Fatty acid metabolism: target for metabolic syndrome

Journal of Lipid Research - Tập 50 - Trang S138-S143 - 2009
Salih J. Wakil1, Lutfi A. Abu-Elheiga1
1Verna and Marrs McLean Department of Biochemistry and Molecular Biology; Baylor College of Medicine, Houston, TX, 77030

Tài liệu tham khảo

Wakil, 1989, The fatty acid synthase: a proficient multifunctional enzyme, Biochemistry., 28, 4523, 10.1021/bi00437a001 McGarry, 1977, A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis, J. Clin. Invest., 60, 265, 10.1172/JCI108764 Wakil, 1958, Evidence for the participation of biotin in the enzymic synthesis of fatty acids, Biochim. Biophys. Acta., 29, 225, 10.1016/0006-3002(58)90177-X Abu-Elheiga, 1997, Human acetyl-CoA carboxylase 2: molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms, J. Biol. Chem., 272, 10669, 10.1074/jbc.272.16.10669 Abu-Elheiga, 1995, Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms, Proc. Natl. Acad. Sci. USA., 92, 4011, 10.1073/pnas.92.9.4011 Abu-Elheiga, 2000, The subcellular localization of acetyl-CoA carboxylase 2, Proc. Natl. Acad. Sci. USA., 97, 1444, 10.1073/pnas.97.4.1444 Abu-Elheiga, 2005, Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal, Proc. Natl. Acad. Sci. USA., 102, 12011, 10.1073/pnas.0505714102 Kim, 1997, Regulation of mammalian acetyl coenzyme A carboxylase, Annu. Rev. Nutr., 17, 77, 10.1146/annurev.nutr.17.1.77 Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell., 89, 331, 10.1016/S0092-8674(00)80213-5 Pegorier, 2004, Control of gene expression by fatty acids, J. Nutr., 134, 2444S, 10.1093/jn/134.9.2444S Davies, 2008, Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity, J. Biol. Chem., 283, 24029, 10.1074/jbc.M801539200 Dentin, 2006, Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice, Diabetes., 55, 2159, 10.2337/db06-0200 Iizuka, 2004, Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis, Proc. Natl. Acad. Sci. USA., 101, 7281, 10.1073/pnas.0401516101 Mao, 2003, Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5′-untranslated mRNA region, Proc. Natl. Acad. Sci. USA., 100, 7517, 10.1073/pnas.1332670100 Kim, 2003, Acetyl-CoA carboxylase beta expression mediated by MyoD and muscle regulatory factor 4 is differentially affected by retinoic acid receptor and retinoid X receptor, Exp. Mol. Med., 35, 23, 10.1038/emm.2003.4 Hardie, 2002, Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase, Biochem. Soc. Trans., 30, 1064, 10.1042/bst0301064 Hardie, 2008, AMPK: a key regulator of energy balance in the single cell and the whole organism, Int. J. Obes. (Lond.)., 4, S7, 10.1038/ijo.2008.116 Mabrouk, 1990, Acute hormonal control of acetyl-CoA carboxylase: the roles of insulin, glucagon, and epinephrine, J. Biol. Chem., 265, 6330, 10.1016/S0021-9258(19)39330-5 Janovská, 2008, AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity, Mol. Cell. Endocrinol., 284, 1, 10.1016/j.mce.2007.12.013 Chirala, 2003, Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero, Proc. Natl. Acad. Sci. USA., 100, 6558, 10.1073/pnas.0931394100 Beigneux, 2004, ATP-citrate lyase deficiency in the mouse, J. Biol. Chem., 279, 9557, 10.1074/jbc.M310512200 Petersen, 2006, Etiology of insulin resistance, Am. J. Med., 119, S10, 10.1016/j.amjmed.2006.01.009 Mao, 2006, Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis, Proc. Natl. Acad. Sci. USA., 103, 8552, 10.1073/pnas.0603115103 Savage, 2006, Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2, J. Clin. Invest., 116, 817, 10.1172/JCI27300 An, 2004, Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance, Nat. Med., 10, 268, 10.1038/nm995 Chakravarthy, 2005, New hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis, Cell Metab., 1, 309, 10.1016/j.cmet.2005.04.002 Abu-Elheiga, 2001, Continuous fatty acid oxidation in mice lacking acetyl-CoA carboxylase 2, Science., 291, 2613, 10.1126/science.1056843 Abu-Elheiga, 2003, ACC2 mutant mice are protected against obesity and diabetes induced by high fat high carbohydrate diets, Proc. Natl. Acad. Sci. USA., 100, 10207, 10.1073/pnas.1733877100 Oh, 2005, Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice, Proc. Natl. Acad. Sci. USA., 102, 1384, 10.1073/pnas.0409451102 Choi, 2007, Continuous fat oxidation in Acetyl-CoA carboxylase 2 mutant mice increases total energy expenditure, reduces fat mass and improves insulin sensitivity, Proc. Natl. Acad. Sci. USA., 104, 16480, 10.1073/pnas.0706794104 Ruderman, 2004, AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome, Nat. Rev. Drug Discov., 3, 340, 10.1038/nrd1344 Koistinen, 2003, 5-Amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes, Diabetes., 52, 1066, 10.2337/diabetes.52.5.1066 Randle, 1965, The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus, Ann. N. Y. Acad. Sci., 1, 324, 10.1111/j.1749-6632.1965.tb34800.x Essop, 2008, Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice, Am. J. Physiol. Heart Circ. Physiol., 295, H256, 10.1152/ajpheart.91489.2007 Tong, 2006, Acetyl-coenzyme A carboxylases: versatile targets for drug discovery, J. Cell. Biochem., 99, 1476, 10.1002/jcb.21077