The Th17/Treg balance is disturbed during aging

Acosta-Rodriguez, 2007, Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells, Nat. Immunol., 8, 646

Aggarwal, 2003, Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17, J. Biol. Chem., 278, 1914

Andre, 2009, Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications, Am. J. Pathol., 174, 1587

Annunziato, 2007, Phenotypic and functional features of human Th17 cells, J. Exp. Med., 204, 1861

Bao, 2010, Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent, Am. J. Clin. Nutr., 91, 1641

Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector T (H)17 and regulatory T cells, Nature, 441, 238

Burgler, 2010, RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter, J. Immunol., 184, 6169

Cakman, 1996, Dysregulation between TH1 and TH2 T cell subpopulations in the elderly, Mech. Ageing Dev., 87, 197, 10.1016/0047-6374(96)01708-3

De Martinis, 2004, Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons, Immunol. Cell Biol., 82, 415, 10.1111/j.0818-9641.2004.01242.x

Fontenot, 2003, Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells, Nat. Immunol., 4, 330, 10.1038/ni904

Franceschi, 2000, Inflammaging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 254

Fukada, 2011, Zinc homeostasis and signaling in health and diseases: zinc signaling, J. Biol. Inorg. Chem., 16, 1134

Fulop, 2009, Signal transduction changes in T-cells with aging, 675

Gardner, 2009, Age-related changes in Type 1 and Type 2. Cytokine production in humans, 753

Gardner, 2006, Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly, population, Vaccine, 24, 1609, 10.1016/j.vaccine.2005.09.058

Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat. Immunol., 6, 1132

Hori, 2003, Science, 299, 1057, 10.1126/science.1079490

Hwang, 2009, Aging and human CD4(+) regulatory T cells, Mech. Ageing. Dev., 130, 517

Kahmann, 2008, Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions, Rejuvenation Res., 11, 237

Karanfilov, 1999, Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets, Mech. Ageing. Dev., 109, 112

Khader, 2007, IL-23 and IL-17 in the establishment of protective pulmonary CD4(+) T cell responses after vaccination and during Mycobacterium tuberculosis challenge, Nat. Immunol., 8, 377

Krabbe, 2004, Inflammatory mediators in the elderly, Exp. Gerontol., 39, 699

Lee, 2011, Age-associated alteration in naive and memory Th17 cell response in humans, Clin. Immunol., 140, 91

Lenarczyk, 2000, Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls, Clin. Exp. Immunol., 122, 48

Ligthart, 1984, Admission criteria for immunogerontological studies — the SENIEUR protocol, Mech. Ageing. Dev., 28, 55

Linton, 2004, Age-related changes in lymphocyte development and function, Nat. Immunol., 5, 139

Mahbub, 2011, Aging of the innate immune system: an update, Curr. Immunol. Rev., 7, 115

Moss, 2009, The role of T-regulatory cells in immune senescence, 193

Murasko, 1987, Decline in mitogen induced proliferation of lymphocytes with increasing age, Clin. Exp. Immunol., 70, 448

Nistala, 2009, Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis, Rheumatology (Oxford), 48, 602, 10.1093/rheumatology/kep028

Ouyang, 2008, The biological functions of T helper 17 cell effector cytokines in inflammation, Immunity, 28, 467

Ouyang, 2009, Novel therapeutic targets along the Th17 pathway, Eur. J. Immunol., 39, 675

Ouyang, 2011, Potentiation of Th17 cytokines in aging process contributes to the development of colitis, Cell. Immunol., 266, 217

Pawelec, 1999, T cell immunosenescence in vitro and in vivo, Exp. Gerontol., 34, 429

Prasad, 1993, Zinc deficiency in elderly patients, Nutrition, 9, 224

Prasad, 2004, Antioxidant effect of zinc in humans, Free Radic. Biol. Med., 37, 1190

Prasad, 2007, Zinc supplementation, decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress, Am. J. Clin. Nutr., 85, 844

Rink, 1998, Altered cytokine production in the elderly, Mech. Ageing. Dev., 102, 209

Saurwein-Teissl, 2000, An imbalance between pro- and anti-inflammatory cytokines, a characteristic feature of old age, Cytokine, 12, 1161

Schröder, 2005, Differential synthesis of two Interleukin-1 receptor antagonist variants and Interleukin-8 by peripheral blood neutrophils, Cytokine, 32, 246, 10.1016/j.cyto.2005.10.004

Stacy, 2002, Split tolerance in a novel transgenic model of autoimmune myrasthenia gravis, J. Immunol., 169, 6579

Stockinger, 2007, Differentiation and function of Th17 T cells, Curr. Opin. Immunol., 19, 286

Streeck, 2008, Rapid ex vivo isolation and long-term culture of human Th17 cells, J. Immunol. Methods, 333, 125

Tang, 2012, Interleukin-23: as a drug target for autoimmune inflammatory diseases, Immunology, 135, 124

Vukmanovic-Stejic, 2006, Human CD4(+)CD25(hi)Foxp3(+) regulatory T cells are derived by rapid turnover of memory populations in vivo, J. Clin. Invest., 116, 2433

Wessels, 2010, Immunosenescence of polymorphonuclear neutrophils, Sci. World J., 10, 160

Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells, 8, 950

Ye, 2001, An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice, Neuroimmunomodulation, 9, 192

Ziegler, 2009, FOXP3 and the regulation of Treg/Th17 differentiation, Microbes Infect., 11, 598

Zhou, 2008, TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function, Nature, 453, 236, 10.1038/nature06878

Zúñiga, 2013, Th17 cell development: from the cradle to the grave, Immunol. Rev., 252, 88