A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Kidney International - Tập 100 - Trang 196-205 - 2021
Naoka Murakami1, Patrick Mulvaney2, Melissa Danesh2, Ala Abudayyeh3, Adi Diab4, Noha Abdel-Wahab4,5,6, Maen Abdelrahim7, Pascale Khairallah8, Shayan Shirazian8, Aleksandra Kukla9, Itunu O. Owoyemi9, Tarek Alhamad10, Samir Husami10, Madhav Menon11, Andrew Santeusanio11, Christopher D. Blosser12, Sandra Carias Zuniga12, Maria Jose Soler13, Francesc Moreso13, Zain Mithani14
1Division of Renal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
2Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
3Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
4Department of Melanoma Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
5Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
6Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University Hospitals, Assiut, Egypt
7Institute for Academic Medicine and Weill Cornell Medical College, Houston Methodist Cancer Center, Houston, Texas, USA
8Division of Nephrology, Columbia University Medical Center, New York, New York, USA
9Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
10Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri, USA
11Division of Nephrology, Recanati Millar Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
12Divison of Nephrology, University of Washington, Seattle, Washington, USA
13Nephrology Department, Vall d’Hebron Hospital Universitari, Barcelona, Spain
14Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida, USA

Tài liệu tham khảo

Saran, 2019, US Renal Data System 2018 annual data report: Epidemiology of Kidney Disease in the United States, Am J Kidney Dis, 73, A7, 10.1053/j.ajkd.2019.01.001 Chapman, 2013, Cancer in the transplant recipient, Cold Spring Harb Perspect Med, 3, a015677, 10.1101/cshperspect.a015677 Engels, 2019, Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer, Am J Transplant, 19, 3223, 10.1111/ajt.15495 Sharma, 2015, The future of immune checkpoint therapy, Science, 348, 56, 10.1126/science.aaa8172 Lipson, 2014, Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma, J Clin Oncol, 32, e69, 10.1200/JCO.2013.49.2314 Lipson, 2016, Tumor regression and allograft rejection after administration of anti-PD-1, N Engl J Med, 374, 896, 10.1056/NEJMc1509268 Abdel-Wahab, 2019, Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature, J Immunother Cancer, 7, 106, 10.1186/s40425-019-0585-1 Manohar, 2020, Systematic review of the safety of immune checkpoint inhibitors among kidney transplant patients, Kidney Int Rep, 5, 149, 10.1016/j.ekir.2019.11.015 d’Izarny-Gargas, 2020, Efficacy and tolerance of immune checkpoint inhibitors in transplant patients with cancer: a systematic review, Am J Transplant, 20, 2457, 10.1111/ajt.15811 Barnett, 2017, Preserved renal-allograft function and the PD-1 pathway inhibitor nivolumab, N Engl J Med, 376, 191, 10.1056/NEJMc1614298 Seethapathy, 2019, The incidence, causes, and risk factors of acute kidney injury in patients receiving immune checkpoint inhibitors, Clin J Am Soc Nephrol, 14, 1692, 10.2215/CJN.00990119 Cortazar, 2020, Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study, J Am Soc Nephrol, 31, 435, 10.1681/ASN.2019070676 Fairfax, 2020, Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma, Nat Med, 26, 193, 10.1038/s41591-019-0734-6 Euvrard, 2012, Sirolimus and secondary skin-cancer prevention in kidney transplantation, N Engl J Med, 367, 329, 10.1056/NEJMoa1204166 Dantal, 2018, Sirolimus for secondary prevention of skin cancer in kidney transplant recipients: 5-year results, J Clin Oncol, 36, 2612, 10.1200/JCO.2017.76.6691 Esfahani, 2019, Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation, Nat Commun, 10, 4712, 10.1038/s41467-019-12628-1 Danesh, 2020, Impact of corticosteroids on allograft protection in renal transplant patients receiving anti-PD-1 immunotherapy, Cancer Immunol Immunother, 69, 1937, 10.1007/s00262-020-02644-2 Ito, 2005, Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo, J Immunol, 174, 6648, 10.4049/jimmunol.174.11.6648 Yang, 2008, Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy, Circulation, 117, 660, 10.1161/CIRCULATIONAHA.107.741025 Riella, 2011, Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts, Am J Transplant, 11, 832, 10.1111/j.1600-6143.2011.03451.x Seethapathy, 2020, Incidence and clinical features of immune-related acute kidney injury in patients receiving programmed cell death ligand-1 inhibitors, Kidney Int Rep, 5, 1700, 10.1016/j.ekir.2020.07.011 Arbour, 2018, Impact of baseline steroids on efficacy of programmed cell death-1 and programmed death-ligand 1 blockade in patients with non-small-cell lung cancer, J Clin Oncol, 36, 2872, 10.1200/JCO.2018.79.0006 Ricciuti, 2019, Immune checkpoint inhibitor outcomes for patients with non-small-cell lung cancer receiving baseline corticosteroids for palliative versus nonpalliative indications, J Clin Oncol, 37, 1927, 10.1200/JCO.19.00189 Vermorken, 2008, Platinum-based chemotherapy plus cetuximab in head and neck cancer, New Engl J Med, 359, 1116, 10.1056/NEJMoa0802656 Lanz, 2019, Aggressive squamous cell carcinoma in organ transplant recipients, JAMA Dermatol, 155, 66, 10.1001/jamadermatol.2018.4406 South, 2014, NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis, J Invest Dermatol, 134, 2630, 10.1038/jid.2014.154 Goodman, 2017, Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers, Mol Cancer Ther, 16, 2598, 10.1158/1535-7163.MCT-17-0386 Migden, 2018, PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma, N Engl J Med, 379, 341, 10.1056/NEJMoa1805131 Larkin, 2019, Five-year survival with combined nivolumab and ipilimumab in advanced melanoma, N Engl J Med, 381, 1535, 10.1056/NEJMoa1910836 Vajdic, 2014, Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study, Am J Transplant, 14, 1368, 10.1111/ajt.12716 Robert, 2015, Pembrolizumab versus ipilimumab in advanced melanoma, N Engl J Med, 372, 2521, 10.1056/NEJMoa1503093 Wolchok, 2017, Overall survival with combined nivolumab and ipilimumab in advanced melanoma, N Engl J Med, 377, 1345, 10.1056/NEJMoa1709684 Nankivell, 2010, Rejection of the kidney allograft, N Engl J Med, 363, 1451, 10.1056/NEJMra0902927 Kaplan, 1958, Nonparametric estimation from incomplete observations, J Am Stat Assoc, 53, 457, 10.1080/01621459.1958.10501452