[Translated article] Pilot study to determine the association between gut microbiota and fragility hip fracture

A. Roselló-Añón1, C. Chiappe1, M.R. Valverde-Vázquez1, M.J. Sangüesa-Nebot1, M.C. Gómez-Cabrera2, G. Pérez-Martínez3, J. Doménech-Fernández1,4
1Servicio de Cirugía Ortopédica y Traumatología, Hospital Arnau de Vilanova, Valencia, Spain
2Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain
3Laboratory of Lactic acid Bacteria and Probiotics, Department of Food Biotechnology, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (CSIC), Valencia, Spain
4Universidad Católica de Valencia, Valencia, Spain

Tài liệu tham khảo

Svedbom, 2013, Osteoporosis in the European Union: a compendium of country-specific reports, Arch Osteoporos, 8, 137, 10.1007/s11657-013-0137-0 Kanis, 2004, A meta-analysis of previous fracture and subsequent fracture risk, Bone, 35, 375, 10.1016/j.bone.2004.03.024 Schuit, 2004, Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam study, Bone, 34, 195, 10.1016/j.bone.2003.10.001 Lozupone, 2012, Diversity, stability and resilience of the human gut microbiota, Nature, 489, 220, 10.1038/nature11550 Jones, 2018, Osteomicrobiology: the influence of gut microbiota on bone in health and disease, Bone, 115, 59, 10.1016/j.bone.2017.04.009 Li, 2021, The role of gut microbiota in bone homeostasis, Bone Joint Res, 10.1302/2046-3758.101.BJR-2020-0273.R1 Sjögren, 2012, The gut microbiota regulates bone mass in mice, J Bone Miner Res, 27, 1357, 10.1002/jbmr.1588 OpenEpi: Open Source Epidemiologic Statistics for Public Health, Versión. Available from: www.OpenEpi.com [accessed 8.4.19]. Charlson, 1987, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, 40, 10.1016/0021-9681(87)90171-8 Mahoney, 1965, Functional evaluation: the Barthel index, Md State Med J, 14 Reisberg, 1982, The global deterioration scale for assessment of primary degenerative dementia, Am J Psychiatry, 139 Coque González, 2016 Bäuerl, 2014, Changes in cecal microbiota and mucosal gene expression revealed new aspects of epizootic rabbit enteropathy, PLoS ONE, 9, 10.1371/journal.pone.0105707 Chong, 2020, Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data, Nat Protoc, 15, 10.1038/s41596-019-0264-1 Quast, 2013, The SILVA ribosomal RNA gene database project: improved data processing and web-based tools, Nucleic Acids Res, 41, 10.1093/nar/gks1219 Flores, 2012, A direct PCR approach to accelerate analyses of human-associated microbial communities, PLoS ONE, 7, 10.1371/journal.pone.0044563 Kim, 2017, Deciphering diversity indices for a better understanding of microbial communities, J Microbiol Biotechnol, 27, 10.4014/jmb.1709.09027 Charles, 2014, The intestinal microbiome and skeletal fitness: connecting bugs and bones, Clin Immunol, 159, 163, 10.1016/j.clim.2015.03.019 Schwarzer, 2016, Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition, Science (1979), 351, 854 Huttenhower, 2012, Structure, function and diversity of the healthy human microbiome, Nature, 486 Morgan, 2012, Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment, Genome Biol, 13, 10.1186/gb-2012-13-9-r79 Stojanov, 2020, The influence of probiotics on the firmicutes/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease, Microorganisms, 10.3390/microorganisms8111715 Tomkinson, 1998, The role of estrogen in the control of rat osteocyte apoptosis, J Bone Miner Res, 13, 10.1359/jbmr.1998.13.8.1243 Guigoz, 2008, The inflammatory status of old age can be nurtured from the intestinal environment, Curr Opin Clin Nutr Metab Care, 10.1097/MCO.0b013e3282f2bfdf Louis, 2017, Formation of propionate and butyrate by the human colonic microbiota, Environ Microbiol, 10.1111/1462-2920.13589 Tyagi, 2018, The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression, Immunity, 49, 10.1016/j.immuni.2018.10.013 Smith, 2013, The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis, Science (1979), 341, 569 Wang, 2017, Diversity analysis of gut microbiota in osteoporosis and osteopenia patients, PeerJ, 2017 Salazar, 2019, Age-associated changes in gut microbiota and dietary components related with the immune system in adulthood and old age: a cross-sectional study, Nutrients, 11, 10.3390/nu11081765 Foster, 2017, Metacoder: an R package for visualization and manipulation of community taxonomic diversity data, PLoS Comput Biol, 13, 10.1371/journal.pcbi.1005404