 25, 625, 10.1081/DDC-100102218 Tate, 1996, Melt viscosity reduction of poly (ethylene terephthalate) by solvent impregnation, Polymer, 37, 4421, 10.1016/0032-3861(96)00282-0 Bruce, 2005, Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid, Eur J Pharm Biopharm, 59, 85, 10.1016/j.ejpb.2004.06.007 Frohoff-Hulsmann, 1999, Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methyl cellulose as coating material for diffusion pellets, I. Drug release rates from coated pellets, Int J Pharm, 177, 69, 10.1016/S0378-5173(98)00327-5 Gutierrez-Rocca, 1993, Influence of aging on the physical-mechanical properties of acrylic resin films cast from aqueous dispersions and organic solutions, Drug Dev Ind Pharm, 19, 315, 10.3109/03639049309038770 Skultety, 1987, Evaluation of the loss of propylene glycol during aqueous film coating, Drug Dev Ind Pharm, 13, 2209, 10.3109/03639048709020581 Wu, 2003, Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit® RS PO hot-melt extrudates, Eur J Pharm Biopharm, 56, 95, 10.1016/S0939-6411(03)00035-3 Crowley, 2004, The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films, Eur J Pharm Sci, 22, 409, 10.1016/j.ejps.2004.04.005 Verreck, 2005, The effect of pressurized carbon dioxide as a temporary plasticizer and foaming agent on the hot stage extrusion process and extrudate properties of solid dispersions of itraconazole with PVP-VA 64, Eur J Pharm Sci, 26, 349, 10.1016/j.ejps.2005.07.006 Chokshi, 2005, Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion process as a means to manufacture solid dispersion/solution, J Pharm Sci, 94, 2463, 10.1002/jps.20385 Ghebremeskel, 2006, Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: stability testing of selected solid dispersions, Pharm Res, 23, 1928, 10.1007/s11095-006-9034-1 Ghebremeskel, 2007, Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer-surfactant combinations using solubility parameters and testing the processibility, Int J Pharm, 328, 119, 10.1016/j.ijpharm.2006.08.010 Schilling, 2007, Citric acid as a solid-state plasticizer for Eudragit RS PO, J Pharm Pharmacol, 59, 1493, 10.1211/jpp.59.11.0005 Schilling, 2010, Properties of melt extruded enteric matrix pellets, Eur J Pharm Biopharm, 74, 352, 10.1016/j.ejpb.2009.09.008 Thumma, 2008, Influence of plasticizers on the stability and release of a proAPI of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices, Eur J Pharm Biopharm, 70, 605, 10.1016/j.ejpb.2008.06.009 Hildebrand, 1950 Hansen, 1969, The universality of the solubility parameter, Ind Eng Chem Prod Res Dev, 8, 2, 10.1021/i360029a002 Hancock, 1997, The use of solubility parameters in pharmaceutical dosage form design, Int J Pharm, 148, 1, 10.1016/S0378-5173(96)04828-4 Van Krevelen, 1990, 189 Fedors, 1974, A method for estimating both the solubility parameters and molar volumes of liquids, Polym Eng Sci, 14, 147, 10.1002/pen.760140211 Nielson, 1977 Ford, 1987 Mura, 1998, Thermal analysis as a screening technique in preformulation studies on picotinamide solid dosage forms, Drug Dev Ind Pharm, 24, 747, 10.3109/03639049809082722 Forster, 2001, The potential of small-scale fusion experiments and Gordon–Taylor equation to predict the suitability of API/polymer blends for melt extrusion, Drug Dev Ind Pharm, 27, 549, 10.1081/DDC-100105180 Forster, 2003, Comparison of the Gordon-Taylor and Couchan Karasz equations for prediction of the glass transition temperature of glass solutions of API and polyvinylpyrrolidone prepared by melt extrusion, Pharmazie, 58, 838 Barnes, 2001 Ghebre-Sellassie, 2003 Sears, 1982, Plasticizers, 111 Painter, 1997 Greenhalgh, 1999, Solubility parameters as predictors of miscibility in solid dispersions, J Pharm Sci, 88, 1182, 10.1021/js9900856 Vaka, 2014, Excipients for amorphous solid dispersions, 123 Desai, 2007