From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”

Archiv für Kreislaufforschung - Tập 111 - Trang 1-13 - 2016
Hector A. Cabrera-Fuentes1,2,3,4,5, Julian Aragones6, Jürgen Bernhagen7,8, Andreas Boening9, William A. Boisvert4,10, Hans E. Bøtker11, Heerajnarain Bulluck2,3,12, Stuart Cook2,3, Fabio Di Lisa13, Felix B. Engel14, Bernd Engelmann15, Fulvia Ferrazzi16, Péter Ferdinandy17,18, Alan Fong19, Ingrid Fleming20, Erich Gnaiger21, Sauri Hernández-Reséndiz2,3,22, Siavash Beikoghli Kalkhoran12,23, Moo Hyun Kim24, Sandrine Lecour25, Elisa A. Liehn26, Michael S. Marber27, Manuel Mayr28, Tetsuji Miura29, Sang-Bing Ong2,3, Karlheinz Peter30, Daniel Sedding31, Manvendra K. Singh2,3, M. Saadeh Suleiman32, Hans J. Schnittler33, Rainer Schulz34, Winston Shim3, Daniel Tello6, Carl-Wilhelm Vogel35, Malcolm Walker12, Qilong Oscar Yang Li6, Derek M. Yellon12,23, Derek J. Hausenloy2,3,12,23, Klaus T. Preissner1,4
1Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany
2Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore
3National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore
4Department of Microbiology, Kazan Federal University, Kazan, Russian Federation
5Centro de Biotecnología-FEMSA, Tecnológico de Monterrey, Monterrey, Mexico
6Research Unit, Hospital of Santa Cristina, Research Institute Princesa, Autonomous University of Madrid, Madrid, Spain
7Department of Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany
8Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
9Department of Cardiovascular Surgery, Medical School, Justus-Liebig-University, Giessen, Germany
10Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA
11Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark
12The Hatter Cardiovascular Institute, University College London, London, UK
13Department of Biomedical Sciences, University of Padova, Padua, Italy
14Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany
15Institut für Laboratoriumsmedizin, Ludwig-Maximilians-Universität, Munich, Germany
16Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany
17Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
18Pharmahungary Group, Szeged, Hungary
19Department of Cardiology, Sarawak Heart Centre, Sarawak, Malaysia
20Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt, Germany
21D. Swarovski Research Lab, Department of Visceral, Transplant Thoracic Surgery, Medical Univ Innsbruck, Innsbruck, Austria
22Department of Cardiovascular Medicine, National Institute of Cardiology, Ignacio Chavez, Mexico, D.F., Mexico
23The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK
24Department of Cardiology, Dong-A University Hospital, Busan, Korea
25Hatter Institute and MRC Inter-University Cape Heart Unit, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
26Institute for Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
27Department of Cardiology, The Rayne Institute, St Thomas’ Campus, King’s College London, London, UK
28The James Black Centre, King’s College, University of London, London, UK
29Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
30Baker IDI Heart and Diabetes Institute, Melbourne, Australia
31Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
32Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
33Institute of Anatomy and Vascular Biology, Westfalian-Wilhelms-University, Münster, Germany
34Institute of Physiology, Justus-Liebig University, Giessen, Germany
35Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA

Tóm tắt

In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients’ cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia–reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients’ outcome.

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