The CCN family: A new class of inflammation modulators?

Biochimie - Tập 93 - Trang 377-388 - 2011
L. Kular1,2, J. Pakradouni1,2,3, P. Kitabgi1,2, M. Laurent1,2, C. Martinerie1,2
1INSERM, UMR_S 938, Centre de Recherche de Saint-Antoine, Hôpital Saint-Antoine, Paris, F-75012, France
2Université Pierre et Marie Curie - Paris 6, UMR_S 938, Centre de Recherche de Saint-Antoine, Paris, F-75005, France
3SISENE SAS, Paris Biotech Santé, Paris, F-75014, France

Tài liệu tham khảo

Hynes, 2009, The extracellular matrix: not just pretty fibrils, Science, 326, 1216, 10.1126/science.1176009 Bornstein, 2002, Matricellular proteins: extracellular modulators of cell function, Curr. Opin. Cell Biol., 14, 608, 10.1016/S0955-0674(02)00361-7 Llera, 2010, Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer?, Cytokine Growth Factor Rev., 21, 67, 10.1016/j.cytogfr.2009.11.010 Chiodoni, 2010, Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis, Cancer Metastasis Rev., 29, 295, 10.1007/s10555-010-9221-8 Bork, 1993, The modular architecture of a new family of growth regulators related to connective tissue growth factor, FEBS Lett., 327, 125, 10.1016/0014-5793(93)80155-N O’Brien, 1990, Expression of cyr61, a growth factor-inducible immediate-early gene, Mol. Cell Biol., 10, 3569, 10.1128/MCB.10.7.3569 Bradham, 1991, Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10, J. Cell Biol., 114, 1285, 10.1083/jcb.114.6.1285 Joliot, 1992, Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas, Mol. Cell Biol., 12, 10, 10.1128/MCB.12.1.10 Pennica, 1998, WISP genes are members of the connective tissue growth factor family that are up-regulated in human colon tumors, Proc. Natl. Acad. Sci., 95, 14717, 10.1073/pnas.95.25.14717 Brigstock, 2003, Proposal for a unified CCN nomenclature, Mol. Pathol., 56, 127, 10.1136/mp.56.2.127 Perbal, 2005 Chen, 2009, Functions and mechanisms of action of CCN matricellular proteins, Int. J. Biochem. Cell Biol., 41, 771, 10.1016/j.biocel.2008.07.025 Fu, 2004, CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression, J. Biol. Chem., 279, 36943, 10.1074/jbc.M403952200 Li, 2002, A role for CCN3 (NOV) in calcium signalling, Mol. Pathol., 55, 250, 10.1136/mp.55.4.250 Thibout, 2003, Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system, J. Clin. Endocrinol. Metab., 88, 327, 10.1210/jc.2002-020304 Wahab, 2001, Uptake and intracellular transport of the connective tissue growth factor: a potential mode of action, Biochem. J., 359, 89, 10.1042/0264-6021:3590089 Planque, 2006, Nuclear addressing provides a clue for the transforming activity of amino-truncated CCN3 proteins, J. Cell Biochem., 99, 105, 10.1002/jcb.20887 Vallacchi, 2008, CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma, Cancer Res., 68, 715, 10.1158/0008-5472.CAN-07-2103 Wiesman, 2010, CCN5, a secreted protein, localizes to the nucleus, J. Cell Commun. Signal, 4, 91, 10.1007/s12079-010-0087-x Rachfal, 2005, Structural and functional properties of CCN proteins, Vitam. Horm., 70, 69, 10.1016/S0083-6729(05)70003-0 Schober, 2002, Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions, Blood, 99, 4457, 10.1182/blood.V99.12.4457 Bai, 2010, Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages, J. Immunol., 184, 3223, 10.4049/jimmunol.0902792 Cicha, 2005, Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro, Arterioscler. Thromb. Vasc. Biol., 25, 1008, 10.1161/01.ATV.0000162173.27682.7b Sanchez-Lopez, 2009, CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB, J. Am. Soc. Nephrol., 20, 1513, 10.1681/ASN.2008090999 Babic, 1999, Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo, Mol. Cell Biol., 19, 2958, 10.1128/MCB.19.4.2958 Chen, 2001, The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts, J. Biol. Chem., 276, 10443, 10.1074/jbc.M008087200 Leu, 2002, Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells, J. Biol. Chem., 277, 46248, 10.1074/jbc.M209288200 Lin, 2003, CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family, J. Biol. Chem., 278, 24200, 10.1074/jbc.M302028200 Jedsadayanmata, 1999, Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3), J. Biol. Chem., 274, 24321, 10.1074/jbc.274.34.24321 Gawaz, 1997, Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction, Circulation, 96, 1809, 10.1161/01.CIR.96.6.1809 Kubota, 2007, CCN family proteins and angiogenesis: from embryo to adulthood, Angiogenesis, 10, 1, 10.1007/s10456-006-9058-5 Brigstock, 2002, Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61), Angiogenesis, 5, 153, 10.1023/A:1023823803510 Grote, 2007, The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration, Blood, 110, 877, 10.1182/blood-2006-07-036202 Lee, 2007, Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia, Circ. Res., 100, 372, 10.1161/01.RES.0000257945.97958.77 Delmolino, 2001, COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells, J. Cell Physiol., 188, 45, 10.1002/jcp.1100 Shimoyama, 2010, CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration, Arterioscler. Thromb. Vasc. Biol., 30, 675, 10.1161/ATVBAHA.110.203356 Fan, 2000, Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro, Eur. J. Cell Biol., 79, 915, 10.1078/0171-9335-00122 Hishikawa, 1999, Transforming growth factor-beta(1) induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells, Eur. J. Pharmacol., 385, 287, 10.1016/S0014-2999(99)00763-3 Hishikawa, 2000, Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells, Eur. J. Pharmacol., 392, 19, 10.1016/S0014-2999(00)00115-1 Kim, 2004, Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death, J. Virol., 78, 13479, 10.1128/JVI.78.24.13479-13488.2004 Kurozumi, 2008, Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61, Mol. Ther., 16, 1382, 10.1038/mt.2008.112 Wiedmaier, 2008, Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner, Int. J. Med. Microbiol., 298, 231, 10.1016/j.ijmm.2007.06.001 Muehlich, 2004, Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets, Atherosclerosis, 175, 261, 10.1016/j.atherosclerosis.2004.04.011 Sakamoto, 2004, Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid, Endocrinology, 145, 2929, 10.1210/en.2003-1350 Hahn, 2000, Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton, J. Biol. Chem., 275, 37429, 10.1074/jbc.M000976200 Sanjabi, 2009, Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity, Curr. Opin. Pharmacol., 9, 447, 10.1016/j.coph.2009.04.008 Moritani, 2005, Comparable response of ccn1 with ccn2 genes upon arthritis: an in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines, Cell Commun. Signal., 3, 6, 10.1186/1478-811X-3-6 Kok, 2010, Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis, Arthritis Rheum. Zhang, 2009, A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis, Arthritis Rheum., 60, 3602, 10.1002/art.24999 Nozawa, 2009, Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis, Arthritis Res. Ther., 11, R174, 10.1186/ar2863 Lin, 1998, Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells, Cardiovasc. Res., 38, 802, 10.1016/S0008-6363(98)00055-8 Abraham, 2000, Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts, J. Biol. Chem., 275, 15220, 10.1074/jbc.275.20.15220 Dammeier, 1998, Dexamethasone is a novel potent inducer of connective tissue growth factor expression. Implications for glucocorticoid therapy, J. Biol. Chem., 273, 18185, 10.1074/jbc.273.29.18185 Kunzmann, 2007, Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling, J. Allergy Clin. Immunol., 119, 1398, 10.1016/j.jaci.2007.02.018 Karger, 2008, Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells, Cell Signal, 20, 1865, 10.1016/j.cellsig.2008.06.016 Cooker, 2007, TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis, Am. J. Physiol. Ren. Physiol., 293, F157, 10.1152/ajprenal.00508.2006 Keil, 2002, Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells, Kidney Int., 62, 401, 10.1046/j.1523-1755.2002.00462.x Masuko, 2010, Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor, BMC Res. Notes, 3, 5, 10.1186/1756-0500-3-5 Sanchez-Lopez, 2008, Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells, Am. J. Physiol. Ren. Physiol., 294, F149, 10.1152/ajprenal.00129.2007 Xie, 2005, Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells, Am. J. Physiol. Lung Cell Mol. Physiol., 288, L68, 10.1152/ajplung.00156.2004 Fukunaga-Kalabis, 2006, CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1, J. Cell Biol., 175, 563, 10.1083/jcb.200602132 Colston, 2007, Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor, Am. J. Physiol. Heart Circ. Physiol., 293, H1839, 10.1152/ajpheart.00428.2007 Venkatachalam, 2009, WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death, J. Biol. Chem., 284, 14414, 10.1074/jbc.M809757200 Cheon, 2004, Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis, J. Rheumatol., 31, 2106 Parisi, 2006, Expression and regulation of CCN genes in murine osteoblasts, Bone, 38, 671, 10.1016/j.bone.2005.10.005 Lafont, 2005, New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen, J. Bone Miner. Res., 20, 2213, 10.1359/JBMR.050818 Riser, 2009, CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease, Am. J. Pathol., 174, 1725, 10.2353/ajpath.2009.080241 Grotendorst, 1996, A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene, Cell Growth Differ., 7, 469 Grotendorst, 1997, Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts, Cytokine Growth Factor Rev., 8, 171, 10.1016/S1359-6101(97)00010-5 Ryseck, 1991, Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein, Cell Growth Differ., 2, 225 Perbal, 1994, Contribution of MAV-1-induced nephroblastoma to the study of genes involved in human Wilms’ tumor development, Crit. Rev. Oncog., 5, 589 Scholz, 1996, Transcriptional down-regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src, Mol. Cell Biol., 16, 481, 10.1128/MCB.16.2.481 Kawaki, 2008, Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage, J. Bone Miner. Res., 23, 1751, 10.1359/jbmr.080615 Zuo, 2010, The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis, Histol. Histopathol., 25, 795 Perbal, 2001, NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues, Mol. Pathol., 54, 57, 10.1136/mp.54.2.57 Jutel, 2009, Histamine, histamine receptors and their role in immune pathology, Clin. Exp. Allergy, 39, 1786, 10.1111/j.1365-2222.2009.03374.x Cloez-Tayarani, 2007, Nicotine and serotonin in immune regulation and inflammatory processes: a perspective, J. Leukoc. Biol., 81, 599, 10.1189/jlb.0906544 Muller, 2009, 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo, PLoS One, 4, e6453, 10.1371/journal.pone.0006453 Takuwa, 1989, Studies of the mitogenic effect of serotonin in rat renal mesangial cells, Am. J. Physiol., 257, F431 Kasho, 1998, Serotonin enhances the production of type IV collagen by human mesangial cells, Kidney Int., 54, 1083, 10.1046/j.1523-1755.1998.00114.x Grewal, 1999, Serotonin 5-HT2A receptor induces TGF-beta1 expression in mesangial cells via ERK: proliferative and fibrotic signals, Am. J. Physiol., 276, F922 Gupta, 2000, Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis, Kidney Int., 58, 1389, 10.1046/j.1523-1755.2000.00301.x Phanish, 2010, Connective tissue growth factor-(CTGF, CCN2)–a marker, mediator and therapeutic target for renal fibrosis, Nephron Exp. Nephrol., 114, e83, 10.1159/000262316 Xu, 2007, Characterization of a putative intrarenal serotonergic system, Am. J. Physiol. Ren. Physiol., 293, F1468, 10.1152/ajprenal.00246.2007 Li, 2009, Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation–a tale of three gases!, Pharmacol. Ther., 123, 386, 10.1016/j.pharmthera.2009.05.005 Wani, 2007, Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells, Biol. Chem., 388, 497, 10.1515/BC.2007.056 Wang, 2009, Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis, J. Mol. Med., 87, 435, 10.1007/s00109-009-0445-4 Narumiya, 2009, Prostanoids and inflammation: a new concept arising from receptor knockout mice, J. Mol. Med., 87, 1015, 10.1007/s00109-009-0500-1 Ricupero, 1999, Regulation of connective tissue growth factor expression by prostaglandin E(2), Am. J. Physiol., 277, L1165 Yu, 2002, Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor, Arch. Biochem. Biophys., 404, 302, 10.1016/S0003-9861(02)00276-X Black, 2007, Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase, J. Biol. Chem., 282, 15416, 10.1074/jbc.M610432200 Burgess, 2006, Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix, Am. J. Physiol. Lung Cell Mol. Physiol., 290, L153, 10.1152/ajplung.00287.2005 Feitoza, 2008, Inhibition of COX 1 and 2 prior to renal ischemia/reperfusion injury decreases the development of fibrosis, Mol. Med., 14, 724, 10.2119/2008-00064.Feitoza Gashaw, 2008, Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium, Endocrinology, 149, 2261, 10.1210/en.2007-1568 Meyuhas, 2008, A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells, Mol. Cancer Res., 6, 1397, 10.1158/1541-7786.MCR-07-2086 Liang, 2003, Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression, J. Biol. Chem., 278, 27267, 10.1074/jbc.M301009200 Xu, 2009, PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation, Biochem. Biophys. Res. Commun., 381, 625, 10.1016/j.bbrc.2009.02.102 Hashimoto, 2002, Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165, J. Biol. Chem., 277, 36288, 10.1074/jbc.M201674200 Dean, 2007, Mol. Cell Biol., 27, 8454, 10.1128/MCB.00821-07 Eguchi, 2008, Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene, Mol. Cell Biol., 28, 2391, 10.1128/MCB.01288-07 Lin, 2005, Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway, Clin. Cancer Res., 11, 5809, 10.1158/1078-0432.CCR-04-2639 Lin, 2007, Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2, Mol. Cancer Res., 5, 1111, 10.1158/1541-7786.MCR-06-0289 Wang, 2010, Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes, J. Cell Commun. Signal, 4, 15, 10.1007/s12079-009-0083-1 Wu, 2006, Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells, Kidney Int., 69, 248, 10.1038/sj.ki.5000025 Wu, 2008, Signal transduction involved in CTGF-induced production of chemokines in mesangial cells, Growth Factor., 26, 192, 10.1080/08977190802227828 Le Dreau, 2010, NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins, Glia, 58, 1510, 10.1002/glia.21025 Nguyen, 2006, Tumor-derived Cyr61(CCN1) promotes stromal matrix metalloproteinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells, Cancer Res., 66, 2658, 10.1158/0008-5472.CAN-05-2082 Tan, 2009, Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells, Carcinogenesis, 30, 258, 10.1093/carcin/bgn284 Tan, 2009, CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells, J. Cell Biochem., 107, 345, 10.1002/jcb.22132 Blaney Davidson, 2006, Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage, Arthritis Rheum., 54, 1653, 10.1002/art.21795 Fan, 2002, Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells, J. Biol. Chem., 277, 9800, 10.1074/jbc.M111213200 Lin, 2005, Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing, J. Biol. Chem., 280, 8229, 10.1074/jbc.M404903200 Laurent, 2003, NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism, FASEB J., 17, 1919, 10.1096/fj.02-1023fje Soon, 2003, Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation, J. Biol. Chem., 278, 11465, 10.1074/jbc.M210945200 Lake, 2003, CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells, Cell Commun. Signal., 1, 5, 10.1186/1478-811X-1-5 Abreu, 2002, Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta, Nat. Cell Biol., 4, 599, 10.1038/ncb826 Mori, 1999, Role and interaction of connective tissue growth factor with transforming growth factor-b in a persistent mouse fibrosis model, J. Cell Physiol., 181, 153, 10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K Lemaire, 2010, Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome, J. Invest. Dermatol., 130, 1514, 10.1038/jid.2010.15 Chen, 2010, Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines, J. Cell Commun. Signal, 4, 63, 10.1007/s12079-009-0080-4 Chen, 2007, Cytotoxicity of TNF alpha is regulated by integrin-mediated matrix signaling, Embo J., 26, 1257, 10.1038/sj.emboj.7601596 Juric, 2009, Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo, Mol. Cell Biol., 29, 3266, 10.1128/MCB.00064-09 Franzen, 2009, Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis, Mol. Cancer Res., 7, 1045, 10.1158/1541-7786.MCR-09-0017 Mo, 2002, CYR61 (CCN1) is essential for placental development and vascular integrity, Mol. Cell Biol., 22, 8709, 10.1128/MCB.22.24.8709-8720.2002 Ivkovic, 2003, Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development, Development, 130, 2779, 10.1242/dev.00505 Ross, 1999, Atherosclerosis–an inflammatory disease, N. Engl. J. Med., 340, 115, 10.1056/NEJM199901143400207 Hilfiker, 2002, Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II, Circulation, 106, 254, 10.1161/01.CIR.0000021426.87274.62 Sigala, 2006, Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data, Eur. J. Vasc. Endovasc. Surg., 32, 238, 10.1016/j.ejvs.2006.01.026 Oemar, 1997, Human connective tissue growth factor is expressed in advanced atherosclerotic lesions, Circulation, 95, 831, 10.1161/01.CIR.95.4.831 Grzeszkiewicz, 2002, The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans, Endocrinology, 143, 1441, 10.1210/endo.143.4.8731 Matsumae, 2008, CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model, Arterioscler. Thromb. Vasc. Biol., 28, 1077, 10.1161/ATVBAHA.108.162362 Ellis, 2000, Nov gene encodes adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to vascular injury, Arterioscler. Thromb. Vasc. Biol., 20, 1912, 10.1161/01.ATV.20.8.1912 Zimmet, 2005, The metabolic syndrome: a global public health problem and a new definition, J. Atheroscler. Thromb., 12, 295, 10.5551/jat.12.295 Bouchard, 2007, CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals, Clin. Genet., 72, 224, 10.1111/j.1399-0004.2007.00855.x Tan, 2008, Connective tissue growth factor inhibits adipocyte differentiation, Am. J. Physiol. Cell Physiol., 295, C740, 10.1152/ajpcell.00333.2007 Canalis, 2010, Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice, Endocrinology, 10.1210/en.2010-0145 Nakanishi, 2001, Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism, Biochem. Biophys. Res. Commun., 281, 678, 10.1006/bbrc.2001.4379 Smerdel-Ramoya, 2008, Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia, Endocrinology, 149, 4374, 10.1210/en.2008-0254 Manns, 2006, A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor, Arthritis Rheum., 54, 2415, 10.1002/art.22021 Omoto, 2004, Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage, Osteoarthr. Cartil., 12, 771, 10.1016/j.joca.2004.06.009 Nishida, 2004, Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor), J. Bone Miner. Res., 19, 1308, 10.1359/JBMR.040322 Nakao, 2005, Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism, Bone, 36, 884, 10.1016/j.bone.2004.10.015 Haas, 2006, Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins, Arthritis Rheum., 54, 2047, 10.1002/art.21953 Blom, 2009, Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1, Arthritis Rheum., 60, 501, 10.1002/art.24247 Meng, 2005, Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis, Osteoarthr. Cartil., 13, 1115, 10.1016/j.joca.2005.03.010 Glass, 2010, Mechanisms underlying inflammation in neurodegeneration, Cell, 140, 918, 10.1016/j.cell.2010.02.016 Albrecht, 2000, Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61, J. Biol. Chem., 275, 28929, 10.1074/jbc.M003053200 Liu, 1999, Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation, Gene, 238, 471, 10.1016/S0378-1119(99)00364-9 Le Dreau, 2009, NOV/CCN3 promotes maturation of cerebellar granule neuron precursors, Mol. Cell Neurosci. Ueberham, 2003, Connective tissue growth factor in Alzheimer’s disease, Neuroscience, 116, 1, 10.1016/S0306-4522(02)00670-X Zhao, 2005, Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance-associated promotion of Alzheimer’s disease beta-amyloid neuropathology, FASEB J., 19, 2081, 10.1096/fj.05-4359fje Hertel, 2000, Connective tissue growth factor: a novel player in tissue reorganization after brain injury?, Eur. J. Neurosci., 12, 376, 10.1046/j.1460-9568.2000.00930.x Schwab, 2000, Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction, Neuropathol. Appl. Neurobiol., 26, 434, 10.1046/j.1365-2990.2000.00271.x Schwab, 2001, Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans, J. Neurotrauma, 18, 377, 10.1089/089771501750170930 Conrad, 2005, Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells, J. Neurosurg. Spine, 2, 319, 10.3171/spi.2005.2.3.0319 Morrison, 2009, Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity, Toxicol. Pathol., 37, 502, 10.1177/0192623309335631 McClain, 2009, Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration, Neurosci. Lett., 460, 27, 10.1016/j.neulet.2009.05.044 Spliet, 2003, Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cord, Acta Neuropathol., 106, 449, 10.1007/s00401-003-0741-y Wen-Xin, 1996, Differential expression of novH and CTGF in human glioma cell lines, J. Clin. Pathol. Mol. Pathol., 49, M91, 10.1136/mp.49.2.M91 Xie, 2004, Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas, Clin. Cancer Res., 10, 2072, 10.1158/1078-0432.CCR-0659-03 Gupta, 2001, Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV), Mol. Pathol., 54, 293, 10.1136/mp.54.5.293 Sangaletti, 2008, Matricellular proteins at the crossroad of inflammation and cancer, Cancer Lett., 267, 245, 10.1016/j.canlet.2008.03.027 Khatami, 2008, ‘Yin and Yang’ in inflammation: duality in innate immune cell function and tumorigenesis, Expert Opin. Biol. Ther., 8, 1461, 10.1517/14712598.8.10.1461 Colotta, 2009, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis, 30, 1073, 10.1093/carcin/bgp127 Dhar, 2010, The CCN family proteins in carcinogenesis, Exp. Oncol., 32, 2 Leask, 2009, Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2, J. Cell Commun. Signal, 3, 161, 10.1007/s12079-009-0056-4 Brigstock, 2009, Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): from pharmacological inhibition in vitro to targeted siRNA therapy in vivo, J. Cell Commun. Signal, 3, 5, 10.1007/s12079-009-0043-9