Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers

Chronic Diseases and Translational Medicine - Tập 5 - Trang 97-104 - 2019
Ai-Min Yang1,2, Xiao-Bin Hu1, Simin Liu2, Ning Cheng3, De-Sheng Zhang4, Juan-Sheng Li1, Hai-Yan Li4, Xiao-Wei Ren1, Na Li4, Xi-Pin Sheng1, Jiao Ding4, Shan Zheng1, Min-Zheng Wang1, Tong-Zhang Zheng2, Ya-Na Bai1
1Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China
2Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02912, USA
3Center of Medical Laboratory, Lanzhou University, Lanzhou, Gansu 730000, China
4Workers' Hospital of Jinchuan Group Co., Ltd., Jinchang, Gansu 737100, China

Tóm tắt

AbstractObjective

Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers.

Methods

We conducted a cross‐sectional analysis of 26,008 Chinese male workers in an occupational cohort study from 2011 to 2013. We assessed metal exposure and alcohol consumption at baseline in these workers who were aged ≥20 years. Based on occupations which were categorized according to measured urine metal levels, multiple logistic regression analyses were used to evaluate the independent and joint effects of metal and alcohol exposure on the risk of T2D and prediabetes.

Results

Risks of T2D (Ptrend = 0.001) and prediabetes (Ptrend = 0.001) were significantly elevated with increasing number of standard drinks per week, years of drinking, and lifetime alcohol consumption. An adjusted odds ratio (OR) of 6.1 (95% confidence interval [CI]: 4.8–7.8) was observed for the smelting/refining workers (highest metal exposure levels) who had the highest lifetime alcohol consumption (>873 kg) (Pinteraction = 0.018), whereas no statistically significant joint effect was found for prediabetes (Pinteraction = 0.515).

Conclusions

Both exposures to metal and heavy alcohol intake were associated with the risk of diabetes in this large cohort of male workers. There was a strong interaction between these two exposures in affecting diabetes risk that needs to be confirmed in future studies.


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Thông tin xuất bản

Chronic Diseases and Translational Medicine

Tập 5

97-104

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