No Small Thing: Clinical Implications of Rapid Syndromic Panel-Based Diagnostic Testing in Children

Lukacs, 2012, Clinical sepsis in neonates and young infants, United States, 1988-2006, J Pediatr, 160, 960, 10.1016/j.jpeds.2011.12.023 Leber, 2016, Multicenter evaluation of biofire filmarray meningitis/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens, J Clin Microbiol, 54, 2251, 10.1128/JCM.00730-16 Tansarli, 2020, Diagnostic test accuracy of the BioFire® FilmArray® meningitis/encephalitis panel: a systematic review and meta-analysis, Clin Microbiol Infect, 26, 281, 10.1016/j.cmi.2019.11.016 Arora, 2017, Enhanced identification of group B Streptococcus and Escherichia coli in young infants with meningitis using the Biofire Filmarray Meningitis/Encephalitis Panel, Pediatr Infect Dis J, 36, 685, 10.1097/INF.0000000000001551 Kanegaye, 2001, Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment, Pediatrics, 108, 1169, 10.1542/peds.108.5.1169 Nigrovic, 2007, Risk factors for traumatic or unsuccessful lumbar punctures in children, Ann Emerg Med, 49, 762, 10.1016/j.annemergmed.2006.10.018 Graf, 2017, Comparative evaluation of the FilmArray meningitis/encephalitis molecular panel in a pediatric population, Diagn Microbiol Infect Dis, 87, 92, 10.1016/j.diagmicrobio.2016.09.022 Hagen, 2020, Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study, BMC Pediatr, 20, 1, 10.1186/s12887-020-1944-2 Messacar, 2020, Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period, Diagn Microbiol Infect Dis, 97, 10.1016/j.diagmicrobio.2020.115085 Blaschke, 2018, Retrospective evaluation of infants aged 1 to 60 days with residual cerebrospinal fluid (CSF) tested using the FilmArray meningitis/encephalitis (ME) panel, J Clin Microbiol, 56, 1, 10.1128/JCM.00277-18 Byington, 2004, Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections, Pediatrics, 113, 1662, 10.1542/peds.113.6.1662 Green, 2018, Clinical significance of human herpesvirus 6 positivity on the FilmArray meningitis/encephalitis panel, Clin Infect Dis, 67, 1125, 10.1093/cid/ciy288 Pandey, 2020, Pathogen or bystander: clinical significance of detecting human herpesvirus 6 in pediatric cerebrospinal fluid, J Clin Microbiol, 58, 1, 10.1128/JCM.00313-20 Dierig, 2018, Time-to-positivity of blood cultures in children with sepsis, Front Pediatr, 6, 10.3389/fped.2018.00222 Dodemont, 2014, Performance of the Verigene Gram-negative blood culture assay for rapid detection of bacteria and resistance determinants, J Clin Microbiol, 52, 3085, 10.1128/JCM.01099-14 Salimnia, 2016, Evaluation of the FilmArray blood culture identification panel: results of a multicenter controlled trial, J Clin Microbiol, 54, 687, 10.1128/JCM.01679-15 Vareechon, 2018, A 5-year study of the performance of the Verigene Gram-positive blood culture panel in a pediatric hospital, Eur J Clin Microbiol Infect Dis, 37, 2091, 10.1007/s10096-018-3343-2 Reuter, 2019, Ideal and actual impact of rapid diagnostic testing and antibiotic stewardship on antibiotic prescribing and clinical outcomes in children with positive blood cultures, Pediatr Infect Dis J, 38, 131, 10.1097/INF.0000000000002102 Bonazza S, Bresee LC, Kraft T, Ross BC, Dersch-Mills D. Frequency of and risk factors for acute kidney injury associated with vancomycin use in the pediatric intensive care unit. J Pediatr Pharmacol Ther 21:486-93. Pak, 2020, Rapid diagnostic testing alone does not alter antimicrobial prescribing in children with Staphylococcus aureus bloodstream infection, Pediatr Infect Dis J, 39, E217, 10.1097/INF.0000000000002643 Juttukonda, 2020, Impact of a rapid blood culture diagnostic test in a children's hospital depends on gram-positive versus gram-negative organism and day versus night shift, J Clin Microbiol, 58, 1, 10.1128/JCM.01400-19 Shane, 2017, 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea, Clin Infect Dis, 65, e45, 10.1093/cid/cix669 Buss, 2015, Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis, J Clin Microbiol, 53, 915, 10.1128/JCM.02674-14 O'Neal, 2020, Evaluating appropriateness and diagnostic stewardship opportunities of multiplex polymerase chain reaction gastrointestinal testing within a hospital system, Ther Adv Infect Dis, 7 Smith, 2012, Antibiotic treatment of Escherichia coli O157 infection and the risk of hemolytic uremic syndrome, Minnesota, Pediatr Infect Dis J, 31, 37, 10.1097/INF.0b013e31823096a8 Torres-Miranda, 2020, Use of BioFire FilmArray gastrointestinal PCR panel associated with reductions in antibiotic use, time to optimal antibiotics, and length of stay, BMC Gastroenterol, 20, 246, 10.1186/s12876-020-01394-w Keske, 2018, Rapid molecular detection of gastrointestinal pathogens and its role in antimicrobial stewardship, J Clin Microbiol, 56, 10.1128/JCM.00148-18 Stockmann, 2015, How well does physician selection of microbiologic tests identify Clostridium difficile and other pathogens in paediatric diarrhoea? Insights using multiplex PCR-based detection, Clin Microbiol Infect, 21, 179.e9, 10.1016/j.cmi.2014.07.011 Schutze, 2013, Clostridium difficile infection in infants and children, Pediatrics, 131, 196, 10.1542/peds.2012-2992 Murphy, 2017, Evaluation of the BioFire FilmArray® gastrointestinal panel in a Midwestern academic hospital, Eur J Clin Microbiol Infect Dis, 36, 747, 10.1007/s10096-016-2858-7 Kronman, 2018, Expanding existing antimicrobial stewardship programs in pediatrics: what comes next, J Pediatr Infect Dis Soc, 7, 241, 10.1093/jpids/pix104 Bateman, 2020, Performance and impact of the BioFire filmarray gastrointestinal panel on a large cyclospora outbreak in Wisconsin, 2018, J Clin Microbiol, 58, 2019, 10.1128/JCM.01415-19 Imdad, 2018, Impact of culture-independent diagnostic testing on recovery of enteric bacterial infections, Clin Infect Dis, 66, 1892, 10.1093/cid/cix1128 Huang, 2018, Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis, Clin Microbiol Infect, 24, 1055, 10.1016/j.cmi.2017.11.018 Jain, 2015, Community-acquired pneumonia requiring hospitalization among U.S. children, N Engl J Med, 372, 835, 10.1056/NEJMoa1405870 Subramony, 2016, Impact of multiplex polymerase chain reaction testing for respiratory pathogens on healthcare resource utilization for pediatric inpatients, J Pediatr, 173, 196, 10.1016/j.jpeds.2016.02.050 Lee, 2019, Impact of multiplex molecular assay turn-around-time on antibiotic utilization and clinical management of hospitalized children with acute respiratory tract infections, J Clin Virol, 110, 11, 10.1016/j.jcv.2018.11.006 Rogers, 2015, Impact of a rapid respiratory panel test on patient outcomes, Arch Pathol Lab Med, 139, 636, 10.5858/arpa.2014-0257-OA Rader, 2021, Syndromic multiplex polymerase chain reaction (mPCR) testing and antimicrobial stewardship: current practice and future directions, Curr Infect Dis Rep, 23, 5, 10.1007/s11908-021-00748-z Uyeki, 2019, Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza, Clin Infect Dis, 68, e1, 10.1093/cid/ciy866 Xu, 2013, Implementation of FilmArray respiratory viral panel in a core laboratory improves testing turnaround time and patient care, Am J Clin Pathol, 139, 118, 10.1309/AJCPH7X3NLYZPHBW Fontana, 2019, Respiratory virus infections of the stem cell transplant recipient and the hematologic malignancy patient, Infect Dis Clin North Am, 33, 523, 10.1016/j.idc.2019.02.004 Rhedin, 2014, Clinical utility of PCR for common viruses in acute respiratory illness, Pediatrics, 133, 10.1542/peds.2013-3042 Murphy, 2020, Multicenter evaluation of the BioFire FilmArray pneumonia/pneumonia plus panel for detection and quantification of agents of lower respiratory tract infection, J Clin Microbiol, 58, 10.1128/JCM.00128-20 Buchan, 2020, Practical comparison of the BioFire FilmArray pneumonia panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections, J Clin Microbiol, 58, 10.1128/JCM.00135-20 Willson, 2017, Pediatric ventilator-associated infections: the Ventilator-Associated Infection Study, Pediatr Crit Care Med, 18, e24, 10.1097/PCC.0000000000001001 Monard, 2020, Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia, Crit Care, 24, 434, 10.1186/s13054-020-03114-y Ginocchio, 2021, Multinational Evaluation of the BioFire® FilmArray® Pneumonia plus panel as compared to standard of care testing, Eur J Clin Microbiol Infect Dis, 10.1007/s10096-021-04195-5 Gastli, 2020, Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia, Clin Microbiol Infect, 10.1016/j.cmi.2020.11.014 Administration UFaD Spearman, 2021, Diagnostic testing for SARS-CoV-2/COVID19, Curr Opin Pediatr, 33, 122, 10.1097/MOP.0000000000000972