The human fatty acid synthase: A new therapeutic target for coxsackievirus B3-induced diseases?

Barnard, 2006, Current status of anti-picornavirus therapies, Curr. Pharm. Des., 12, 1379, 10.2174/138161206776361129 Barton, 1993, Coupled translation and replication of poliovirus RNA in vitro: synthesis of functional 3D polymerase and infectious virus, J. Virol., 67, 822, 10.1128/JVI.67.2.822-831.1993 Barton, 1997, Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C, J. Virol., 71, 8482, 10.1128/JVI.71.11.8482-8489.1997 Barton, 1995, Complete replication of poliovirus in vitro: preinitiation RNA replication complexes require soluble cellular factors for the synthesis of VPg-linked RNA, J. Virol., 69, 5516, 10.1128/JVI.69.9.5516-5527.1995 Beausoleil, 2004, Large-scale characterization of HeLa cell nuclear phosphoproteins, Proc. Natl. Acad. Sci. U.S.A., 101, 12130, 10.1073/pnas.0404720101 Bowles, 1986, Detection of coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy, Lancet, 1, 1120, 10.1016/S0140-6736(86)91837-4 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Bu, 1989, Inhibition of bacterially expressed HIV protease activity determined by an in vitro cleavage assay with MuLV Pr65gag, AIDS Res. Hum. Retroviruses, 5, 259, 10.1089/aid.1989.5.259 Doherty, 1998, Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis, Electrophoresis, 19, 355, 10.1002/elps.1150190234 Egger, 2002, Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex, J. Virol., 76, 5974, 10.1128/JVI.76.12.5974-5984.2002 Fogg, 2003, Membrane requirements for uridylylation of the poliovirus VPg protein and viral RNA synthesis in vitro, J. Virol., 77, 11408, 10.1128/JVI.77.21.11408-11416.2003 Frisk, 1984, Reverse radioimmunoassays of IgM and IgG antibodies to coxsackie B viruses in patients with acute myopericarditis, J. Med. Virol., 14, 191, 10.1002/jmv.1890140302 Funabashi, 1989, Binding site of cerulenin in fatty acid synthetase, J. Biochem. (Tokyo), 105, 751, 10.1093/oxfordjournals.jbchem.a122739 Gebhard, 1998, Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance, Am. J. Pathol., 153, 417, 10.1016/S0002-9440(10)65585-X Gillum, 1986, Idiopathic cardiomyopathy in the United States 1970–1982, Am. Heart J., 111, 752, 10.1016/0002-8703(86)90111-0 Görg, 1997, Very alkaline immobilized pH gradients for two-dimensional electrophoresis of ribosomal and nuclear proteins, Electrophoresis, 18, 328, 10.1002/elps.1150180306 Guinea, 1990, Phospholipid biosynthesis and poliovirus genome replication, two coupled phenomena, EMBO J., 9, 2011, 10.1002/j.1460-2075.1990.tb08329.x Halvorson, 1984, Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid, Lipids, 19, 851, 10.1007/BF02534514 Heiligtag, 2002, Key role of mitochondria in cerulenin-mediated apoptosis, Cell Death Differ., 9, 1017, 10.1038/sj.cdd.4401055 Henke, 1995, The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis, J. Virol., 69, 6720, 10.1128/JVI.69.11.6720-6728.1995 Henke, 2000, Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva, J. Virol., 74, 4284, 10.1128/JVI.74.9.4284-4290.2000 Henke, 2001, The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva, Virology, 289, 15, 10.1006/viro.2001.1082 Huber, 1996, Modulation of cytokine expression by CD4+ T cells during coxsackievirus B3 infections of BALB/c mice initiated by cells expressing the gamma delta + T-cell receptor, J. Virol., 70, 3039, 10.1128/JVI.70.5.3039-3044.1996 Huber, 1999, gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis, J. Virol., 73, 5630, 10.1128/JVI.73.7.5630-5636.1999 Knowlton, 1996, A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3, J. Virol., 70, 7811, 10.1128/JVI.70.11.7811-7818.1996 Kuhajda, 1994, Fatty acid synthesis: a potential selective target for antineoplastic therapy, Proc. Natl. Acad. Sci. U.S.A., 91, 6379, 10.1073/pnas.91.14.6379 Kuhajda, 2000, Synthesis and antitumor activity of an inhibitor of fatty acid synthase, Proc. Natl. Acad. Sci. U.S.A., 97, 3450, 10.1073/pnas.050582897 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Leipner, 1999, Coxsackievirus B3-induced myocarditis in MHC class II-deficient mice, J. Hum. Virol., 2, 102 Li, 2004, Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression, J. Virol., 78, 4197, 10.1128/JVI.78.8.4197-4206.2004 Liu, 2000, The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease, Nat. Med., 6, 429, 10.1038/74689 Martin, 2004, Characterization of coxsackievirus B3-caused apoptosis under in vitro conditions, Med. Microbiol. Immunol., 193, 133, 10.1007/s00430-003-0197-7 Mena, 1999, The role of B lymphocytes in coxsackievirus B3 infection, Am. J. Pathol., 155, 1205, 10.1016/S0002-9440(10)65223-6 Moche, 1999, Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase, J. Biol. Chem., 274, 6031, 10.1074/jbc.274.10.6031 Molla, 1993, Effects of temperature and lipophilic agents on poliovirus formation and RNA synthesis in a cell-free system, J. Virol., 67, 5932, 10.1128/JVI.67.10.5932-5938.1993 Olivetti, 1997, Apoptosis in the failing human heart, N. Engl. J. Med., 336, 1131, 10.1056/NEJM199704173361603 Opavsky, 2002, Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis, J. Clin. Invest., 109, 1561, 10.1172/JCI0213971 Pal, 1988, Processing of the structural proteins of human immunodeficiency virus type 1 in the presence of monensin and cerulenin, Proc. Natl. Acad. Sci. U.S.A., 85, 9283, 10.1073/pnas.85.23.9283 Paul, 2003, Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirus, J. Virol., 77, 891, 10.1128/JVI.77.2.891-904.2003 Pereira, 1998, Inhibition of Mayaro virus replication by cerulenin in Aedes albopictus cells, Acta Virol., 42, 383 Pizer, 2000, Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts, Cancer Res., 60, 213 Prasad, 1997, CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein, Proc. Natl. Acad. Sci. U.S.A., 94, 6346, 10.1073/pnas.94.12.6346 Rabilloud, 1994, Sample application by in-gel rehydration improves the resolution of two-dimensional electrophoresis with immobilized pH gradients in the first dimension, Electrophoresis, 15, 1552, 10.1002/elps.11501501223 Rassmann, 2006, Proteome alterations in human host cells infected with coxsackievirus B3, J. Gen. Virol., 87, 2631, 10.1099/vir.0.81819-0 Reed, 1938, A simple method of estimating fifty per cent endpoints, Am. J. Hyg., 27, 493 Rendina, 2005, Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates, Biochem. J., 388, 895, 10.1042/BJ20041963 Reyes, 1985, Coxsackievirus myocarditis—with special reference to acute and chronic effects, Prog. Cardiovasc. Dis., 27, 373, 10.1016/0033-0620(85)90001-5 Sambrook, 1989 Sanchez, 1997, Improved and simplified in-gel sample application using reswelling of dry immobilized pH gradients, Electrophoresis, 18, 324, 10.1002/elps.1150180305 Shimizu, 2000, Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives, J. Virol., 74, 4146, 10.1128/JVI.74.9.4146-4154.2000 Si, 2005, Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release, J. Virol., 79, 13875, 10.1128/JVI.79.22.13875-13881.2005 Sugrue, 1992, The clinical course of idiopathic dilated cardiomyopathy. A population-based study, Ann. Intern. Med., 117, 117, 10.7326/0003-4819-117-2-117 Tomoda, 1984, Cerulenin resistance in a cerulenin-producing fungus. II. Characterization of fatty acid synthetase from Cephalosporium caerulens, J. Biochem. (Tokyo), 95, 1705, 10.1093/oxfordjournals.jbchem.a134784 Verstrepen, 2001, Rapid detection of enterovirus RNA in cerebrospinal fluid specimens with a novel single-tube real-time reverse transcription-PCR assay, J. Clin. Microbiol., 39, 4093, 10.1128/JCM.39.11.4093-4096.2001 Wakil, 1989, Fatty acid synthase, a proficient multifunctional enzyme, Biochemistry, 28, 4523, 10.1021/bi00437a001 Wessely, 1998, Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes, Circulation, 98, 450, 10.1161/01.CIR.98.5.450 Wessely, 1998, Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation–contraction coupling and dilated cardiomyopathy, J. Clin. Invest., 102, 1444, 10.1172/JCI1972 Woodruff, 1980, Viral myocarditis. A review, Am. J. Pathol., 101, 425